Vitamin K2
US-FDASourced from openFDA
GET
/api/v1/drug/vitamin-k2Indications
Sourced from openFDA- # Suggested areas of application e.g., back of hand, forearm, around knee, back of foot. Avoid using lotions or creams on the application area, as they may hinder absorption.
Dosage & administration
Sourced from openFDAfor external use only
Warnings & precautions
Sourced from openFDADo not use on damaged, broken or irritated skin. Keep out of reach of children 18 years or younger.
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
17 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Nausea529%
- 2Asthenia318%
- 3Condition Aggravated318%
- 4Dyspnoea318%
- 5Haemoglobin Decreased318%
- 6Product Use Issue318%
- 7Anaemia212%
- 8Blood Sodium Decreased212%
- 9Death212%
- 10Decreased Appetite212%
- 11Diarrhoea212%
- 12Disease Progression212%
- 13Feeling Abnormal212%
- 14Haematocrit Decreased212%
- 15Headache212%
Literature
Recent PubMed references pinned to Vitamin K2 as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Comparable Protective Effects of Low- and High-Dose MK-7 on Bone Structure and Remodeling in a Rat Model of Osteoporosis Induced by Estrogen Deficiency and Glucocorticoid Exposure.Nutrients · 2026 · Chiang HJ, Hsu SY, Leu S, et al.PMID 42197064DOI 10.3390/nu18101605
- Effects of Menaquinone-7 on Bone Turnover Markers, Femoral Mechanical Resistance, and Histology in Young Ovariectomized Rats.Nutrients · 2026 · Jecan A, Tomoaia G, Gherman LM, et al.PMID 42196970DOI 10.3390/nu18101510
- Vitamin K2 (MK7) alleviates arsenic-induced cardiac hypertrophy by suppressing the EGR3/BOK mitochondrial apoptosis pathway.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026 · Liu N, Zhao Q, Xu G, et al.PMID 42097002DOI 10.1016/j.phymed.2026.158262
- Vitamin D3 and K2-loaded keratin nanoparticles inhibit breast cancer cell growth via MCM-7 downregulation and ROS induction.International journal of biological macromolecules · 2026 · Mukherjee S, Bhavya K, Dan S, et al.PMID 42092663DOI 10.1016/j.ijbiomac.2026.152374
- Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK-1/SIR-2.1/DAF-16 Signaling Axis in Caenorhabditis elegans.Aging cell · 2026 · Guo SY, Li YQ, Piao H, et al.PMID 42070156DOI 10.1111/acel.70530
- Dietary vitamin K intakes, chronic obstructive pulmonary disease, adult asthma, and lung function: a prospective cohort study in the UK Biobank.The American journal of clinical nutrition · 2026 · Li C, Pokharel P, Sim M, et al.PMID 42025963DOI 10.1016/j.ajcnut.2026.101324
- The Effects of Vitamin K2 on Recovery from Muscle-Damaging Resistance Exercise in Young and Older Adults: The TAKEOVER Randomized Controlled Trial.Medicine and science in sports and exercise · 2026 · Lithgow H, Johnston L, Ho F, et al.PMID 41843412DOI 10.1249/MSS.0000000000003901
- Colorectal adenoma presence is associated with decreased menaquinone pathway functions in the gut microbiome of patients undergoing routine colonoscopy.PloS one · 2026 · Vilkoite I, Silamiķelis I, Kloviņš J, et al.PMID 41811805DOI 10.1371/journal.pone.0344050
Clinical trials
The 10 most recently updated of 97 ClinicalTrials.gov registrations naming Vitamin K2 as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- The OK Daily StudyNot yet recruiting · Interventional · 134 enrolled · Norfolk and Norwich University Hospitals NHS Foundation TrustNCT07620236updated 2026-06-02
- Effect of vitk2 on Atopic Dermatitis Pediatrics PatientsCompleted · Interventional · 100 enrolled · October 6 UniversityNCT07574242updated 2026-05-07
- Ischemic Stroke Nutrition Intervention StudyActive not recruiting · Interventional · 190 enrolled · Harbin Medical UniversityNCT06817512updated 2026-03-03
- The InterVitaminK Trial - Effects of Vitamin K Supplementation on Cardiovascular, Metabolic, and Bone HealthActive not recruiting · Interventional · 450 enrolled · Bispebjerg HospitalNCT05259046updated 2026-02-17
- The Skin Anti-Aging Effects of Vitamin K2 (MK-7): a Clinical Split-Face/Neck TrialCompleted · Interventional · 36 enrolled · Nanjing Ascend Biotech Technology Co., Ltd.NCT07403942updated 2026-02-11
- The Role of Vitamin K on Knee Osteoarthritis OutcomesRecruiting · Phase 1 · Phase 2 · Interventional · 55 enrolled · Boston UniversityNCT06385275updated 2026-01-23
- Vitamin k, D-chiro Inositol and α-lactalbumin in Bone HomeostasisRecruiting · Observational · 134 enrolled · Regina Elena Cancer InstituteNCT07256769updated 2025-12-01
- Vitamin K2 Supplementation in Adult Episodic MigraineRecruiting · Interventional · 160 enrolled · Sola Aoun Bahous, M.D. Ph.D.NCT05943457updated 2025-11-18
- The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic SyndromeRecruiting · Interventional · 60 enrolled · Ain Shams UniversityNCT07206537updated 2025-10-03
- Evaluating Response to Vitamin D3 and K2 Supplementation in Healthcare PersonnelRecruiting · Interventional · 96 enrolled · Madigan Army Medical CenterNCT07199829updated 2025-09-30
Frequently asked questions
- What is Vitamin K2 used for?
- According to FDA labeling, Vitamin K2 carries indications including: # Suggested areas of application e.g., back of hand, forearm, around knee, back of foot. Avoid using lotions or creams on the application area, as they may hinder absorption.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
Note. Data for
vitamin-k2 is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.