Bismuth Subsalicylate

Mechanism-of-action classes: Acid-Base Activity; Cyclooxygenase Inhibitors.

• Uses relieves travelers’ diarrhea diarrhea upset stomach due to overindulgence in food and drink including: heartburn indigestion nausea gas belching fullnessICD-10: R11.2

Directions chew or dissolve in mouth Adults and children over 12 years : 2 tablets (1 dose) every ½ hour or 4 tablets (2 doses) every hour as needed for diarrhea 2 tablets (1 dose) every 1/2 hour as needed for overindulgence (upset stomach, heartburn, indigestion, nausea) do not exceed 8 doses (16 tablets) in 24 hours use until diarrhea stops but no more than 2 days Children under 12 years of age: ask a doctor drink plenty of clear fluids to prevent dehydration caused by diarrhea

Reye’s syndrome Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert Contains salicylate. Do not take if you are allergic to salicylates (including aspirin) taking other salicylate products Do not use if you have an ulcer a bleeding problem bloody or black stool Ask a doctor before use if you have fever mucus in the stool Ask a doctor or pharmacist before use if you are taking any drug for anticoagulation (thinning the blood) diabetes gout arthritis Stop use and ask a doctor if symptoms get worse or last more than 2 days ringing in the ears or loss of hearing occurs n diarrhea lasts more than 2 days When using this product a temporary, but harmless, darkening of the stool and/or tongue may occur If pregnant or breast-feeding ask a health professional before use.

1. 1Chronic Kidney Disease1,41825%
2. 2Acute Kidney Injury82214%
3. 3Diarrhoea73313%
4. 4Renal Failure72513%
5. 5Nausea63611%
6. 6End Stage Renal Disease4638.1%
7. 7Vomiting4177.3%
8. 8Fatigue3766.6%
9. 9Renal Injury3275.7%
10. 10Gastrooesophageal Reflux Disease3125.5%
11. 11Drug Ineffective2925.1%
12. 12Depression2814.9%
13. 13Constipation2674.7%
14. 14Pain2624.6%
15. 15Off Label Use2594.6%

The 10 most recently updated of 63 ClinicalTrials.gov registrations naming Bismuth Subsalicylate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea
  Terminated · Phase 3 · Interventional · 482 enrolled · Centers for Disease Control and Prevention
  NCT03535272updated 2026-05-22
• Levofloxacin-Based Sequential Therapy Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication
  Not yet recruiting · Interventional · 90 enrolled · University of Health Sciences Lahore
  NCT07574983updated 2026-05-08
• Measuring AI Reliance Among Intern Doctors in Palestine
  Enrolling by invitation · Interventional · 159 enrolled · Al-Quds University
  NCT07558746updated 2026-04-30
• Personalized vs Standard of Care Treatment for Helicobacter Pylori Eradication Among Veterans
  Not yet recruiting · Phase 3 · Interventional · 360 enrolled · VA Office of Research and Development
  NCT07104318updated 2026-04-07
• Effect of Bismuth Subsalicylate on the Gut Microbiome and Host Response in Healthy Adults
  Completed · Phase 1 · Interventional · 34 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT05930197updated 2026-03-24
• Prevalence of Asymptomatic H Pylori Infection Among Patients Undergoing PCI and Impact of Its Eradication on Occurrence of GIT Symptoms and Bleeding"
  Completed · Phase 3 · Interventional · 121 enrolled · Beni-Suef University
  NCT07487142updated 2026-03-23
• RELISTOR's Effects on Opioid-Induced Constipation
  Withdrawn · Observational · 0 enrolled · Methodist Health System
  NCT04930237updated 2026-03-23
• Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients
  Recruiting · Phase 2 · Interventional · 180 enrolled · Emory University
  NCT06780202updated 2026-03-09
• Gut Microbiota in Acute Stroke Patients
  Completed · Observational · 120 enrolled · Chinese University of Hong Kong
  NCT03934021updated 2026-02-24
• Controlled Trial of Omadacycline Randomized Treatment Given for Bone and Joint Infection
  Active not recruiting · Phase 2 · Interventional · 180 enrolled · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
  NCT05753215updated 2026-01-14

Frequently asked questions

How does Bismuth Subsalicylate work?

Mechanism-of-action classes: Acid-Base Activity; Cyclooxygenase Inhibitors.

What is Bismuth Subsalicylate used for?

According to FDA labeling, Bismuth Subsalicylate carries indications including: Uses relieves travelers’ diarrhea diarrhea upset stomach due to overindulgence in food and drink including: heartburn indigestion nausea gas belching fullness. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Bismuth Subsalicylate?

Bismuth Subsalicylate is classified as Bismuth, Acid-Base Activity, Cyclooxygenase Inhibitors, Inhibition Gastric Acid Secretion.

What are the brand names for Bismuth Subsalicylate?

Bismuth Subsalicylate is marketed under brand names including Bismarex, Bismusal, Estomaquil, Kaopectate Reformulated Aug 2006, Pepto-bismol, Percy Medicine.