Triclosan

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

• Uses for handwashing to decrease bacteria on the skin

Directions wet skins and apply a small amount on hands an forearms scrub well, rinse thoroughly and dry

For external use only Do not use in eyes When using this product if in eyes, rinse promptly and thoroughly with water discontinue use if irritation and redness develop Stop use and ask a doctor if skin irritation or redness occurs for more than 72 hours Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

1. 1Weight Increased19940%
2. 2Type 2 Diabetes Mellitus19839%
3. 3Vomiting18837%
4. 4Urticaria18637%
5. 5Hypertension18437%
6. 6Hypoaesthesia18136%
7. 7Irritable Bowel Syndrome17435%
8. 8Osteoarthritis17435%
9. 9Infusion Related Reaction17334%
10. 10Wound Infection17234%
11. 11Joint Range Of Motion Decreased16934%
12. 12Joint Stiffness16934%
13. 13Joint Dislocation16833%
14. 14Nasopharyngitis16833%
15. 15Wound16833%

Recent PubMed references pinned to Triclosan as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Triclosan as a selective pressure on nitrifying microbial guilds: functional, genetic, and biogeochemical perspectives.
  Aquatic toxicology (Amsterdam, Netherlands) · 2026 · Varghese P, Kumar K, Yun K, et al.
  PMID 42208386DOI 10.1016/j.aquatox.2026.107877
• Maternal triclosan exposure impairs female offspring neurodevelopment via MeCP2 hypomethylation and enhanced MeCP2/HDAC3 interaction.
  Ecotoxicology and environmental safety · 2026 · Hao W, Xianjia L, Mengjun C, et al.
  PMID 42172708DOI 10.1016/j.ecoenv.2026.120282
• Molecular disruption of neuroinflammatory and metabolic pathways mediates triclosan-induced depressive-like behavior in zebrafish.
  Toxicology and applied pharmacology · 2026 · Wang D, Liu J, Zhou R, et al.
  PMID 42162926DOI 10.1016/j.taap.2026.117881
• Development and validation of a GC-MS method for the simultaneous determination of bisphenols, phthalate monoesters, and triclosan in human meconium for comprehensive prenatal exposure assessment.
  Journal of pharmaceutical and biomedical analysis · 2026 · Tok KC, Gumustas M, Masoud KM, et al.
  PMID 42155372DOI 10.1016/j.jpba.2026.117556
• Synergistic Toxicity Assessment of Triclosan and Co-occurring Chemicals in Household Cleaning Products: Regulatory Insights for Consumer Chemical Management.
  Environmental science & technology · 2026 · Jung Y, Kim D, Choi J, et al.
  PMID 42133483DOI 10.1021/acs.est.6c01360
• Triclosan exposure perturbs skin lipid metabolism and inflammatory pathways: Insights from network toxicology and multi-omics analyses.
  Environmental pollution (Barking, Essex : 1987) · 2026 · Luo X, Jin Y, Yang S, et al.
  PMID 42061800DOI 10.1016/j.envpol.2026.128223
• Comprehensive overview of triclosan neurotoxicity and construction of adverse outcome pathways using a systems toxicology approach: Triclosan-induced attention-deficit hyperactivity disorder as an example.
  Ecotoxicology and environmental safety · 2026 · Shang J, Cui H, Shu C, et al.
  PMID 42034588DOI 10.1016/j.ecoenv.2026.120169
• Clinical outcomes of closuring technique in total hip arthroplasty and total knee arthroplasty: A comparative study of staples technique vs triclosan-coated barbed sutures.
  Revista espanola de cirugia ortopedica y traumatologia · 2025 · Benkovich V, Abialevich A, Benkovich G, et al.
  PMID 42024072DOI 10.1016/j.recot.2025.07.010

The 10 most recently updated of 92 ClinicalTrials.gov registrations naming Triclosan as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients
  Not yet recruiting · Phase 4 · Interventional · 401 enrolled · Unity Health Toronto
  NCT07507409updated 2026-04-13
• Antibiotic-coated Braided Suture Study
  Not yet recruiting · Interventional · 142 enrolled · University of Miami
  NCT07322289updated 2026-03-23
• Intervascular Post-Market Clinical Follow-Up (PMCF) Registry
  Recruiting · Observational · 1,200 enrolled · Intervascular
  NCT07322913updated 2026-03-12
• Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery
  Recruiting · Interventional · 14 enrolled · University of Medicine and Pharmacy at Ho Chi Minh City
  NCT07386366updated 2026-02-04
• Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy
  Recruiting · Interventional · 436 enrolled · The Cleveland Clinic
  NCT07318493updated 2026-01-21
• Prospective Randomized Trial On Episiorrhaphy
  Active not recruiting · Interventional · 100 enrolled · ASST Fatebenefratelli Sacco
  NCT07045285updated 2025-07-02
• Endocrine Disruptors, Toxic and Essential Chemical Elements and Polycystic Ovary Syndrome
  Completed · Observational · 70 enrolled · University Medical Centre Ljubljana
  NCT06968455updated 2025-05-13
• A Prospective Cohort Pilot Study of the Clinical and Molecular Epidemiology of Staphylococcus Aureus in Pregnant Women at the Time of Group B Streptococcal Screening in a Large Urban Medical Center in Chicago, IL USA
  Completed · Interventional · 107 enrolled · Ann & Robert H Lurie Children's Hospital of Chicago
  NCT00532324updated 2025-03-28
• Antibacterial-coated Sutures at Time of Cesarean
  Completed · Phase 4 · Interventional · 1,122 enrolled · The University of Texas Medical Branch, Galveston
  NCT03386240updated 2025-01-06
• Comparison Of Outcome Of Antibiotic Coated Vicryl Vs Non-Coated Vicryl In Abdominal Fascial Closure After Laparotomy In Children
  Completed · Interventional · 100 enrolled · Muhammad Adeel Ashiq
  NCT06129773updated 2024-02-16

Frequently asked questions

How does Triclosan work?

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

What is Triclosan used for?

According to FDA labeling, Triclosan carries indications including: Uses for handwashing to decrease bacteria on the skin. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Triclosan?

Triclosan is classified as Medicated dressings with antiinfectives, Phenol and derivatives, Unknown Cellular or Molecular Interaction, Unknown Physiological Effect.