Succinate

• Use helps to reduce difficulty in falling asleep

Directions adults and children 12 years of age and over: take one tablet 30 minutes before going to bed; take once daily or as directed by a doctor children under 12 years of age: do not use

Do not use in children under 12 years of age with any other product containing doxylamine unless you have time for a full night’s sleep Ask a doctor before use if you have a breathing problem such as emphysema or chronic bronchitis glaucoma trouble urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are taking sedatives or any other sleep-aid tranquilizers any other antihistamines any other drugs When using this product avoid alcoholic beverages do not drive a motor vehicle or operate machinery take only at bedtime Stop use and ask a doctor if sleeplessness persists continuously for more than two weeks. Insomnia may be a symptom of serious underlying medical illness. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

• Apr 27, 1955NDANDA009866Pharmacia And Upjohn
• May 18, 1959NDANDA011856Pharmacia And Upjohn
• Jan 10, 1992NDANDA019962Melinta Therap
• Nov 19, 2004NDANDA021518Astellas
• Feb 29, 2008NDANDA021992Pf Prism Cv
• Apr 15, 2008NDANDA021926Currax
• Apr 8, 2013NDANDA021876Duchesnay
• Jan 27, 2016NDANDA206099Currax

1. 1Drug Ineffective19,4268.8%
2. 2Off Label Use16,8957.6%
3. 3Fatigue16,0497.2%
4. 4Nausea14,7956.7%
5. 5Headache13,5226.1%
6. 6Diarrhoea11,4975.2%
7. 7Dyspnoea11,4785.2%
8. 8Dizziness11,0405.0%
9. 9Pain10,5754.8%
10. 10Vomiting8,2483.7%
11. 11Malaise8,0683.6%
12. 12Asthenia7,8033.5%
13. 13Arthralgia7,5983.4%
14. 14Rash7,4403.4%
15. 15Pneumonia7,1373.2%

Recent PubMed references pinned to Succinate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• [Sleep disorders and chronic cerebral ischemia].
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026 · Putilina MV
  PMID 42268271DOI 10.17116/jnevro202612605242
• Network Pharmacology and in vitro Experimental Validation Reveal the Anticancer Mechanisms of Cichoric Acid in Cervical Cancer.
  Annals of clinical and laboratory science · 2026 · Zhou J, Huang Q, Yang H, et al.
  PMID 42259545
• Succinate drives breast cancer bone metastasis by activating the HIF1α/YTHDF1/YAP signaling axis to upregulate chemokine CXCL5 and disrupt the bone microenvironment.
  Apoptosis : an international journal on programmed cell death · 2026 · Xue J, Zhu C, Zhai Y, et al.
  PMID 42228026DOI 10.1007/s10495-026-02361-8
• Mechanisms Involved in Pathological Succinate-Mediated Signaling.
  International journal of molecular sciences · 2026 · Bernabe-Yepes B, Zazueta C
  PMID 42196310DOI 10.3390/ijms27104328
• Biphasic modulation of hen egg white lysozyme amyloid aggregation by dioctyl sulfosuccinate sodium: Effects of cosolutes.
  International journal of biological macromolecules · 2026 · Malik A, Alamri A, Khan JM, et al.
  PMID 42184852DOI 10.1016/j.ijbiomac.2026.152691
• Succinylation in cancer immunotherapy: mechanisms, biomarkers, and therapeutic implications.
  Frontiers in immunology · 2026 · Xie P, Long MH, Liu ZQ, et al.
  PMID 42183207DOI 10.3389/fimmu.2026.1794817
• Synthesis of octenyl succinic anhydride-modified corn starch: Focusing on the C2, C3 and C6 substitution positions of anhydroglucose units.
  Food chemistry · 2026 · Gao W, Chen Y, Cheng Y, et al.
  PMID 42143510DOI 10.1016/j.foodchem.2026.149628
• Albiflorin contributes to Xuebijing-mediated protection against sepsis-associated acute kidney injury by modulating the succinate-PFKFB3 immunometabolic axis.
  International immunopharmacology · 2026 · Xu Y, Wei J, Chen M, et al.
  PMID 42134292DOI 10.1016/j.intimp.2026.116841

The 10 most recently updated of 633 ClinicalTrials.gov registrations naming Succinate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
  Recruiting · Phase 2 · Interventional · 461 enrolled · National Cancer Institute (NCI)
  NCT04546399updated 2026-06-12
• Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial
  Recruiting · Phase 3 · Interventional · 1,978 enrolled · National Cancer Institute (NCI)
  NCT07391774updated 2026-06-12
• Siplizumab for Sickle Cell Disease Transplant
  Terminated · Phase 1 · Phase 2 · Interventional · 1 enrolled · Columbia University
  NCT06078696updated 2026-06-10
• Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM
  Completed · Phase 3 · Interventional · 175 enrolled · Cytokinetics
  NCT05767346updated 2026-06-09
• Efficacy of Solifenacin, Mirabegron and Combination Therapy in Children With Daytime Urinary Incontinence (BeDry)
  Recruiting · Phase 3 · Interventional · 236 enrolled · University of Aarhus
  NCT06551246updated 2026-06-08
• Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry)
  Active not recruiting · Phase 4 · Interventional · 216 enrolled · University of Aarhus
  NCT06465576updated 2026-06-08
• A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats
  Completed · Observational · 999 enrolled · Astellas Pharma Global Development, Inc.
  NCT06049797updated 2026-06-05
• Evaluation of Corticosteroid Administration Following Impacted Third Molar Surgery Using 3-Dimensional Facial Analysis
  Completed · Interventional · 60 enrolled · Irfan Üstündağ
  NCT07628166updated 2026-06-04
• Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma
  Active not recruiting · Phase 3 · Interventional · 847 enrolled · National Cancer Institute (NCI)
  NCT02112916updated 2026-06-03
• Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis
  Terminated · Phase 2 · Interventional · 1 enrolled · ECOG-ACRIN Cancer Research Group
  NCT04438382updated 2026-06-02

Frequently asked questions

What is Succinate used for?

According to FDA labeling, Succinate carries indications including: Use helps to reduce difficulty in falling asleep. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.