Zinc Oxide

Mechanism-of-action class: Physiochemical Activity.

• Helps prevent diaper rash. Protects chafed irritated skin due to diaper rash.

Change wet and soiled diapers promptly, cleanser the diaper area, and allow to dry. Push on the bottom to release the product. Heat the product for a few seconds on your hands and apply on baby's bottom. Apply product liberally as often as necessary, with each diaper change, especially at bedtime or anytime when exposure to wet diapers may be prolonged. If necessary, after use, wipe off the excess on the tube contour before closing it.

Allergens: almond For external use only. When using this product avoid contact with eyes. If contact occurs, rinse thoroughly with water. Stop use and consult a doctor if symptoms worsen or last for more than 7 days. Keep out of reach of children. If swallowed, call a poison control centre or get edical help right away.

• Feb 16, 2006NDANDA021026Mylan

1. 1Drug Ineffective59619%
2. 2Macular Degeneration45315%
3. 3Off Label Use36712%
4. 4Nausea35911%
5. 5Pyrexia34711%
6. 6Pain34511%
7. 7Malaise2879.2%
8. 8Weight Decreased2829.0%
9. 9Constipation2548.1%
10. 10Headache2498.0%
11. 11Diarrhoea2477.9%
12. 12Abdominal Pain2267.2%
13. 13Therapeutic Product Effect Incomplete2166.9%
14. 14Anaemia2066.6%
15. 15Dyspepsia2066.6%

Recent PubMed references pinned to Zinc Oxide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• One-pot fabrication and characterization of ZnO nanoflowers using Zanthoxylum simulans and evaluating their biomedical claims.
  Mikrochimica acta · 2026 · Rajan DK, Rajan DK, Li H, et al.
  PMID 42246990DOI 10.1007/s00604-026-08166-5
• Folding integrated all-paper photoelectrochemical immunoassay using annealed ZnO for point-of-care detection of ferritin.
  Analytica chimica acta · 2026 · Cai Y, Li H, Chen Y, et al.
  PMID 42242821DOI 10.1016/j.aca.2026.345704
• The effects of platelet rich plasma and zinc oxide nanoparticle on skin wound healing in dogs.
  Scientific reports · 2026 · Wafy MN, Hassan EA, Saeed S, et al.
  PMID 42230869DOI 10.1038/s41598-026-54633-7
• Green synthesis of ZnO nanoparticles from Cocos nucifera spadix: A sustainable route toward antimicrobial and anti-biofilm applications.
  Journal of microbiological methods · 2026 · Karthik K, Mehar AK, Nath JK, et al.
  PMID 42203007DOI 10.1016/j.mimet.2026.107558
• Simultaneous Enhancement of Mildew Resistance and Dimensional Stability of Bamboo with a Facile One-Step In Situ Growth of ZnO/TA/Ag Composites.
  Molecules (Basel, Switzerland) · 2026 · Xu J, Ma J, Liu L, et al.
  PMID 42197291DOI 10.3390/molecules31101737
• Construction of hierarchically porous ZnO@ZIF-8 for enrichment and sensitive detection of bisphenols in environmental matrices.
  Journal of chromatography. A · 2026 · Liu Z, Li D, Ren M, et al.
  PMID 42177851DOI 10.1016/j.chroma.2026.467122
• Cashew gum-assisted polylactic acid/polypyrrole nanocomposite films loaded with zinc oxide nanoparticles: A sustainable route toward high-performance biohybrids.
  International journal of biological macromolecules · 2026 · Kalladi AJ, Ramesan MT
  PMID 42176925DOI 10.1016/j.ijbiomac.2026.152663
• In Vitro Anticancer Activity of Green-Synthesized Zinc Oxide Nanoparticles from Root Extract of Sida schimperiana against MDA-MB-231 Breast Cancer Cell Lines.
  Asian Pacific journal of cancer prevention : APJCP · 2026 · Hagos A, Hagos Z, Tekluu B, et al.
  PMID 42169591DOI 10.31557/APJCP.2026.27.5.1845

The 10 most recently updated of 245 ClinicalTrials.gov registrations naming Zinc Oxide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Breast Milk Versus Barrier Creams for Diaper Dermatitis in Children Aged 0-24 Months
  Not yet recruiting · Interventional · 160 enrolled · University of Malaya
  NCT07633808updated 2026-06-11
• Silicone Barrier Spray Versus Zinc Oxide Ointment for Incontinence-Associated Dermatitis
  Completed · Interventional · 40 enrolled · Taoyuan Armed Forces General Hospital
  NCT07637695updated 2026-06-11
• Salvadora Persica-Zinc Oxide Versus MTA as Pulpotomy Agents in Mature Permanent Molars With Irreversible Pulpitis
  Not yet recruiting · Interventional · 78 enrolled · Postgraduate Medical Institute, Lahore
  NCT07630181updated 2026-06-05
• Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
  Recruiting · Observational · 20 enrolled · Spark Biomedical, Inc.
  NCT06487533updated 2026-06-02
• R. Officinalis as Pulpotomy Agent in Permanent Teeth With Irreversible Pulpitis
  Not yet recruiting · Interventional · 100 enrolled · University of Health Sciences Lahore
  NCT07610057updated 2026-05-27
• Darbe Plus IV Iron to Decrease Transfusions While Maintaining Iron Sufficiency in Preterm Infants
  Recruiting · Phase 2 · Interventional · 120 enrolled · University of Washington
  NCT05340465updated 2026-05-26
• Effects of Low-Dye Taping Compared to Calcaneal Taping in Patients With Plantar Fasciitis
  Recruiting · Interventional · 40 enrolled · Foundation University Islamabad
  NCT07544732updated 2026-05-20
• Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial
  Not yet recruiting · Early phase 1 · Interventional · 110 enrolled · University of Sao Paulo
  NCT07542639updated 2026-05-12
• Endodontic Post-operative Pain Evaluation of Patients After Using Endomethasone N or Endomethasone SP (EndoPOP)
  Completed · Interventional · 300 enrolled · Septodont
  NCT04885686updated 2026-05-06
• Effect of Zinc Oxide Ointment on Recurrent Aphthous Stomatitis
  Completed · Phase 4 · Interventional · 100 enrolled · Faculty of Dental Medicine for Girls
  NCT07565181updated 2026-05-04

Frequently asked questions

How does Zinc Oxide work?

Mechanism-of-action class: Physiochemical Activity.

What is Zinc Oxide used for?

According to FDA labeling, Zinc Oxide carries indications including: Helps prevent diaper rash. Protects chafed irritated skin due to diaper rash.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Zinc Oxide?

Zinc Oxide is classified as Physiochemical Activity, Sunscreening Activity.

What are the brand names for Zinc Oxide?

Zinc Oxide is marketed under brand names including A+D Diaper Rash, Aquaphor Diaper Rash, Baby Anti Monkey Butt Diaper Rash Cream, Baby Butz Diaper Rash, Balmex, Baza-Protect, Baza-Protect Reformulated June 2020, Booty Goo.