Sodium Citrate

Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity.

• Uses For the relief of heartburn, sour stomach, acid indigestion, and upset stomach and accompanying nausea associated with overindulgence in food and drink.ICD-10: R11.2

Directions Adults: 2-4 tablets. Children: Consult a doctor for appropriate dosage. Chew tablets completely. Dosage may be repeated after 15 minutes, not to exceed 16 tablets in a 24-hour period unless advised by a doctor. Read all package directions and warnings before use and use only as directed. Nauzene Chewables are intended for use by normally healthy persons only. Persons under 18 years of age should use only as directed by a doctor.

Warnings

• Feb 3, 2010ANDAANDA091387B Braun

1. 1Vomiting26419%
2. 2Off Label Use26019%
3. 3Nausea25819%
4. 4Hyponatraemia23917%
5. 5General Physical Health Deterioration23017%
6. 6Sepsis23017%
7. 7Abdominal Pain22816%
8. 8Abdominal Distension22616%
9. 9Constipation21816%
10. 10Ascites21716%
11. 11Multiple Organ Dysfunction Syndrome21716%
12. 12Appendicitis21616%
13. 13Stress21415%
14. 14Appendicolith21315%
15. 15Cardiogenic Shock21215%

Recent PubMed references pinned to Sodium Citrate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Pediatric autologous peripheral blood stem cell collection without heparin using a highly concentrated sodium citrate anticoagulant: A retrospective comparison with standard ACD-A.
  Transfusion · 2026 · Fujii K, Kitamura W, Washio K, et al.
  PMID 41630350DOI 10.1111/trf.70102
• Novel leukocytapheresis method using highly concentrated sodium citrate solution for the manufacturing of tisagenlecleucel.
  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2025 · Kitamura W, Fujii K, Abe M, et al.
  PMID 41109063DOI 10.1016/j.transci.2025.104265
• Mechanistic insights into sodium citrate-induced metabolic rewiring for enhanced S-adenosylmethionine synthesis via transcriptomics and constraint-based modeling.
  Bioprocess and biosystems engineering · 2026 · Dong L, Song W, Li Z, et al.
  PMID 41081932DOI 10.1007/s00449-025-03242-1
• Efficacy and safety of naphlimostat mesylate versus sodium citrate in CRRT for EICU patients with coagulation dysfunction: A STROBE-compliant observational study.
  Medicine · 2025 · Song B, Liu C, Fu K, et al.
  PMID 41054083DOI 10.1097/MD.0000000000044932
• Individual and Combined Effects of Sodium Bicarbonate and Sodium Citrate Supplementation on High-Intensity Exercise Performance in Highly Trained Female CrossFit Athletes.
  International journal of sports physiology and performance · 2025 · Martin RAXJ, Yang X, McNaughton LR, et al.
  PMID 40840560DOI 10.1123/ijspp.2024-0190
• Fish Collagen-Based Bilayer Composite Scaffold Functionalized With Fibrin/Hydroxyapatite/Sodium Citrate for Osteochondral Tissue Engineering-In Vitro and In Vivo Studies.
  Journal of biomedical materials research. Part A · 2025 · Vijayalekha A, Anandasadagopan SK, Gopal T, et al.
  PMID 40808612DOI 10.1002/jbm.a.37977
• Novel method for autologous peripheral blood stem cell harvest using highly concentrated sodium citrate solution replacing acid citrate dextrose solution A.
  Transfusion · 2025 · Kitamura W, Fujii K, Abe M, et al.
  PMID 40708443DOI 10.1111/trf.18360
• Effect of sodium citrate anticoagulant solution in continuous veno-venous hemofiltration in critically ill children.
  BMC pediatrics · 2025 · Ye X, Zhang S, Tang M, et al.
  PMID 40598149DOI 10.1186/s12887-025-05762-x

The 10 most recently updated of 2,123 ClinicalTrials.gov registrations naming Sodium Citrate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung
  Recruiting · Phase 2 · Phase 3 · Interventional · 189 enrolled · National Cancer Institute (NCI)
  NCT05058651updated 2026-06-12
• A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma
  Recruiting · Phase 2 · Phase 3 · Interventional · 1,122 enrolled · National Cancer Institute (NCI)
  NCT05691478updated 2026-06-12
• A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
  Recruiting · Phase 2 · Interventional · 50 enrolled · National Cancer Institute (NCI)
  NCT06064097updated 2026-06-12
• Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
  Recruiting · Phase 3 · Interventional · 1,210 enrolled · National Cancer Institute (NCI)
  NCT04267848updated 2026-06-12
• Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma
  Recruiting · Phase 2 · Interventional · 108 enrolled · National Cancer Institute (NCI)
  NCT07281417updated 2026-06-12
• Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer
  Recruiting · Phase 2 · Phase 3 · Interventional · 613 enrolled · National Cancer Institute (NCI)
  NCT01810913updated 2026-06-12
• Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
  Recruiting · Phase 3 · Interventional · 478 enrolled · National Cancer Institute (NCI)
  NCT06172296updated 2026-06-12
• Impact of Treatment With Rituximab on the Progression of Humoral Acute Rejection After Renal Transplantation
  Completed · Phase 3 · Interventional · 40 enrolled · University Hospital, Tours
  NCT01350882updated 2026-06-12
• Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
  Active not recruiting · Phase 3 · Interventional · 10,273 enrolled · National Cancer Institute (NCI)
  NCT00310180updated 2026-06-11
• Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer
  Recruiting · Phase 2 · Phase 3 · Interventional · 131 enrolled · National Cancer Institute (NCI)
  NCT04628767updated 2026-06-11

Frequently asked questions

How does Sodium Citrate work?

Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity.

What is Sodium Citrate used for?

According to FDA labeling, Sodium Citrate carries indications including: Uses For the relief of heartburn, sour stomach, acid indigestion, and upset stomach and accompanying nausea associated with overindulgence in food and drink.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Sodium Citrate?

Sodium Citrate is classified as Salt solutions, Acid-Base Activity, Electrolyte Activity, Increased Intravascular Volume, Increased Renal HCO3- Excretion, Unknown Physiological Effect.

What are the brand names for Sodium Citrate?

Sodium Citrate is marketed under brand names including BSS Ophthalmic Solution, Cytra 2, Cytra-3, Emetrol Chewables, Emetrol Powder, Oracit, Regiocit.