Streptozocin

Mechanism-of-action classes: Alkylating Activity; Nucleic Acid Synthesis Inhibitors.

Reference statistics from the openFDA drug-shortage dataset. For a live view, consult the FDA database directly. Not clinical guidance.

• Zanosar, Powder, For Solution, 1 g/10 mL (NDC 68118-100-01)Active
  Sponsor: ESTEVE PHARMACEUTICALS, S.A.
  Updated May 6, 2026
• Zanosar, Powder, For Solution, 100 mg/1 mL (NDC 0703-4636-01)Active
  Sponsor: Teva Pharmaceuticals USA, Inc. · Reason: Other
  Updated Jun 2, 2026

1. 1Malignant Neoplasm Progression5725%
2. 2Product Use In Unapproved Indication4018%
3. 3Pancreatic Neuroendocrine Tumour3717%
4. 4Drug Ineffective3516%
5. 5Hypoglycaemia3516%
6. 6Fatigue3415%
7. 7Nausea2913%
8. 8Off Label Use2813%
9. 9Disease Progression2411%
10. 10Weight Decreased208.9%
11. 11Decreased Appetite188.0%
12. 12Toxicity To Various Agents188.0%
13. 13Chronic Kidney Disease177.6%
14. 14Dry Mouth177.6%
15. 15Nephropathy Toxic177.6%

Recent PubMed references pinned to Streptozocin as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Streptozotocin revisited: Pharmacological determinants supporting new scheduling strategies in neuroendocrine tumours.
  Cancer treatment reviews · 2026 · Fazio N, Spada F, Benini L, et al.
  PMID 42061024DOI 10.1016/j.ctrv.2026.103140
• Capsaicin Mitigates Insulin Resistance-Driven Prostate Hyperplasia Via IGF-1 Signalling Modulation in HFD + STZ Rat Model.
  Journal of biochemical and molecular toxicology · 2026 · Kotaru M, Ranjan Das N
  PMID 41987603DOI 10.1002/jbt.70845
• The antineoplastic agent streptozotocin induces short-term telomere instability in Epstein-Barr virus-transformed human lymphoblastoid cells.
  Experimental cell research · 2026 · Cardozo AG, Castrogiovanni DC, Parisi J, et al.
  PMID 41887450DOI 10.1016/j.yexcr.2026.114998
• Comparative analysis of dose-response variability and severity in STZ-induced diabetes: female vs. male NSG mice.
  Scientific reports · 2026 · Talbot SR, Heider M, Wirth M, et al.
  PMID 41786859DOI 10.1038/s41598-026-42408-z
• Repeated low-dose streptozotocin induces latent renal proximal tubular injury independently of blood glucose.
  Molecular and cellular endocrinology · 2026 · Nakamura M, Nakai K, Tsujinaka-Sawai E, et al.
  PMID 41679693DOI 10.1016/j.mce.2026.112756
• Hentriacontane alleviates streptozotocin-induced Alzheimer's disease-like conditions in rats: In silico and in vivo investigations revealed the unifying principles.
  Computers in biology and medicine · 2026 · More SA, Sikkalgar A, Chourasiya N, et al.
  PMID 41666657DOI 10.1016/j.compbiomed.2026.111513
• A Streptozotocin-Induced Mouse Model of Renal Tumors: Histopathological and Immunohistochemical Comparisons With Human Chromophobe Renal Cell Carcinoma.
  Toxicologic pathology · 2026 · Fukuma Y, Mori H, Tanaka T, et al.
  PMID 41457354DOI 10.1177/01926233251400265
• Dose dependent toxicity of streptozotocin inducing diabetic complications in male Sprague Dawley rats with metabolic biochemical histopathological effects.
  Scientific reports · 2025 · Sedik AA, El-Mosallamy AEMK, Yassen NN, et al.
  PMID 41361213DOI 10.1038/s41598-025-27100-y

The 10 most recently updated of 17 ClinicalTrials.gov registrations naming Streptozocin as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia
  Recruiting · Phase 3 · Interventional · 140 enrolled · AstraZeneca
  NCT03813407updated 2026-05-15
• MGMT-NET: O6-methylguanine-DNA Methyltransferase (MGMT) Status in Neuroendocrine Tumors: Predictive Factor of Response to Alkylating Agents
  Completed · Interventional · 116 enrolled · Hospices Civils de Lyon
  NCT03217097updated 2025-11-21
• The Effect of Sitagliptin, Pioglitazone and Dapagliflozine on Myocardial Infarction in Diabetic Rats
  Completed · Phase 4 · Interventional · 50 enrolled · Al-Azhar University
  NCT07083232updated 2025-08-14
• Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy
  Recruiting · Phase 2 · Interventional · 60 enrolled · Ain Shams University
  NCT07036796updated 2025-08-06
• Sequentiality of Everolimus and STZ-5FU in Advanced Pancreatic Neuroendocrine Tumor
  Completed · Phase 3 · Interventional · 141 enrolled · Grupo Espanol de Tumores Neuroendocrinos
  NCT02246127updated 2025-05-11
• Two Chemotherapy Regimens Plus or Minus Bevacizumab
  Active not recruiting · Phase 2 · Interventional · 140 enrolled · Gustave Roussy, Cancer Campus, Grand Paris
  NCT03351296updated 2024-05-08
• Reduce Incidence of Pre-Dialysis Hyperkalaemia With Sodium Zirconium Cyclosilicate in Chinese Subjects
  Completed · Phase 3 · Interventional · 134 enrolled · AstraZeneca
  NCT04217590updated 2023-03-28
• Genomic Based Assignment of Therapy in Advanced Urothelial Carcinoma
  Completed · Phase 2 · Interventional · 8 enrolled · National Cancer Institute (NCI)
  NCT02788201updated 2020-11-06
• Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients
  Unknown · Phase 2 · Phase 3 · Interventional · 200 enrolled · Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd
  NCT03758014updated 2018-11-29
• A Study of the Safety and Efficacy of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Pediatric Participants (MK-0869-208)
  Completed · Phase 3 · Interventional · 307 enrolled · Merck Sharp & Dohme LLC
  NCT01362530updated 2018-09-25

Frequently asked questions

How does Streptozocin work?

Mechanism-of-action classes: Alkylating Activity; Nucleic Acid Synthesis Inhibitors.

What class of drug is Streptozocin?

Streptozocin is classified as Nitrosoureas, Alkylating Drug, Alkylating Activity, Nucleic Acid Synthesis Inhibitors, Decreased DNA Integrity, Decreased Protein Modification, Decreased RNA Integrity.

What are the brand names for Streptozocin?

Streptozocin is marketed under brand names including Zanosar.