Somnolence

DefinitionNLM MeSH D000077260

Compelling urge to sleep.

Source: U.S. National Library of Medicine — MeSH (Sleepiness)

Drugs reporting Somnolence (239)

Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.

1. 1Indigo1100%
2. 2Policresulen1100%
3. 3Proteus Inconstans1100%
4. 4Proteus Rettgeri1100%
5. 5Escherichia Coli18749%
6. 6Ammonium Chloride10042%
7. 7Zuranolone44233%
8. 8Moxidectin133%
9. 9Tellurium133%
10. 10Tetrahydrozoline8325%
11. 11Elinzanetant2122%
12. 12Trimethobenzamide22816%
13. 13Bismuth Subgallate715%
14. 14Metyrosine1114%
15. 15Amber114%
16. 16Titanium5112%
17. 17Natamycin4211%
18. 18Benzgalantamine511%
19. 19Stiripentol22011%
20. 20Sodium Citrate14811%
21. 21Dextran 70110%
22. 22Cenobamate7969.9%
23. 23Valbenazine2,4309.9%
24. 24Fenfluramine4129.5%
25. 25Lasmiditan1079.5%
26. 26Lofexidine159.4%
27. 27Difelikefalin369.3%
28. 28Levocetirizine2,1299.1%
29. 29Pitolisant1808.9%
30. 30Potassium Chlorate788.9%
31. 31Apomorphine1498.9%
32. 32Flurazepam348.9%
33. 33Albendazole1618.7%
34. 34Acetohydroxamic Acid48.5%
35. 35Flibanserin1678.4%
36. 36Amyl Nitrite58.3%
37. 37Xylometazoline438.1%
38. 38Sodium Ferric Gluconate Complex1698.0%
39. 39Clobazam1,8787.9%
40. 40Viloxazine777.8%
41. 41Ganaxolone487.7%
42. 42Potassium Bromide647.6%
43. 43Doxylamine5677.4%
44. 44Methsuximide137.3%
45. 45Adenine47.1%
46. 46Pimozide337.1%
47. 47Tasimelteon4087.1%
48. 48Rufinamide1787.0%
49. 49Daridorexant1687.0%
50. 50Perampanel5006.8%
51. 51Clorazepate1286.8%
52. 52Dipotassium1286.8%
53. 53Pyridoxine3146.7%
54. 54Apraclonidine76.6%
55. 55Loxapine2396.5%
56. 56Solriamfetol2346.3%
57. 57Ethosuximide1546.3%
58. 58Felbamate1086.2%
59. 59Tetrabenazine4516.2%
60. 60Guanfacine4586.0%
61. 61Oxybate3,9356.0%
62. 62Lumateperone3726.0%
63. 63Pentoxifylline2505.9%
64. 64Eslicarbazepine1875.9%
65. 65Trimipramine835.7%
66. 66Ramelteon4155.7%
67. 67Suvorexant7295.7%
68. 68Cannabidiol1,2685.6%
69. 69Allantoin1805.5%
70. 70Amoxapine265.5%
71. 71Nilutamide45.5%
72. 72Atomoxetine1,4505.5%
73. 73Safinamide675.3%
74. 74Armodafinil1,0965.3%
75. 75Lemborexant1355.2%
76. 76Lurasidone1,0725.2%
77. 77Almotriptan495.1%
78. 78Flumazenil425.0%
79. 79Quazepam155.0%
80. 80Fluvoxamine1144.9%
81. 81Valproate9774.9%
82. 82Deutetrabenazine3184.7%
83. 83Ammonium1504.7%
84. 84Entacapone2114.7%
85. 85Zonisamide6664.6%
86. 86Rasagiline4984.6%
87. 87Clomipramine2044.6%
88. 88Amisulpride2684.5%
89. 89Oxcarbazepine1,4344.5%
90. 90Oxazepam9284.5%
91. 91Modafinil1,4034.4%
92. 92Pregabalin11,6964.4%
93. 93Quetiapine8,1564.3%
94. 94Carbidopa2,1894.2%
95. 95Dextroamphetamine1,9974.2%
96. 96Aspartate1,7184.2%
97. 97Saccharate1,7184.2%
98. 98Diazepam4,9764.2%
99. 99Protriptyline44.2%
100. 100Dobutamine1994.1%
101. 101Ziprasidone8244.1%
102. 102Vitamin A2894.1%
103. 103Valproic Acid1,2644.1%
104. 104Estazolam784.1%
105. 105Levodopa2,3704.0%
106. 106Lacosamide1,4524.0%
107. 107Lanthanum Carbonate2014.0%
108. 108Lanthanum2014.0%
109. 109Chlorzoxazone514.0%
110. 110Vigabatrin5684.0%
111. 111Opicapone844.0%
112. 112Ziconotide953.9%
113. 113Fluvastatin2883.9%
114. 114Primidone3833.8%
115. 115Amphetamine1,8893.8%
116. 116Carbinoxamine73.8%
117. 117Tolcapone133.8%
118. 118Olanzapine4,0543.8%
119. 119Asenapine3253.8%
120. 120Citric Acid853.7%
121. 121Glycerol Phenylbutyrate493.7%
122. 122Trihexyphenidyl353.7%
123. 123Donepezil1,3533.7%
124. 124Lithium Carbonate6403.7%
125. 125Sodium Nitrite23.7%
126. 126Amantadine7333.7%
127. 127Lithium1,5453.7%
128. 128Orphenadrine273.7%
129. 129Suzetrigine353.7%
130. 130Tiagabine33.7%
131. 131Phenelzine573.7%
132. 132Clonazepam5,6783.6%
133. 133Carbamazepine2,3703.6%
134. 134Rivastigmine6723.6%
135. 135Melatonin1,8933.6%
136. 136Eszopiclone8863.5%
137. 137Naphazoline793.5%
138. 138Pramipexole6693.5%
139. 139Samidorphan523.5%
140. 140Ropinirole6263.4%
141. 141Lamotrigine4,4263.4%
142. 142Mirtazapine3,0413.4%
143. 143Haloperidol9073.4%
144. 144Iloperidone473.4%
145. 145Memantine4643.4%
146. 146Chlorpromazine2343.3%
147. 147Oxalate2,4763.3%
148. 148Risperidone4,3633.3%
149. 149Selegiline1153.3%
150. 150Triazolam2803.3%
151. 151Disulfiram363.3%
152. 152Rotigotine4583.3%
153. 153Pimavanserin1,6733.2%
154. 154Levocarnitine1123.2%
155. 155Baclofen2,7793.2%
156. 156Phenylbutyrate533.2%
157. 157Lisdexamfetamine1,0743.2%
158. 158Ethynodiol53.2%
159. 159Carnitine203.2%
160. 160Tizanidine1,2693.1%
161. 161Bismuth Subcitrate343.1%
162. 162Levetiracetam4,0723.1%
163. 163Bromocriptine203.1%
164. 164Paroxetine2,8073.1%
165. 165Brinzolamide3843.1%
166. 166Phenobarbital4763.1%
167. 167Choline103.1%
168. 168Lorazepam5,3813.0%
169. 169Doxepin3703.0%
170. 170Venlafaxine3,8523.0%
171. 171Imipramine213.0%
172. 172Duloxetine5,4272.9%
173. 173Zaleplon462.9%
174. 174Topiramate2,8522.9%
175. 175Idecabtagene Vicleucel342.9%
176. 176Vortioxetine4872.9%
177. 177Escitalopram4,0052.9%
178. 178Alprazolam5,9302.9%
179. 179Peppermint Oil312.9%
180. 180Aripiprazole3,6012.9%
181. 181Fexofenadine6812.9%
182. 182Desvenlafaxine7682.9%
183. 183Vilazodone2622.9%
184. 184Mitotane502.9%
185. 185Vimseltinib122.9%
186. 186Loratadine3,2052.8%
187. 187Fesoterodine3042.8%
188. 188Methadone1,2902.8%
189. 189Tamsulosin5752.8%
190. 190Hydroxocobalamin1132.8%
191. 191Zolpidem3,7312.8%
192. 192Propranolol1,9452.8%
193. 193Dexmethylphenidate1332.7%
194. 194Quinidine1042.7%
195. 195Benztropine1952.7%
196. 196Phenytoin1,0952.7%
197. 197Fluoxetine3,5272.7%
198. 198Gabapentin9,7622.7%
199. 199Methylphenidate1,9672.7%
200. 200Alcaftadine242.7%
201. 201Cariprazine2392.7%
202. 202Ubrogepant1512.7%
203. 203Trazodone4102.7%
204. 204Patisiran722.6%
205. 205Dextromethorphan1,4722.6%
206. 206Brexpiprazole4092.5%
207. 207Flurbiprofen392.5%
208. 208Vorasidenib112.5%
209. 209Ponesimod82.5%
210. 210Eletriptan1732.5%
211. 211Sertraline5,3072.5%
212. 212Acetazolamide1422.4%
213. 213Serdexmethylphenidate172.4%
214. 214Citalopram3,2242.4%
215. 215Desloratadine2452.3%
216. 216Xanomeline402.3%
217. 217Istradefylline1342.3%
218. 218Rimegepant2792.3%
219. 219Nalbuphine52.3%
220. 220Butorphanol72.2%
221. 221Atogepant1322.2%
222. 222Calcifediol482.1%
223. 223Inebilizumab112.1%
224. 224Fentanyl2,3632.1%
225. 225Sumatriptan9452.1%
226. 226Trospium812.1%
227. 227Midazolam5892.1%
228. 228Naltrexone8112.0%
229. 229Polistirex331.9%
230. 230Paliperidone9921.9%
231. 231Droxidopa3931.8%
232. 232Solifenacin4701.8%
233. 233Bupivacaine2821.7%
234. 234Lecanemab501.5%
235. 235Ethanol1171.5%
236. 236Tapentadol3881.2%
237. 237Glecaprevir1171.1%
238. 238Pibrentasvir1171.1%
239. 239Brivaracetam470—

Related reactions

Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.

• Insomnia140 shared · 0.25
• Tremor66 shared · 0.23
• Anxiety124 shared · 0.20
• Confusional State63 shared · 0.19
• Depression94 shared · 0.18
• Drug Interaction86 shared · 0.18
• Feeling Abnormal76 shared · 0.17
• Fall144 shared · 0.17
• Toxicity To Various Agents57 shared · 0.17
• Condition Aggravated118 shared · 0.17

Literature

Recent PubMed references pinned to Sleepiness as a MeSH major topic. About the reaction term itself — not about any specific drug.

• Covid-19 pandemic and fatal sleepiness-related motor vehicle accidents in Finland.
  Sleep medicine · 2026 · Karvonen M, Partinen M, Koivisto A, et al.
  PMID 42035555DOI 10.1016/j.sleep.2026.108972
• Daily associations of subjective and objective sleep parameters with restorative sleep and morning sleepiness in Japanese working adults.
  Scientific reports · 2026 · Kawai K, Iwamoto K, Miyata S, et al.
  PMID 41904205DOI 10.1038/s41598-026-43784-2
• Optimising the caffeine nap for counteracting driver sleepiness in CPAP treated obstructive sleep apnoea patients.
  Scientific reports · 2026 · Filtness AJ, Miller KA, Maynard S, et al.
  PMID 41865160DOI 10.1038/s41598-026-42894-1
• Effects of 5-Minute Light-Intensity Physical Activity Breaks (Sit-Cycling and Stand-Twisting) on Cognitive Function, Sleepiness, and Back Pain in Physically Inactive University Students: Protocol for a Mixed-Design Laboratory Study.
  JMIR research protocols · 2026 · Ma J, Chua BKT, Chin YHJ, et al.
  PMID 41843905DOI 10.2196/82510
• Sleep quality and sleepiness in adults with multiple myeloma. Is melatonin a potential treatment?
  Physiological reports · 2026 · Fiori M, de Azevedo EM, Rodrigues LS, et al.
  PMID 41814853DOI 10.14814/phy2.70805
• Daytime sleepiness and specific food cravings: The moderating role of insulin sensitivity.
  PloS one · 2026 · Romaker EK, Krueger MJ, Goldfinger MS, et al.
  PMID 41802015DOI 10.1371/journal.pone.0343407