Caffeic Acid

• HOMEOPATHIC INDICATIONS: For temporary relief of sinus congestion, headache, indigestion, joint pains, and dizziness.** **These statements are based upon homeopathic principles. They have not been reviewed by the Food and Drug Administration.ICD-10: R51.9

DIRECTIONS: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age.

Keep out of reach of children. In case of overdose, contact physician or a Poison Control Center right away. If pregnant or breast-feeding, ask a health professional before use. Tamper seal: "Sealed for Your Protection." Do not use if seal is broken or missing.

1. 1Platelet Count Decreased1122%
2. 2Anaemia714%
3. 3Myelosuppression48.2%
4. 4Pneumonia48.2%
5. 5Cholecystitis36.1%
6. 6Covid-1924.1%
7. 7Diarrhoea24.1%
8. 8Drug-induced Liver Injury24.1%
9. 9Enteritis24.1%
10. 10Gastrointestinal Haemorrhage24.1%
11. 11Hepatic Failure24.1%
12. 12Neutrophil Count Decreased24.1%
13. 13Thrombocytopenia24.1%
14. 14White Blood Cell Count Decreased24.1%
15. 15Abdominal Pain12.0%

Recent PubMed references pinned to Caffeic Acid as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• In situ photocrosslinking ROS-adaptive caffeoyl chitosan/boronic acid-grafted gelatin hydrogels for treatment of combined radiation-burn injury.
  Biomaterials advances · 2026 · Fang D, Chen S, Wu C, et al.
  PMID 41655328DOI 10.1016/j.bioadv.2026.214760
• Ultrasensitive electrochemical detection of caffeic acid based on boronic acid-diol recognition.
  Food chemistry · 2026 · Chai R, Guo H, Jia X, et al.
  PMID 41483786DOI 10.1016/j.foodchem.2025.147746
• Cichoric acid-loaded hydroxyapatite nanorods remodel the immune microenvironment to enhance bone regeneration.
  Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026 · Lin X, Liu C, Lei Y, et al.
  PMID 41421279DOI 10.1016/j.phymed.2025.157701
• Effect of combination of polyphenols, polysaccharide, and sodium selenite on bortezomib anti-cancer action.
  International journal of biological macromolecules · 2025 · Rani S, Gupta S, Tejavath KK, et al.
  PMID 39694374DOI 10.1016/j.ijbiomac.2024.138809
• Metabolites profile, DPPH and ABTS scavenging and myoglobin protection ratio of aqueous infusion and methanolic extracts of Mexican Lippia alba.
  Food chemistry · 2025 · Segoviano-León JP, Valdez-Morales M, Leyva-Morales JB, et al.
  PMID 39616763DOI 10.1016/j.foodchem.2024.142259
• Two Novel Fluorescence Probes Based on Caffeic Acid Derivative for Phosphate Ions and Their Applications in Biological Samples.
  International journal of molecular sciences · 2024 · Zhou X, Yang X, Rao X, et al.
  PMID 39519231DOI 10.3390/ijms252111680
• Which Constituents Determine the Antioxidant Activity and Cytotoxicity of Garlic? Role of Organosulfur Compounds and Phenolics.
  International journal of molecular sciences · 2024 · Furdak P, Bartosz G, Sadowska-Bartosz I, et al.
  PMID 39125961DOI 10.3390/ijms25158391
• Ultrarobust stable ABTS radical cation prepared using Spore@Cu-TMA biocomposites for antioxidant capacity assay.
  Talanta · 2024 · Yan H, Hou W, Lei B, et al.
  PMID 38788382DOI 10.1016/j.talanta.2024.126282

The 10 most recently updated of 14 ClinicalTrials.gov registrations naming Caffeic Acid as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• A Comparative Single Blind Clinical Study on the Effect of Alvogyl, Eugenol, and Nigella Sativa (Black Seed Oil) for Alveolar Osteitis.
  Not yet recruiting · Phase 2 · Interventional · 40 enrolled · HITEC-Institute of Medical Sciences
  NCT06823544updated 2025-02-12
• WP1066 in Children With Refractory and Progressive or Recurrent Malignant Brain Tumors
  Completed · Phase 1 · Interventional · 10 enrolled · Emory University
  NCT04334863updated 2023-02-21
• Pulpotomy Versus Pulpectomy in Vital Primary Incisors
  Completed · Interventional · 39 enrolled · National Research Centre, Egypt
  NCT05589025updated 2022-10-21
• The Açaí Berry COVID-19 Anti-Inflammation Trial
  Unknown · Phase 2 · Interventional · 480 enrolled · University Health Network, Toronto
  NCT04404218updated 2022-05-31
• GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC)
  Unknown · Phase 3 · Interventional · 80 enrolled · The First Affiliated Hospital of Henan University of Science and Technology
  NCT04648917updated 2020-12-03
• The Efficacy and Safety of Caffeic Acid for Esophageal Cancer
  Unknown · Phase 3 · Interventional · 300 enrolled · The First Affiliated Hospital of Henan University of Science and Technology
  NCT03070262updated 2020-11-27
• Caffeic Acid Combining High-dose Dexamethasone in Management of ITP
  Completed · Phase 4 · Interventional · 214 enrolled · Shandong University
  NCT02556814updated 2020-03-20
• Influence of the Composition of Temporary Restorative Material in Vital Teeth
  Unknown · Interventional · 25 enrolled · Federal University of Uberlandia
  NCT03437655updated 2018-03-07
• FlaxFx, A Research Study of the Effects of Flaxseed Lignans on Colon Health
  Completed · Interventional · 66 enrolled · Fred Hutchinson Cancer Center
  NCT01619020updated 2017-09-13
• CC100: Phase 1 Multiple-Dose Safety and Tolerability in Subjects With ALS
  Unknown · Phase 1 · Interventional · 21 enrolled · Chemigen, LLC
  NCT03049046updated 2017-08-03

Frequently asked questions

What is Caffeic Acid used for?

According to FDA labeling, Caffeic Acid carries indications including: HOMEOPATHIC INDICATIONS: For temporary relief of sinus congestion, headache, indigestion, joint pains, and dizziness.** **These statements are based upon homeopathic principles. They have not been reviewed by the Food and Drug Administration.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.