Trolamine Salicylate

Mechanism-of-action class: Cyclooxygenase Inhibitors.

• Use For temporarily relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, lumbago, neuralgia, strains, bruises, and sprains

Directions adults and children 12 years and older: massage a liberal amount into the affected area three or four times a day, especially before retiring children under 12 years of age: consult your doctor

For external use only. Use only as directed

1. 1Drug Ineffective3518%
2. 2Nausea2010%
3. 3Fatigue189.1%
4. 4Pain168.1%
5. 5Diarrhoea147.1%
6. 6Dizziness147.1%
7. 7Death136.6%
8. 8Off Label Use126.1%
9. 9Arthralgia94.5%
10. 10Back Pain63.0%
11. 11Dyspnoea63.0%
12. 12Headache63.0%
13. 13No Adverse Event63.0%
14. 14Pain In Extremity63.0%
15. 15Product Use In Unapproved Indication63.0%

Recent PubMed references pinned to Trolamine Salicylate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Salicylate-based analgesic balm attenuates pressor responses from skeletal muscle.
  Medicine and science in sports and exercise · 2007 · Ragan BG, Nelson AJ, Bell GW, et al.
  PMID 17986901DOI 10.1249/mss.0b013e31814fb6b0
• Use of ferric chloride to identify salicylate-containing poisons.
  Journal of toxicology. Clinical toxicology · 2002 · Hoffman RJ, Nelson LS, Hoffman RS, et al.
  PMID 12215048DOI 10.1081/clt-120014643
• Self promotion of deep tissue penetration and distribution of methylsalicylate after topical application.
  Pharmaceutical research · 1999 · Cross SE, Megwa SA, Benson HA, et al.
  PMID 10213375DOI 10.1023/a:1018834021066
• Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies.
  British journal of clinical pharmacology · 1998 · Cross SE, Anderson C, Roberts MS, et al.
  PMID 9690946DOI 10.1046/j.1365-2125.1998.00045.x
• Serum concentrations of salicylic acid following topically applied salicylate derivatives.
  The Annals of pharmacotherapy · 1996 · Morra P, Bartle WR, Walker SE, et al.
  PMID 8876850DOI 10.1177/106002809603000903
• Percutaneous absorption of salicylates from some commercially available topical products containing methyl salicylate or salicylate salts in rats.
  The Journal of pharmacy and pharmacology · 1995 · Megwa SA, Benson HA, Roberts MS, et al.
  PMID 8708981DOI 10.1111/j.2042-7158.1995.tb03266.x
• The apical seal of root canal sealing cements using a radionuclide detection technique.
  International endodontic journal · 1992 · Canalda-Sahli C, Brau-Aguade E, Sentis-Vilalta J, et al.
  PMID 1337901DOI 10.1111/j.1365-2591.1992.tb01158.x
• Antimicrobial activity of seven root canal sealers. Results of agar diffusion and agar dilution tests.
  Oral surgery, oral medicine, and oral pathology · 1992 · Pumarola J, Berastegui E, Brau E, et al.
  PMID 1508532DOI 10.1016/0030-4220(92)90386-5

The 10 most recently updated of 13 ClinicalTrials.gov registrations naming Trolamine Salicylate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Clinical Study on the Prevention and Treatment of Radiation Vaginitis With Triethanolamine Cream
  Not yet recruiting · Phase 4 · Interventional · 238 enrolled · Fujian Cancer Hospital
  NCT07492654updated 2026-03-25
• Efficacy of Fullerene in Preventing Radiation Dermatitis in Patients With Head and Neck Cancer .
  Completed · Interventional · 132 enrolled · West China Hospital
  NCT06484166updated 2025-06-04
• Clinical Observation of Drug Retention Enema in Preventing Acute Radiation-induced Rectal Injury
  Recruiting · Interventional · 200 enrolled · Fujian Cancer Hospital
  NCT06325982updated 2024-06-05
• Topical Composition Therapy for the Treatment of Cutaneous Mastocytosis
  Terminated · Phase 2 · Interventional · 1 enrolled · Joseph Butterfield
  NCT04846348updated 2024-04-25
• Assessing the Efficacy of a Hydrogen Peroxide Gel for Oral Wound Healing and Oral Hygiene
  Completed · Interventional · 54 enrolled · National and Kapodistrian University of Athens
  NCT06370260updated 2024-04-17
• Topical Piroxicam vs Soulagel in the Treatment of Acute Extremity Pain After Emergency Department Discharge
  Completed · Phase 2 · Phase 3 · Interventional · 1,525 enrolled · University of Monastir
  NCT05054023updated 2022-06-21
• Clinical Adhesion Study Between ZTlido 1.8% and Three Over-the-counter External Analgesic Lidocaine-containing Patches
  Completed · Phase 1 · Interventional · 24 enrolled · Scilex Pharmaceuticals, Inc.
  NCT05106400updated 2021-11-03
• Study to Determine Skin Irritation and/or Sensitization Potential of an Antifungal Cream Containing Trolamine (Repeated Insult Patch Test)
  Completed · Phase 3 · Interventional · 225 enrolled · Bayer
  NCT04531540updated 2020-11-17
• Study to Find Out if Cream V61-044 Used to Treat Fungal Infections Causes an Allergic Skin Reaction to Sunlight in Healthy Participants
  Completed · Phase 3 · Interventional · 137 enrolled · Bayer
  NCT04532164updated 2020-11-16
• Study to Learn More About the Potential of Antifungal Cream V61-044 Containing Trolamine to Cause Irritant Reaction of the Skin to Ultra Violet Light in Healthy Human Subjects
  Completed · Phase 3 · Interventional · 32 enrolled · Bayer
  NCT04531527updated 2020-11-13

Frequently asked questions

How does Trolamine Salicylate work?

Mechanism-of-action class: Cyclooxygenase Inhibitors.

What is Trolamine Salicylate used for?

According to FDA labeling, Trolamine Salicylate carries indications including: Use For temporarily relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, lumbago, neuralgia, strains, bruises, and sprains. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Trolamine Salicylate?

Trolamine Salicylate is classified as Cyclooxygenase Inhibitors, Decreased Prostaglandin Production.

What are the brand names for Trolamine Salicylate?

Trolamine Salicylate is marketed under brand names including Arthur Itis, Aspercreme, Mobisyl, Myoflex, Salicor, Sportscreme, Tru-micin.