Zinc Gluconate
/api/v1/drug/zinc-gluconateMechanism of action
Sourced from openFDAMechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions.
Indications
Sourced from openFDA- Uses reduces the duration of the common cold reduces the severity of cold symptoms: cough, sore throat, nasal congestion, post nasal drip and/or hoarsenessICD-10: J00, R05.9
Dosage & administration
Sourced from openFDADirections • take one lozenge at the onset of symptoms • dissolve entire lozenge in mouth • do not chew • do not swallow whole • do not eat or drink for 15 minutes after use • repeat every 2-4 hours until symptoms subside Adults 18 years and over do not exceed 6 lozenges per day Children 12 to under 18 years do not exceed 4 lozenges per day Children under 12 years ask a doctor before use
Warnings & precautions
Sourced from openFDADo not use for treatment of influenza or allergies. This product is intended only to reduce the duration of the common cold and its symptoms. Ask a doctor or pharmacist before use if you are taking minocycline, doxycycline, tetracycline or are on Coumadin (warfarin) therapy. Zinc treatment may inhibit the absorption of these medicines. When using this product do not take on an empty stomach (to avoid possible minor stomach upset) Stop use and ask your doctor if symptoms persist more than 7 days If pregnant or breastfeeding , ask a healthcare professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
FAERS reports
- 1Fatigue2,70410%
- 2Pain1,9587.6%
- 3Nausea1,9307.5%
- 4Diarrhoea1,9297.5%
- 5Headache1,8507.2%
- 6Off Label Use1,8287.1%
- 7Drug Ineffective1,5566.0%
- 8Dyspnoea1,4935.8%
- 9Arthralgia1,3485.2%
- 10Dizziness1,3415.2%
- 11Asthenia1,2764.9%
- 12Fall1,2654.9%
- 13Constipation1,1254.4%
- 14Rash1,0944.2%
- 15Vomiting1,0103.9%
Literature
Recent PubMed references pinned to Zinc Gluconate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- A Reversal of Heat Stress-Induced Impairments in Boar Endocrine and Reproductive Function by Complex Liposomal Vitamin, Zinc Gluconate, and Betaine Supplementation.Reproduction in domestic animals = Zuchthygiene · 2026 · Ivanickij I, Sharan M, Bartlewski J, et al.PMID 42003767DOI 10.1111/rda.70209
- Orally Administered Zinc Gluconate Induces Tight Junctional Remodeling and Reduces Passive Transmucosal Permeability Across Human Intestine in a Patient-Based Study.International journal of molecular sciences · 2025 · Del Rio EA, Valenzano MC, DiGuilio KM, et al.PMID 40943460DOI 10.3390/ijms26178540
- Characterization of nerve biopsy in copper deficiency peripheral neuropathy due to over-treatment of Wilson's disease: A case report.Acta neurologica Belgica · 2025 · Peng C, Li W, Jiang H, et al.PMID 40087235DOI 10.1007/s13760-025-02762-7
- Minimum inhibitory and bactericidal/fungicidal concentration of commercially available products containing essential oils, zinc gluconate, or 4% chlorhexidine for Malassezia pachydermatis, Pseudomonas aeruginosa, and multi-drug resistant Staphylococcus pseudintermedius canine clinical isolates.Veterinary research communications · 2024 · Bergen A, Roemhild S, Santoro D, et al.PMID 39225973DOI 10.1007/s11259-024-10528-4
- "The effects of non-surgical periodontal treatment plus zinc and magnesium supplementation on oxidative stress and antioxidants enzymes in type 2 diabetes patients: a quasi-experimental study".BMC oral health · 2024 · Alarcón-Moreno JC, Flores-Muñoz M, Blázquez-Morales MSL, et al.PMID 39098894DOI 10.1186/s12903-024-04688-7
- Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024 · Wei Y, Zhu X, Lin S, et al.PMID 39018874DOI 10.1016/j.biopha.2024.117129
- Differential Protective Effect of Zinc and Magnesium for the Hepatic and Renal Toxicity Induced by Acetaminophen and Potentiated with Ciprofloxacin in Rats.Medicina (Kaunas, Lithuania) · 2024 · Ciocan Moraru A, Ciubotariu D, Ghiciuc CM, et al.PMID 38674257DOI 10.3390/medicina60040611
- Determination of the median lethal dose of zinc gluconate in mice and safety evaluation.BMC pharmacology & toxicology · 2024 · Wang YC, Yang X, Xiao J, et al.PMID 38317260DOI 10.1186/s40360-024-00736-8
Clinical trials
The 10 most recently updated of 71 ClinicalTrials.gov registrations naming Zinc Gluconate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus LazertinibActive not recruiting · Phase 2 · Interventional · 305 enrolled · Janssen Research & Development, LLCNCT06120140updated 2026-06-05
- Effect of Zinc on Glucose HomeostasisRecruiting · Phase 4 · Interventional · 200 enrolled · University of Maryland, BaltimoreNCT05835037updated 2026-05-05
- Effect of a Dietary Supplement on Hormones Involved in Appetite Regulation in Overweight and Obese AdultsActive not recruiting · Interventional · 40 enrolled · FFoQSI - Austrian Competence Centre for Feed and Food Quality, Safety & InnovationNCT07240246updated 2026-03-30
- Prevention of Oral Mucositis in Head and Neck Cancer.Recruiting · Interventional · 130 enrolled · Catholic University of the Sacred HeartNCT05853692updated 2026-03-19
- Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones TrialRecruiting · Phase 2 · Interventional · 34 enrolled · University of California, San FranciscoNCT06260891updated 2026-03-13
- Antibacterial Mouthwash for Pharyngeal Gonorrhea PreventionCompleted · Phase 2 · Interventional · 89 enrolled · University of California, Los AngelesNCT04966507updated 2026-02-13
- Evaluation the Efficacy of Zinc on Botulinum Toxin A InjectionNot yet recruiting · Interventional · 20 enrolled · Tishreen UniversityNCT07270042updated 2025-12-08
- ZINCLO-HAND: Zinc and Clobetasol for the Prevention of Regorafenib-Induced Hand-Foot Skin ReactionCompleted · Interventional · 150 enrolled · Gazi UniversityNCT06856590updated 2025-09-15
- Zinc Effect on Inflammation and Cardiovascular Risk in HIVCompleted · Early phase 1 · Interventional · 95 enrolled · University Hospitals Cleveland Medical CenterNCT05085834updated 2025-06-12
- Zinc Supplementation Prior to Botox Injections for Spasmodic DysphoniaActive not recruiting · Phase 1 · Phase 2 · Interventional · 36 enrolled · University of FloridaNCT05892770updated 2025-02-25
Frequently asked questions
- How does Zinc Gluconate work?
- Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions.
- What is Zinc Gluconate used for?
- According to FDA labeling, Zinc Gluconate carries indications including: Uses reduces the duration of the common cold reduces the severity of cold symptoms: cough, sore throat, nasal congestion, post nasal drip and/or hoarseness. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Zinc Gluconate?
- Zinc Gluconate is classified as Zinc, Acid-Base Activity, Electrolyte Activity, Enzyme Interactions.
zinc-gluconate is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.