Ammonium Chloride
AcidifiersElectrolyte solutionsAcid-Base ActivityGeneralized Systemic EffectsUS-FDASourced from openFDA
GET
/api/v1/drug/ammonium-chlorideMechanism of action
Sourced from openFDAMechanism-of-action class: Acid-Base Activity.
Indications
Sourced from openFDA- Low back pain and constipation*ICD-10: K59.00
Dosage & administration
Sourced from openFDAAdults and children: At the onset of symptoms, dissolve 5 pellets under the tongue 3 times a day until symptoms are relieved or as directed by a doctor.
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
236 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Off Label Use11448%
- 2Condition Aggravated10444%
- 3General Physical Health Deterioration10243%
- 4Somnolence10042%
- 5Sepsis9741%
- 6Multiple Organ Dysfunction Syndrome9641%
- 7Stress9641%
- 8Hyponatraemia9440%
- 9Anaemia9038%
- 10Swelling9038%
- 11Diabetes Mellitus8737%
- 12Neuralgia8536%
- 13Thrombosis8536%
- 14Intentional Product Misuse8436%
- 15Myasthenia Gravis8436%
Literature
Recent PubMed references pinned to Ammonium Chloride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Chronic NH(4)Cl loading improves glucose tolerance without modifying insulin sensitivity in mice.Scientific reports · 2026 · Zaibi N, Montaigne J, Baraka-Vidot J, et al.PMID 41634125DOI 10.1038/s41598-026-38007-7
- Inhibition of HCN Channels Enhances Oxidative Stress and Autophagy of NRK-52E Cells Under NH(4)Cl Treatment.International journal of molecular sciences · 2025 · López-González Z, Escobar LI, León-Aparicio D, et al.PMID 41009789DOI 10.3390/ijms26189227
- Effect of ammonium chloride on the salt-induced cohesive behavior of egg yolk liquid and its plasma with granules.Food chemistry · 2025 · Ye Y, Li H, Wu N, et al.PMID 40752442DOI 10.1016/j.foodchem.2025.145614
- Insights into hydrochar's physicochemical properties evolution and nitrogen migration mechanism during co-hydrothermal carbonization of microalgae and corn stalk with FeCl(3)/NH(4)Cl/melamine addition.Bioresource technology · 2025 · Peng Y, Zhu X, Shen Q, et al.PMID 40318844DOI 10.1016/j.biortech.2025.132612
- A comparative study of kidney lithogenic agents in Wistar rats by invasive and noninvasive methods.Journal of pharmacological and toxicological methods · 2025 · Sakthikarthikeyan S, Ramesh S, Senthilkumar P, et al.PMID 40280206DOI 10.1016/j.vascn.2025.107743
- Ammonium chloride, an environmental pollutant, disrupts melanocyte biology through the regulation of melanosome and autophagy.Ecotoxicology and environmental safety · 2025 · Oh SW, Yu E, Park SH, et al.PMID 40262244DOI 10.1016/j.ecoenv.2025.118214
- Ammonium chloride mitigates the amplification of fish virus by blocking autophagy-dependent replication.Journal of immunology (Baltimore, Md. : 1950) · 2025 · Chen DD, Zhang JX, Li ZC, et al.PMID 40073239DOI 10.1093/jimmun/vkae012
- Factors associated with success rate of oral force-feeding ammonium chloride administration to acidify urine in goats.Open veterinary journal · 2024 · Pongphitcha P, Chuchoed K, Thetsana T, et al.PMID 39553758DOI 10.5455/OVJ.2024.v14.i9.19
Clinical trials
The 10 most recently updated of 99 ClinicalTrials.gov registrations naming Ammonium Chloride as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Efficacy and Safety of "LMW - CL - HA - FACE/BODY" for the Augmentation of the CheeksCompleted · Interventional · 26 enrolled · Rose Pharma SANCT06915402updated 2026-05-29
- Mechanisms of Diuretic Resistance in Heart Failure, Aim 3Recruiting · Phase 1 · Interventional · 50 enrolled · Yale UniversityNCT06209359updated 2026-05-22
- Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral SupportRecruiting · Phase 2 · Phase 3 · Interventional · 129 enrolled · Protara TherapeuticsNCT06910943updated 2026-05-15
- The Effects of Iontophoresed Vasoactive Drugs on Cutaneus Blood FlowTerminated · Interventional · 31 enrolled · University Hospital, LinkoepingNCT04777383updated 2026-05-13
- A Phase II Study of Intravitreal KIO-301 in Patients With Late-stage Retinitis PigmentosaRecruiting · Phase 2 · Interventional · 36 enrolled · Kiora Pharmaceuticals, Inc.NCT06628947updated 2026-04-30
- Dietary Allowance of Methyl Donor Nutrients to Minimize Risks of Non-alcoholic Fatty Liver ProgressionCompleted · Interventional · 51 enrolled · Fu Jen Catholic University HospitalNCT05291104updated 2026-04-14
- Antiplaque Efficacy and Patient Reported Outcome of Chlorohexidine, Cetylpyridinium Chloride, and Essential Oil Mouthwashes in Orthodontic PatientsRecruiting · Interventional · 24 enrolled · University of BaghdadNCT07490873updated 2026-03-24
- Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel ResectionRecruiting · Phase 4 · Interventional · 128 enrolled · University of California, IrvineNCT06112353updated 2026-01-23
- Effectiveness of Ammonium Chloride in Reducing Viral LoadCompleted · Observational · 32 enrolled · National and Kapodistrian University of AthensNCT07254052updated 2025-11-28
- Stimulation With Bethanechol in Combination With Gemcitabine and Nab-paclitaxel in Pancreatic AdenocarcinomaRecruiting · Phase 2 · Interventional · 37 enrolled · Susan E. BatesNCT05241249updated 2025-06-05
Frequently asked questions
- How does Ammonium Chloride work?
- Mechanism-of-action class: Acid-Base Activity.
- What is Ammonium Chloride used for?
- According to FDA labeling, Ammonium Chloride carries indications including: Low back pain and constipation*. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Ammonium Chloride?
- Ammonium Chloride is classified as Acidifiers, Electrolyte solutions, Acid-Base Activity, Generalized Systemic Effects.
Note. Data for
ammonium-chloride is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.