Tripelennamine

Mechanism-of-action classes: Histamine H1 Receptor Antagonists; Monoamine Oxidase Inhibitors.

• Use Temporarily relieves pain and itching associated with: • insect bites • minor burns • minor cuts • minor skin irritations • scrapes • sunburn • rashes due to poison ivy, poison oak, or poison sumac

Directions Adults and children 2 years of age and older: Apply to affected area not more than 3 to 4 times daily. Children under 2 years of age: Do not use, consult a physician. Storage Information: Protect from freezing and excessive heat, store at 68°-77°F (20°-25°C).

For external use only. Avoid contact with the eyes. If condition worsens, or if symptoms persist for more than 7 days or clear up and occur again within a few days, discontinue use of this product and consult a physician. Do not use if packaging is damaged or opened. If pregnant or breast-feeding, ask a health professional before use Keep out of reach of children and pets. If swallowed, get medical help or contact Poison Control Center right away.

Recent PubMed references pinned to Tripelennamine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Green micellar liquid chromatographic method for simultaneous determination of antihistaminic drugs tripelennamine hydrochloride and diphenhydramine in pharmaceutical gel.
  Journal of separation science · 2024 · Hammad SF, El-Malla SF, El-Khateeb BZ, et al.
  PMID 38286731DOI 10.1002/jssc.202300757
• HPLC method for identification and quantification of three active substances in a dermatological preparation--Viosept ointment.
  Acta poloniae pharmaceutica · 2014 · Podolska M, Kulik A, Białecka W, et al.
  PMID 25362799
• H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds.
  Journal of applied physiology (Bethesda, Md. : 1985) · 2002 · Manohar M, Goetz TE, Humphrey S, et al.
  PMID 11896018DOI 10.1152/japplphysiol.00925.2001
• Lack of effect of repeated administration of tripelennamine on antipyrine disposition in camels.
  Journal of veterinary pharmacology and therapeutics · 2000 · Wasfi IA, Boni NS, Elghazali M, et al.
  PMID 11168921DOI 10.1046/j.1365-2885.2000.00296.x
• Comparative disposition of tripelennamine in horses and camels after intravenous administration.
  Journal of veterinary pharmacology and therapeutics · 2000 · Wasfi IA, Abdel Hadi AA, Elghazali M, et al.
  PMID 11110101DOI 10.1046/j.1365-2885.2000.00261.x
• The discriminative stimulus effects of tripelennamine in humans.
  Psychopharmacology · 1996 · Johanson CE, Evans S, Henningfield J, et al.
  PMID 8856833DOI 10.1007/BF02246349
• Construction and evaluation of PVC conventional and tubular tripelennamine-selective electrodes: their application in pharmaceutical preparations.
  Journal of pharmaceutical and biomedical analysis · 1996 · Lima JL, Montenegro MC, Sales MG, et al.
  PMID 8817997DOI 10.1016/0731-7085(95)01710-0
• Intravenous tripelennamine abuse in schizophrenia.
  Canadian journal of psychiatry. Revue canadienne de psychiatrie · 1996 · Addington J, el-Guebaly N
  PMID 8919430

The 1 most recently updated of 1 ClinicalTrials.gov registrations naming Tripelennamine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-pulmonary Bypass
  Terminated · Interventional · 87 enrolled · The Cleveland Clinic
  NCT00620945updated 2017-12-19

Frequently asked questions

How does Tripelennamine work?

Mechanism-of-action classes: Histamine H1 Receptor Antagonists; Monoamine Oxidase Inhibitors.

What is Tripelennamine used for?

According to FDA labeling, Tripelennamine carries indications including: Use Temporarily relieves pain and itching associated with: • insect bites • minor burns • minor cuts • minor skin irritations • scrapes • sunburn • rashes due to poison ivy, poison oak, or poison sumac. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Tripelennamine?

Tripelennamine is classified as Antihistamines for topical use, Substituted ethylene diamines, Histamine H1 Receptor Antagonists, Monoamine Oxidase Inhibitors, Decreased Histamine Activity.

What are the brand names for Tripelennamine?

Tripelennamine is marketed under brand names including Re-Covr.