Sodium Fluoride

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

• Use aids in the prevention of dental cavities

Directions Adults and children 6 years of age and older: use once a day after brushing your teeth with a toothpaste vigorously swish 10 milliliters of rinse between your teeth for 1 minute and then spit out do not swallow the rinse do not eat or drink for 30 minutes after rinsing instruct children under 12 years of age in good rinsing habits (to minimize swallowing) supervise children as necessary until capable of using without supervision Children under 6 years of age: consult a dentist or doctor

for this product

Distributed By Meijer Distribution, Inc. Grand Rapids, MI 49544 www.meijer.com Our Quality Guarantee www.meijer.com/satisfcation Discard Seal, Empty & Replace Cap PLASTIC BOTTLE how2recycle.info

• Jun 28, 2013ANDAANDA203605Mcprf
• Nov 19, 2014ANDAANDA204328The Feinstein Inst
• Jan 9, 2015ANDAANDA204351Biomedcl Res Fdn
• Feb 27, 2015ANDAANDA204542Precision Nuclear
• Apr 20, 2015ANDAANDA204497Univ Utah Cyclotron
• Jul 30, 2015ANDAANDA203780Cardinal Health 414
• Aug 18, 2015ANDAANDA203592Sofie
• Sep 28, 2015ANDAANDA203890Petnet

1. 1Drug Ineffective3848.1%
2. 2Fatigue3667.7%
3. 3Nausea3397.2%
4. 4Pain2996.3%
5. 5Diarrhoea2946.2%
6. 6Vomiting2615.5%
7. 7Pneumonia2425.1%
8. 8Dizziness2415.1%
9. 9Headache2395.1%
10. 10Pyrexia2365.0%
11. 11Dyspnoea2355.0%
12. 12Weight Decreased2324.9%
13. 13Condition Aggravated2284.8%
14. 14Rash2264.8%
15. 15Arthralgia2144.5%

Recent PubMed references pinned to Sodium Fluoride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Melatonin alleviates fluoride-induced developmental neurotoxicity by restoring SIRT3/HIF-1α axis-mediated mitochondrial dysfunction and reversing energy metabolism reprogramming.
  Ecotoxicology and environmental safety · 2026 · Ma R, Wang C, Qin W, et al.
  PMID 42176635DOI 10.1016/j.ecoenv.2026.120301
• Chronic fluoride exposure induces tissue damage, oxidative stress, and immune dysfunction in juvenile crucian carp (Carassius auratus).
  Fish physiology and biochemistry · 2026 · Zhang J, Gao X, Ma J, et al.
  PMID 42154315DOI 10.1007/s10695-026-01697-x
• Probing the Biological Plausibility of Fluoride as an Endocrine Disruptor.
  Birth defects research · 2026 · Mudd AM, Ovando BJ, Daston GP, et al.
  PMID 42138003DOI 10.1002/bdr2.70046
• Microbial alteration after intensive fluoride varnish treatment in children with early childhood caries: An exploratory study.
  Journal of dentistry · 2026 · Li Y, Zhang L, Paster BJ, et al.
  PMID 42061740DOI 10.1016/j.jdent.2026.106720
• Assessment of the remineralizing potential of nano-bioactive glass, nano-hydroxyapatite, and sodium fluoride on artificial carious lesions in primary teeth.
  BMC oral health · 2026 · ElZohairy HA, Nagi BM, Allam GG, et al.
  PMID 42015118DOI 10.1186/s12903-026-08279-6
• Molecular imaging of dural microcalcification: Detection of active mineralization with (18)F-NaF PET/CT.
  Hellenic journal of nuclear medicine · 2026 · Patil S, Gharavi D, Patel N, et al.
  PMID 42001444DOI 10.1967/s002449912948
• Effects of Inorganic Fluoride and the Fluoroquinolone Antibiotic Pefloxacin on the Growth and Microbiome Structure of Eruca sativa L.
  International journal of molecular sciences · 2026 · Kamiński J, Piotrowicz-Cieślak AI
  PMID 41977121DOI 10.3390/ijms27072931
• Adverse effects of sodium fluoride exposure on the development, thyroid morphology and disease resistance in rainbow trout (Oncorhynchus mykiss) embryos and larvae.
  Aquatic toxicology (Amsterdam, Netherlands) · 2026 · Pannetier P, Cachot J, Clérandeau C, et al.
  PMID 41936154DOI 10.1016/j.aquatox.2026.107815

The 10 most recently updated of 651 ClinicalTrials.gov registrations naming Sodium Fluoride as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Bacterial Reduction for a Manual Toothbrush With a 360-Degree Mouth Cleaner Design Versus a Standard Toothbrush
  Completed · Phase 3 · Interventional · 56 enrolled · Colgate Palmolive
  NCT07471477updated 2026-06-12
• Stannous Fluoride Toothpaste for Reduction and Treatment of Gingivitis
  Completed · Interventional · 133 enrolled · Church & Dwight Company, Inc.
  NCT07640399updated 2026-06-10
• F-18 Sodium Fluoride PET/CT Guided Versus Ultrasound- Guided Intra-articular Injections in Chronic Low Backache
  Completed · Interventional · 40 enrolled · Post Graduate Institute of Medical Education and Research, Chandigarh
  NCT07632508updated 2026-06-08
• Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children
  Recruiting · Interventional · 130 enrolled · Anabio R&D
  NCT07241052updated 2026-06-05
• Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer
  Recruiting · Phase 2 · Interventional · 65 enrolled · National Cancer Institute (NCI)
  NCT04981509updated 2026-06-03
• Comparison of the Effectiveness of Miswak and Manual Toothbrush in Removing Dental Plaque in Fixed Orthodontic Patients
  Recruiting · Interventional · 90 enrolled · Al-Hawash Private University
  NCT07619014updated 2026-06-03
• The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries
  Recruiting · Interventional · 80 enrolled · Gül Keskin
  NCT07609797updated 2026-06-02
• Effect of Fluoride Varnish Formulation on the Management of Dentin Hypersensitivity
  Recruiting · Interventional · 92 enrolled · University of Concepcion, Chile
  NCT07286344updated 2026-06-02
• Post-Radiation Oral Health in Underserved Head and Neck Cancer Patients
  Active not recruiting · Interventional · 43 enrolled · University of California, San Francisco
  NCT07556367updated 2026-06-01
• Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis
  Recruiting · Phase 4 · Interventional · 100 enrolled · Colgate Palmolive
  NCT07614490updated 2026-05-29

Frequently asked questions

How does Sodium Fluoride work?

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

What is Sodium Fluoride used for?

According to FDA labeling, Sodium Fluoride carries indications including: Use aids in the prevention of dental cavities. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Sodium Fluoride?

Sodium Fluoride is classified as Caries prophylactic agents, Fluoride, Unknown Cellular or Molecular Interaction, Bone Formation Stimulation.

What are the brand names for Sodium Fluoride?

Sodium Fluoride is marketed under brand names including ACT Fluoride Rinse, Allday, CTx3 Rinse, Clinpro 5000, Colgate, Crest, Denta 5000 Plus, Dentagel.