Sciatica

DefinitionNLM MeSH D012585

A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.

Source: U.S. National Library of Medicine — MeSH (Sciatica)

Drugs reporting Sciatica (3)

Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.

1. 1Allylthiourea125%
2. 2Piroxicam75712%
3. 3Meprobamate383.0%

Related reactions

Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.

• Condition Aggravated2 shared · 0.00
• Arthralgia2 shared · 0.00
• Pain2 shared · 0.00
• Dyspnoea2 shared · 0.00
• Drug Ineffective2 shared · 0.00

Literature

Recent PubMed references pinned to Sciatica as a MeSH major topic. About the reaction term itself — not about any specific drug.

• Evaluation of large language models with clinical guidance for vetting outpatient magnetic resonance imaging lumbar spine referrals.
  Scottish medical journal · 2026 · Clackett W, Alsusa H, Watson H, et al.
  PMID 41989203DOI 10.1177/00369330261441582
• [Effect of body mass index on the efficacy of acupuncture for discogenic sciatica: a secondary analysis of a multicenter randomized controlled trial].
  Zhongguo zhen jiu = Chinese acupuncture & moxibustion · 2026 · Zhang D, Shi G, Yan S, et al.
  PMID 41987443DOI 10.13703/j.0255-2930.20250402-0001
• Influence of ginger root extract supplementation on the microbiota-gut-brain axis in individuals with sciatica: Study protocol for a double-blind, placebo-controlled randomized trial.
  Clinical nutrition ESPEN · 2026 · Shen CL, Elmassry MM, Kahathuduwa C, et al.
  PMID 41831719DOI 10.1016/j.clnesp.2026.103117
• Radiologic and pathologic evaluation for a large schwannoma of the sciatic nerve: A neglected cause of sciatica.
  Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology · 2026 · Doğan Y, Aksakal MF, Yeni Yıldırım S, et al.
  PMID 41609324DOI 10.14744/agri.2024.89577
• A Novel Approach: Ultrasound-Guided Transgluteal Sciatic Nerve Block Using D5W and Bupivacaine/Dexamethasone for Acute Sciatica in the Emergency Department.
  The Journal of emergency medicine · 2026 · Stenberg R, Ceraolo N, Ritz A, et al.
  PMID 41529364DOI 10.1016/j.jemermed.2025.11.012
• Utilizing an ultrasound-guided nerve block for management of sciatica in the ED: A national simulation-based cost savings analysis.
  The American journal of emergency medicine · 2026 · Driver L, Walsh CD, Schissel C, et al.
  PMID 41512443DOI 10.1016/j.ajem.2025.12.045