Vitamin D3

• Folixate ™ is indicated for dietary management of patients with unique nutritional needs requiring increased folate level and Vitamin D supplementation. Folixate™ can be taken by women of childbearing age, pregnant women, and lactating and nonlactating mothers.

• This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Folixate ™ is contraindicated in patients with hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of Vitamin D, and hypervitaminosis D.contraindicated

Take one tablet daily or as directed by a licensed healthcare practitioner.

Tell your doctor if you have: kidney problems, thyroid disease. This medication should be used as directed during pregnancy or while breast-feeding. Consult your doctor about the risks and benefits. Folate alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where Vitamin B12 is deficient. Folate in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations progress.

Allergic sensitization has been reported following both oral and parenteral administration of folate. You should call your doctor for medical advice about serious adverse events. To report adverse side effects or to obtain product information, contact PureTek Corporation, at 1-877-921-7873.

1. 1Nausea3415%
2. 2Dyspnoea219.4%
3. 3Diarrhoea188.1%
4. 4Abdominal Pain177.6%
5. 5Asthenia167.2%
6. 6Dizziness167.2%
7. 7Fatigue167.2%
8. 8Haemoglobin Decreased156.7%
9. 9Headache156.7%
10. 10Pneumonia156.7%
11. 11Vomiting146.3%
12. 12Arthralgia125.4%
13. 13Fall125.4%
14. 14Anaemia104.5%
15. 15Malaise104.5%

Recent PubMed references pinned to Vitamin D3 as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Intravital Monitoring of Psoriasis Treatment Response and Drug Delivery Using Multiphoton Fluorescence Lifetime Imaging.
  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026 · Nguyen L, Mess C, Herberger K, et al.
  PMID 42277626DOI 10.1111/srt.70367
• OPN1SW Modulates UVB-Associated DHCR7 Reduction and Associated 25(OH)D3 and Sterol-Pool Responses in Keratinocytes.
  Experimental dermatology · 2026 · Yang Y, Zeng W, Chen G, et al.
  PMID 42223015DOI 10.1111/exd.70285
• Unveiling the Anti-tumor Actions and Therapeutic Potential of Calcitriol in Colorectal Cancer.
  Anticancer research · 2026 · Rafique A, Koh YS
  PMID 42203331DOI 10.21873/anticanres.18175
• Associations Between Concentrations of Vitamin D3, Vitamin B12, and Folate and the Well-Being of Medical Students.
  Nutrients · 2026 · Cieślikiewicz B, Bieńkowska A, Maksymowicz S, et al.
  PMID 42197019DOI 10.3390/nu18101559
• Targeting dysregulated glycolysis in type 2 diabetic osteoporosis: Identification of a diagnostic gene signature and therapeutic validation of calcifediol.
  Life sciences · 2026 · Li M, Li W, Mai G, et al.
  PMID 42184924DOI 10.1016/j.lfs.2026.124473
• 1,25(OH)₂D₃ mitigates bronchopulmonary dysplasia via modulation of the TXNIP-NLRP3-GSDMD signaling pathway.
  Molecular biology reports · 2026 · Chen D, Lin S, Yang L, et al.
  PMID 42183898DOI 10.1007/s11033-026-12016-1
• Potential modulation of ED-71 in regulating H3K18 histone lactylation to suppress osteoclast differentiation and alleviate postmenopausal osteoporosis.
  Biochemical pharmacology · 2026 · Ji Y, Cao T, Rong X, et al.
  PMID 42167450DOI 10.1016/j.bcp.2026.118088
• High-Dose Vitamin D3 Supplementation During Pregnancy and Test-Based Cognitive Performance at Age 10 Years: A Post Hoc Secondary Analysis of a Randomized Clinical Trial.
  JAMA network open · 2026 · Frederiksen OF, Jepsen JRM, Brustad N, et al.
  PMID 42149595DOI 10.1001/jamanetworkopen.2026.11464

The 10 most recently updated of 3,256 ClinicalTrials.gov registrations naming Vitamin D3 as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Host-Diet-Gut Interaction Post Vegan Diet in Pediatric Autoimmune Hepatitis.
  Recruiting · Interventional · 40 enrolled · Institute of Liver and Biliary Sciences, India
  NCT07118657updated 2026-06-12
• Influence of Dermocorticoids on Bone Mineral Density in Patients With Bullous Pemphigoid
  Completed · Phase 4 · Interventional · 47 enrolled · Centre Hospitalier Universitaire, Amiens
  NCT03926377updated 2026-06-12
• Vitamin D in Diabetic Neuropathy
  Not yet recruiting · Phase 2 · Phase 3 · Interventional · 150 enrolled · Tanta University
  NCT07644520updated 2026-06-12
• Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
  Active not recruiting · Phase 3 · Interventional · 67 enrolled · Calcilytix Therapeutics, Inc., a BridgeBio company
  NCT05680818updated 2026-06-11
• Randomized Trial of Enteral Vitamin D Supplementation in Infants < 28 Weeks Gestational Age or <1000 Grams Birth Weight
  Active not recruiting · Interventional · 60 enrolled · The University of Texas Health Science Center, Houston
  NCT05694689updated 2026-06-11
• Effects of High-Dose Vitamin D on Hormones, Neuromuscular Function, Cognition, and Body Composition in Athletes
  Recruiting · Interventional · 200 enrolled · The Jerzy Kukuczka Academy of Physical Education in Katowice
  NCT07641075updated 2026-06-11
• ViDES Trial (Vitamin D Extra Supplementation)
  Active not recruiting · Interventional · 180 enrolled · The University of Texas Health Science Center, Houston
  NCT05459298updated 2026-06-11
• The Effect of Vitamin D Supplementation on the Anti-inflammatory Response in Periodontal Diseases
  Recruiting · Interventional · 120 enrolled · Recep Tayyip Erdogan University Training and Research Hospital
  NCT07636733updated 2026-06-10
• Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome
  Recruiting · Interventional · 56 enrolled · University of Maryland, Baltimore
  NCT05977179updated 2026-06-10
• The Investigation of Vitamin D and Menstrual Cycles Trial, the inVitD Trial: A Phase II Clinical Trial
  Completed · Phase 2 · Interventional · 57 enrolled · National Institute of Environmental Health Sciences (NIEHS)
  NCT05050916updated 2026-06-09

Frequently asked questions

What is Vitamin D3 used for?

According to FDA labeling, Vitamin D3 carries indications including: Folixate ™ is indicated for dietary management of patients with unique nutritional needs requiring increased folate level and Vitamin D supplementation. Folixate™ can be taken by women of childbearing age, pregnant women, and lactating and nonlactating mothers.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What are the contraindications for Vitamin D3?

Vitamin D3 labeling lists contraindications including: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Folixate ™ is contraindicated in patients with hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of Vitamin D, and hypervitaminosis D.. Always consult the full prescribing information and a clinician.