Stannous Fluoride

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

• Uses aids in the prevention of cavities * helps prevent gingivitis * helps interfere with teh harmful effects of plaque associated with gingivitis * helps control plaque bacteria that contribute to teh development of gingivitis

Directions adults and children 12 years of age and older: brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or physician * do not swallow * children under 12 years of age: ask a dentist

Keep out of reach of children under 12 years of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

1. 1Oral Discomfort10113%
2. 2Drug Ineffective8211%
3. 3Oral Pain516.8%
4. 4Toothache466.1%
5. 5Stomatitis456.0%
6. 6Gingival Pain415.4%
7. 7Oral Mucosal Exfoliation344.5%
8. 8Lip Swelling334.4%
9. 9Tooth Discolouration324.2%
10. 10Ageusia304.0%
11. 11Condition Aggravated304.0%
12. 12Dysgeusia293.8%
13. 13Glossodynia293.8%
14. 14Product Use In Unapproved Indication293.8%
15. 15Hypersensitivity283.7%

Recent PubMed references pinned to Stannous Fluoride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Anhydrous stannous fluoride toothpaste in dentin hypersensitivity: clinician-assessed and patient-reported outcomes from two controlled trials.
  Clinical oral investigations · 2026 · Qiu J, Creeth JE, Mohammad A, et al.
  PMID 42262610DOI 10.1007/s00784-026-06942-4
• Clinical efficacy of a stannous fluoride toothpaste stabilized with zinc phosphate in reducing supragingival calculus formation compared to a sodium monofluorophosphate toothpaste: A randomized controlled trial.
  American journal of dentistry · 2026 · Seriwatanachai D, Kraivaphan P, Amornchat C, et al.
  PMID 42013428
• Effect of Topical Fluoride Application Temperature on Recharge and Rerelease in Different Restorative Materials.
  International dental journal · 2026 · Kim JE, Hong JY, Kim KM, et al.
  PMID 41456542DOI 10.1016/j.identj.2025.109351
• Effects of Stannous Fluoride Toothpaste and Chios Mastiha Toothpaste on the Prevention of Enamel Erosion.
  Oral health & preventive dentistry · 2025 · Chatzidimitriou K, Papageorgiou S, Gizani S, et al.
  PMID 41055112DOI 10.3290/j.ohpd.c_2301
• A 3-month randomized trial evaluating the effects of stannous fluoride bioavailability on gingivitis.
  American journal of dentistry · 2025 · He T, Grender J, Zou Y, et al.
  PMID 40455955
• ANTIPLAQUE AND ANTIGINGIVITIS EFFECTS OF A NOVEL ORAL CARE REGIMEN FEATURING STANNOUS FLUORIDE TOOTHPASTE, A UNIQUE TOOTHBRUSH, AND CETYLPYRIDINIUM CHLORIDE MOUTHWASH: A RANDOMIZED CLINICAL TRIAL.
  The journal of evidence-based dental practice · 2025 · Ayad F, Hetata M, Ahmed R, et al.
  PMID 40335199DOI 10.1016/j.jebdp.2025.102123
• Clinical effects of stannous fluoride dentifrice on peri-implant mucositis, plaque microbiome, and oxidative stress.
  American journal of dentistry · 2025 · Klukowska M, Ramji N, Muñoz Bodnar A, et al.
  PMID 40324037
• Role of Amine and/or Tin-Containing Dentifrices on Tooth Discoloration and Surface Properties.
  Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025 · Maia MB, Tawil T, Vardasca IS, et al.
  PMID 39949122DOI 10.1111/jerd.13439

The 10 most recently updated of 131 ClinicalTrials.gov registrations naming Stannous Fluoride as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Stannous Fluoride Toothpaste for Reduction and Treatment of Gingivitis
  Completed · Interventional · 133 enrolled · Church & Dwight Company, Inc.
  NCT07640399updated 2026-06-10
• Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes
  Enrolling by invitation · Phase 4 · Interventional · 10,000 enrolled · Colgate Palmolive
  NCT07619729updated 2026-06-03
• To Assess the Efficacy of Two Brushing Regimens: in the Reduction of Established Dental Plaque and Gingivitis.
  Active not recruiting · Phase 3 · Interventional · 85 enrolled · Colgate Palmolive
  NCT07605338updated 2026-05-27
• Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.
  Not yet recruiting · Phase 4 · Interventional · 20 enrolled · Colgate Palmolive
  NCT06966492updated 2026-05-26
• Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.
  Completed · Phase 3 · Interventional · 134 enrolled · Colgate Palmolive
  NCT07398846updated 2026-05-22
• Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control.
  Completed · Phase 2 · Interventional · 120 enrolled · Procter and Gamble
  NCT06892834updated 2026-05-04
• A Clinical Study to Evaluate the Effectiveness of an Test Toothpaste for the Relief of Dentin Hypersensitivity in a Chinese Population
  Completed · Interventional · 177 enrolled · HALEON
  NCT07352956updated 2026-04-14
• Effect of CPP-ACP Associated With NaF or SnF₂ on Post-Bleaching Tooth Sensitivity
  Completed · Interventional · 64 enrolled · Universidade Federal do Para
  NCT07506850updated 2026-04-02
• Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.
  Completed · Phase 3 · Interventional · 82 enrolled · Colgate Palmolive
  NCT06244303updated 2026-03-19
• The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis.
  Completed · Phase 3 · Interventional · 95 enrolled · Colgate Palmolive
  NCT06427499updated 2026-03-19

Frequently asked questions

How does Stannous Fluoride work?

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

What is Stannous Fluoride used for?

According to FDA labeling, Stannous Fluoride carries indications including: Uses aids in the prevention of cavities * helps prevent gingivitis * helps interfere with teh harmful effects of plaque associated with gingivitis * helps control plaque bacteria that contribute to teh development of gingivitis. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Stannous Fluoride?

Stannous Fluoride is classified as Caries prophylactic agents, Unknown Cellular or Molecular Interaction, Bone Alteration.

What are the brand names for Stannous Fluoride?

Stannous Fluoride is marketed under brand names including Dental Resources Perio Maintenance Rinse, Dental Resources brand of Stannous Fluoride, Doctor's Choice, Gel-Kam, Gelato Perio Rinse, Gingi Med, Kid's Choice, MedActive Rinse.