Zinc Chloride

Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions.

• Zinc Chloride Injection, USP, 1 mg/mL is indicated for use as a supplement to intravenous solutions given for TPN. Administration helps to maintain zinc serum levels and to prevent depletion of endogenous stores, and subsequent deficiency symptoms.

• None known.contraindicated

Zinc Chloride Injection, USP contains 1 mg/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg zinc/day (2.5 to 4 mL/day). An additional 2 mg zinc/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg zinc/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg zinc/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of zinc blood levels is suggested for patients receiving more than the usual maintenance dosage level of zinc. For full term infants and children up to 5 years of age, 100 mcg zinc/kg/day (0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg zinc/kg/day (0.3 mL/kg/day) is suggested. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (See PRECAUTIONS ).

Direct intramuscular or intravenous injection of Zinc Chloride Injection, USP, 1 mg/mL is contraindicated as the acidic pH of the solution (2) may cause considerable tissue irritation. Severe kidney disease may make it necessary to reduce or omit chromium and zinc doses because these elements are primarily eliminated in the urine. WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

None known.

Pregnancy Animal reproduction studies have not been conducted with zinc chloride. It is also not known whether zinc chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Zinc chloride should be given to a pregnant woman only if clearly needed.

Single intravenous doses of 1 to 2 mg zinc/kg body weight have been given to adult leukemic patients without toxic manifestations. However, acute toxicity was reported in an adult when 10 mg zinc was infused over a period of one hour on each of four consecutive days. Profuse sweating, decreased level of consciousness, blurred vision, tachycardia (140/min), and marked hypothermia (94.2° F) on the fourth day were accompanied by a serum zinc concentration of 207 mcg/dl. Symptoms abated within three hours. Hyperamylasemia may be a sign of impending zinc overdosage; patients receiving an inadvertent overdose (25 mg zinc/liter of TPN solution, equivalent to 50 to 70 mg zinc/day) developed hyperamylasemia (557 to 1850 Klein units; normal: 130 to 310). Death resulted from an overdosage in which 1683 mg zinc was delivered intravenously over the course of 60 hours to a 72-year-old patient. Symptoms of zinc toxicity included hypotension (80/40 mm Hg), pulmonary edema, diarrhea, vomiting, jaundice, and oliguria, with a serum zinc level of 4184 mcg/dl. Calcium supplements may confer a protective effect against zinc toxicity.

• Jun 26, 1986NDANDA018959Hospira
• May 21, 2021ANDAANDA212007Exela Pharma
• Oct 16, 2024ANDAANDA216152Somerset

1. 1Fatigue2,55711%
2. 2Pain1,9318.1%
3. 3Nausea1,8897.9%
4. 4Diarrhoea1,8357.7%
5. 5Headache1,8097.5%
6. 6Off Label Use1,7807.4%
7. 7Drug Ineffective1,5316.4%
8. 8Dyspnoea1,4205.9%
9. 9Dizziness1,2915.4%
10. 10Arthralgia1,2865.4%
11. 11Fall1,2315.1%
12. 12Asthenia1,2125.1%
13. 13Constipation1,1134.6%
14. 14Rash1,0594.4%
15. 15Covid-199574.0%

Recent PubMed references pinned to Zinc Chloride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• A randomized controlled clinical evaluation of anti-gingivitis and desensitizing efficacy of a newly developed toothpaste with zinc chloride and oriental herb extract.
  American journal of dentistry · 2026 · Moon KT, Lim JH, Oh K, et al.
  PMID 42247364
• Comparative evaluation of zinc hydroxychloride and zinc sulphate on growth performance, antioxidant status, immune function, and zinc bioavailability in growing crossbred calves.
  Veterinary research communications · 2026 · Pal RP, Mani V, Mir SH, et al.
  PMID 42142145DOI 10.1007/s11259-026-11257-6
• Zinc chloride-catalyzed synthesis of indole-based α-aminophosphonates with potent antimicrobial and anticancer activities: in vitro and in silico evaluation.
  Future medicinal chemistry · 2026 · Aljohani G
  PMID 41988952DOI 10.1080/17568919.2026.2658837
• β-Cyclodextrin-nickel biomacromolecular host system for sustainable ligand-free aqueous CC and CN cross-couplings of aryl chlorides: Toward donor-π-acceptor distyrylbenzene chromophores.
  International journal of biological macromolecules · 2026 · Tukhani M, Hajipour A, Najafi Chermahini A, et al.
  PMID 41765305DOI 10.1016/j.ijbiomac.2026.151111
• ZnCl₂-induced fiber swelling for synergistic manufacturing of adhesive-free straw-chitin biocomposites: Performance and life cycle assessment.
  International journal of biological macromolecules · 2026 · Zhang L, Zuo J, Zhang Z, et al.
  PMID 41692201DOI 10.1016/j.ijbiomac.2026.150929
• Implications of specific ion effects on salt-induced proteome precipitation in organic solvent.
  Analytica chimica acta · 2026 · Dang Z, Nickerson JL, Doucette AA, et al.
  PMID 41644256DOI 10.1016/j.aca.2026.345111
• Anodic Dissolution and Passivation of Zn Electrodes in Electrocoagulation: Effect of Urea Concentration and Chloride-Induced Corrosion.
  Water environment research : a research publication of the Water Environment Federation · 2026 · Atba W, Cherifi M, Moussaoui K, et al.
  PMID 41618074DOI 10.1002/wer.70292
• Addition of Copper Chloride and Zinc Chloride to Liquid-Stored Pig Semen Reduces Bacterial Growth Without Impairing Sperm Quality.
  International journal of molecular sciences · 2026 · Drago J, Bosch-Rué E, Akrim N, et al.
  PMID 41596423DOI 10.3390/ijms27020773

The 10 most recently updated of 46 ClinicalTrials.gov registrations naming Zinc Chloride as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes
  Enrolling by invitation · Phase 4 · Interventional · 10,000 enrolled · Colgate Palmolive
  NCT07619729updated 2026-06-03
• Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash
  Completed · Phase 3 · Interventional · 80 enrolled · Colgate Palmolive
  NCT07263698updated 2026-05-26
• Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.
  Completed · Phase 3 · Interventional · 134 enrolled · Colgate Palmolive
  NCT07398846updated 2026-05-22
• 0.2% Chlorhexidine vs MicroRepair ABX in Gingivitis
  Completed · Interventional · 40 enrolled · University of Pavia
  NCT07088666updated 2026-04-29
• MicroRepair® ABX vs Chlorhexidine 0.12% in Gingivitis Patients
  Completed · Interventional · 40 enrolled · University of Pavia
  NCT07088653updated 2026-04-23
• Prevention of Oral Mucositis in Head and Neck Cancer.
  Recruiting · Interventional · 130 enrolled · Catholic University of the Sacred Heart
  NCT05853692updated 2026-03-19
• Effect of Mouthwash in Reducing the Symptoms Associated With Flu and Cold Viruses
  Completed · Phase 3 · Interventional · 150 enrolled · Colgate Palmolive
  NCT06479226updated 2026-03-18
• A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health
  Completed · Interventional · 175 enrolled · HALEON
  NCT06602466updated 2026-01-22
• A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health
  Completed · Interventional · 154 enrolled · HALEON
  NCT07169188updated 2026-01-21
• Clinical Study to Investigate a New Mouthwash in Reducing Plaque and Helping Prevent Gum Problems on Dental Implants Over a 6-month Period of Product Use
  Completed · Phase 3 · Interventional · 80 enrolled · Colgate Palmolive
  NCT06770114updated 2025-12-01

Frequently asked questions

How does Zinc Chloride work?

Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions.

What is Zinc Chloride used for?

According to FDA labeling, Zinc Chloride carries indications including: Zinc Chloride Injection, USP, 1 mg/mL is indicated for use as a supplement to intravenous solutions given for TPN. Administration helps to maintain zinc serum levels and to prevent depletion of endogenous stores, and subsequent deficiency symptoms.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Zinc Chloride?

Zinc Chloride is classified as Electrolyte solutions, Acid-Base Activity, Electrolyte Activity, Enzyme Interactions, Astringent Activity.

What are the brand names for Zinc Chloride?

Zinc Chloride is marketed under brand names including Bucalsep.

What are the contraindications for Zinc Chloride?

Zinc Chloride labeling lists contraindications including: None known.. Always consult the full prescribing information and a clinician.