Witch Hazel

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

• Use for relief of minor skin irritations due to: insects bites minor cuts monor scrapes

Directions apply as often as needed

For external use only

ADVERSE REACTION Distributed by Publix Supermarkets, Inc. 3300 Publix Corporate Parkway Lakeland, FL 33811 publix.com

1. 1Drug Ineffective319.8%
2. 2Haemorrhage278.6%
3. 3Rectal Haemorrhage278.6%
4. 4Headache237.3%
5. 5Nausea227.0%
6. 6Diarrhoea216.7%
7. 7Fatigue216.7%
8. 8Pain196.0%
9. 9Condition Aggravated175.4%
10. 10Haemorrhoids175.4%
11. 11Erythema154.8%
12. 12Rash154.8%
13. 13Vomiting154.8%
14. 14Decreased Appetite144.4%
15. 15Dyspnoea144.4%

Recent PubMed references pinned to Witch Hazel as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Comparative Analysis of Polyphenol-Rich Extracts from Hamamelis virginiana Leaves and Bark: ROS Scavenging and Anti-Inflammatory Effects on Skin Cells.
  Molecules (Basel, Switzerland) · 2025 · Wójciak M, Pacuła W, Tyszczuk-Rotko K, et al.
  PMID 40942097DOI 10.3390/molecules30173572
• Metabolomic fingerprint of Hamamelis virginiana L. gallotannins by suspect screening analysis with UHPLC-qToF and their semiquantitative evaluation.
  Journal of mass spectrometry : JMS · 2022 · Burico M, Fodaroni G, Flamini E, et al.
  PMID 36065819DOI 10.1002/jms.4878
• Unveiling the Ability of Witch Hazel (Hamamelis virginiana L.) Bark Extract to Impair Keratinocyte Inflammatory Cascade Typical of Atopic Eczema.
  International journal of molecular sciences · 2022 · Piazza S, Martinelli G, Magnavacca A, et al.
  PMID 36012541DOI 10.3390/ijms23169279
• Phylogenomics AND biogeography of Castanea (chestnut) and Hamamelis (witch-hazel) - Choosing between RAD-seq and Hyb-Seq approaches.
  Molecular phylogenetics and evolution · 2022 · Zhou W, Xiang QJ
  PMID 35926825DOI 10.1016/j.ympev.2022.107592
• The chemical constituents from twigs of Hamamelis japonica and their antiviral activities.
  Natural product research · 2023 · Park S, Nhiem NX, Song JH, et al.
  PMID 35787219DOI 10.1080/14786419.2022.2094376
• A novel family of secreted insect proteins linked to plant gall development.
  Current biology : CB · 2021 · Korgaonkar A, Han C, Lemire AL, et al.
  PMID 33657407DOI 10.1016/j.cub.2021.01.104
• Effect of fragaria vesca, hamamelis and tormentil on the initial bacterial colonization in situ.
  Archives of oral biology · 2020 · Kirsch J, Jung A, Hille K, et al.
  PMID 32801033DOI 10.1016/j.archoralbio.2020.104853
• A seed flying like a bullet: ballistic seed dispersal in Chinese witch-hazel (Hamamelis mollis OLIV., Hamamelidaceae).
  Journal of the Royal Society, Interface · 2019 · Poppinga S, Böse AS, Seidel R, et al.
  PMID 31387485DOI 10.1098/rsif.2019.0327

The 10 most recently updated of 172 ClinicalTrials.gov registrations naming Witch Hazel as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Effects of Cervical Stabilization Exercises With and Without Reverse Natural Apophyseal Glides in Text Neck Syndrome
  Not yet recruiting · Interventional · 42 enrolled · Riphah International University
  NCT07646392updated 2026-06-12
• Neuromuscular Re-education on Pain, ROM and Disability in Cervical Radiculopathy
  Recruiting · Interventional · 52 enrolled · Riphah International University
  NCT07506200updated 2026-06-10
• Effect of Kendall and Scapulothoracic Exercises in Treatment of Chronic Non-specific Neck Pain
  Completed · Interventional · 60 enrolled · Cairo University
  NCT06980337updated 2026-06-09
• Improving Dysphagia in Stroke Patients With Chin Tuck Against Resistance Exercise
  Completed · Interventional · 112 enrolled · Taichung Veterans General Hospital
  NCT07630116updated 2026-06-05
• Effects of CTAR and a Swallowing Pressure Ball in Older Stroke Adults
  Recruiting · Interventional · 132 enrolled · Chimei Medical Center
  NCT07620210updated 2026-06-03
• PPIVMs for Cervicogenic Headache
  Completed · Interventional · 64 enrolled · Jordan University of Science and Technology
  NCT07617051updated 2026-06-01
• Mulligan Mobilization and Stabilization Exercises for Sensorimotor Function in Women With Text Neck Syndrome
  Completed · Interventional · 38 enrolled · Pamukkale University
  NCT07613879updated 2026-05-29
• Mobilization Techniques for Nonspecific Neck Pain: Effects on Cervical Endurance and Function
  Recruiting · Interventional · 51 enrolled · Istanbul University - Cerrahpasa
  NCT07605013updated 2026-05-28
• Effects of Combined Cervical and Oculomotor Exercises on Dynamic Balance in Elderly
  Completed · Interventional · 48 enrolled · Foundation University Islamabad
  NCT07608991updated 2026-05-27
• AI-Driven Programs for Non-specific Chronic Neck Pain
  Active not recruiting · Interventional · 40 enrolled · Cairo University
  NCT07606729updated 2026-05-26

Frequently asked questions

How does Witch Hazel work?

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

What is Witch Hazel used for?

According to FDA labeling, Witch Hazel carries indications including: Use for relief of minor skin irritations due to: insects bites minor cuts monor scrapes. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Witch Hazel?

Witch Hazel is classified as Unknown Cellular or Molecular Interaction, Astringent Activity.

What are the brand names for Witch Hazel?

Witch Hazel is marketed under brand names including A.E.R. Witch Hazel, Tucks.