Sodium Cation

Mechanism-of-action class: Osmotic Activity.

• Elliotts B Solution is indicated as a diluent for the intrathecal administration of methotrexate sodium and cytarabine for the prevention or treatment of meningeal leukemia or lymphocytic lymphoma.ICD-10: C85.90, C95.90

• None known.contraindicated

See product labeling for methotrexate sodium and cytarabine. Elliotts B Solution is intended for intrathecal administration only. Elliotts B Solution does not contain antibacterial preservatives and introduction of contaminated solutions into the cerebrospinal fluid may have extremely serious consequences. Therefore, administration of intrathecal solutions should be accomplished as soon as possible after preparation. A sterile filter-needle should be used to withdraw the contents of the ampule. Intrathecal drug products should be inspected visually for particulate matter and discoloration prior to administration. Preparation and Administration Precautions Elliotts B Solution is a diluent for the cytotoxic anticancer agents, methotrexate sodium and cytarabine. Care should be exercised in the handling and preparation of infusion solutions with these products. (See product labeling for methotrexate sodium and cytarabine.)

Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by personnel skilled in the technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. The labeling for methotrexate sodium and cytarabine should be consulted.

Adverse reactions may occur with any given intrathecal injection due to the chemotherapy or the technique of intrathecal administration. (See product labeling for methotrexate sodium and cytarabine.) Preservative-free methotrexate sodium and cytarabine should be used to minimize adverse reactions due to preservatives. If an adverse reaction does occur, discontinue the administration, evaluate the patient, institute appropriate therapeutic countermeasures and, if possible, save the remainder of the unused solution(s) for examination.

Usage in Pregnancy All components of Elliotts B Solution are normal body constituents. Animal reproduction studies have not been conducted with Elliotts B Solution.

Elliotts B Solution is a diluent. In the event of a drug, fluid or solute overload following administration, evaluate the patient's condition, and institute appropriate corrective treatment. (See product labeling for methotrexate sodium and cytarabine.)

• Sep 27, 1996NDANDA020577Lukare Medical Llc

Recent PubMed references pinned to Sodium Cation as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Proton signaling links epithelial sensing to neural control of host defense in C. elegans.
  Nature communications · 2026 · Lei Y, Zhan X, Chen C, et al.
  PMID 41888139DOI 10.1038/s41467-026-71088-6
• A valve-switching based ion chromatography strategy for simultaneous determination of trace cations in table salt.
  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment · 2026 · Ni C, Zhang H, Hao W, et al.
  PMID 41869859DOI 10.1080/19440049.2026.2647901
• Structure and mechanism of cellular cation-transporters: Affinity-binding and murburn models.
  International journal of biological macromolecules · 2026 · Manoj KM, Jaeken L, Gideon DA, et al.
  PMID 41672163DOI 10.1016/j.ijbiomac.2026.150614
• Allosteric effects of the coupling cation in melibiose transporter MelB.
  eLife · 2026 · Hariharan P, Shi Y, Bakhtiiari A, et al.
  PMID 41604452DOI 10.7554/eLife.108335
• Automated methods for multi-isotopic analysis of major cations in biological samples: application to chronic kidney disease of unknown etiology.
  Analytical and bioanalytical chemistry · 2026 · Grigoryan R, Swenson W, Field MP, et al.
  PMID 41533064DOI 10.1007/s00216-025-06309-w
• A proton-gated channel identified in the centipede antenna.
  EMBO reports · 2025 · Dong W, Yuan L, Shang J, et al.
  PMID 41116071DOI 10.1038/s44319-025-00606-2
• A Double-Layer (1)H/(23)Na Transceiver Array for Human Brain MRI at 7T.
  NMR in biomedicine · 2025 · Lou F, Duan C, Quan Z, et al.
  PMID 41098051DOI 10.1002/nbm.70162
• Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on Shewanella oneidensis by Compromising Membrane Protein Functionality.
  ACS nano · 2025 · Zhang S, Jia B, Huang W, et al.
  PMID 40999680DOI 10.1021/acsnano.5c04610

The 7 most recently updated of 7 ClinicalTrials.gov registrations naming Sodium Cation as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Comparison of Potassium Binders in the ER
  Terminated · Phase 4 · Interventional · 37 enrolled · University of California, Irvine
  NCT04585542updated 2026-04-22
• Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP).
  Completed · Interventional · 30 enrolled · Benha University
  NCT07497009updated 2026-03-31
• Potassium Binder in CKD Patients (With Hyperkalemia) (DiPo Trial)
  Unknown · Phase 1 · Interventional · 20 enrolled · Brigham and Women's Hospital
  NCT04727840updated 2021-02-01
• Coronary Arteriogenetic Heparinized Exercise
  Completed · Interventional · 32 enrolled · Clinical Centre of Serbia
  NCT03350737updated 2020-05-13
• A Pilot Study to Substantiate the Use of the Jay Sensitivity Sensor Probe
  Completed · Interventional · 137 enrolled · Unilever R&D
  NCT02789618updated 2018-06-08
• Softened Water for Eczema Prevention Pilot Trial
  Unknown · Interventional · 80 enrolled · King's College London
  NCT03270566updated 2018-02-19
• Safety and Efficacy of Intravenous Magnesium Sulfate in Modulating Changes in Symptoms and Divalent Cation Levels Associated With Foscavir Therapy: A Phase IV Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Pilot Study
  Completed · Phase 4 · Interventional · 12 enrolled · Astra USA
  NCT00002146updated 2005-06-24

Frequently asked questions

How does Sodium Cation work?

Mechanism-of-action class: Osmotic Activity.

What is Sodium Cation used for?

According to FDA labeling, Sodium Cation carries indications including: Elliotts B Solution is indicated as a diluent for the intrathecal administration of methotrexate sodium and cytarabine for the prevention or treatment of meningeal leukemia or lymphocytic lymphoma.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Sodium Cation?

Sodium Cation is classified as Osmotic Laxative, Osmotic Activity, Increased Large Intestinal Motility, Inhibition Large Intestine Fluid/Electrolyte Absorption.

What are the contraindications for Sodium Cation?

Sodium Cation labeling lists contraindications including: None known.. Always consult the full prescribing information and a clinician.