Tetrahydrozoline

Mechanism-of-action class: Adrenergic alpha-Agonists.

• Use relieves redness of the eye due to minor eye irritations

Directions instill 1 to 2 drops in the affected eye(s) up to 4 times daily

For external use only Ask a doctor before use if you have narrow angle glaucoma When using this product pupils may become enlarged temporarily to avoid contamination, do not touch tip of container to any surface. Replace cap after using. if solution changes color or becomes cloudy, do not use overuse may produce increased redness of the eye remove contact lenses before using Stop use and ask a doctor if you experience eye pain changes in vision continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

1. 1Fatigue10532%
2. 2Headache9730%
3. 3Off Label Use9629%
4. 4Drug Ineffective9529%
5. 5Pain9228%
6. 6Rash9128%
7. 7Abdominal Discomfort8827%
8. 8Weight Decreased8827%
9. 9Inappropriate Schedule Of Product Administration8727%
10. 10Pyrexia8727%
11. 11Condition Aggravated8526%
12. 12Pain In Extremity8526%
13. 13Tinnitus8526%
14. 14Confusional State8426%
15. 15Dysgeusia8426%

The 10 most recently updated of 26 ClinicalTrials.gov registrations naming Tetrahydrozoline as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Volumetric Visual Fields at Intermediate and Near Distances in Presbyopic Patients Using Occupational and General-Purpose Progressive Addition Lenses
  Active not recruiting · Interventional · 26 enrolled · University of Seville
  NCT07617090updated 2026-06-01
• Visual and Patient-Reported Outcomes After Bilateral Non-Diffractive EDOF IOL Implantation
  Completed · Interventional · 30 enrolled · Benha University
  NCT07457216updated 2026-03-09
• Comparison of Visual Outcomes and Patient Satisfaction in Mild to Moderate Glaucoma Patients Undergoing Cataract Surgery With EDOF Versus Monofocal IOLs
  Not yet recruiting · Interventional · 74 enrolled · OMIQ Research
  NCT07436871updated 2026-02-27
• Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy
  Recruiting · Phase 2 · Interventional · 45 enrolled · Massachusetts Eye and Ear Infirmary
  NCT04440280updated 2025-09-29
• Atropine and Spectacle Combination Treatment (ASPECT): 12-month Results of a Randomized Clinical Trial for Myopia Control
  Active not recruiting · Phase 4 · Interventional · 111 enrolled · Hospital San Carlos, Madrid
  NCT06431841updated 2025-09-11
• Toric Intraocular Lens Implantation for Pediatric Aphakia
  Completed · Interventional · 236 enrolled · Eye & ENT Hospital of Fudan University
  NCT07088796updated 2025-09-08
• Amara View Benchmark Study
  Completed · Interventional · 35 enrolled · Philips Clinical & Medical Affairs Global
  NCT06535932updated 2025-08-03
• Instant Flush Redness Clinical Efficacy Study
  Not yet recruiting · Interventional · 60 enrolled · ChinaNorm
  NCT07067476updated 2025-07-16
• Reducing Aerosol and Bioaerosol Using Different Oral Suctions
  Completed · Interventional · 50 enrolled · King Abdulaziz University
  NCT05848245updated 2025-04-16
• Effect of Spectacle Distribution to Myopic Secondary School Students in Rural Communities of Liaoning Province on Communities Academic High School Enrolment
  Not yet recruiting · Interventional · 1,980 enrolled · He Eye Hospital
  NCT06714994updated 2024-12-04

Frequently asked questions

How does Tetrahydrozoline work?

Mechanism-of-action class: Adrenergic alpha-Agonists.

What is Tetrahydrozoline used for?

According to FDA labeling, Tetrahydrozoline carries indications including: Use relieves redness of the eye due to minor eye irritations. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Tetrahydrozoline?

Tetrahydrozoline is classified as Sympathomimetics, combinations excl. corticosteroids, Sympathomimetics, plain, Sympathomimetics used as decongestants, Adrenergic alpha-Agonists, Conjunctival Arterial Vasoconstriction, Decreased Nasal and Sinus Secretions.

What are the brand names for Tetrahydrozoline?

Tetrahydrozoline is marketed under brand names including Altazine, Optigene, Visine.