Calcium Fluoride
US-FDASourced from openFDA
GET
/api/v1/drug/calcium-fluorideIndications
Sourced from openFDA- Uses For the temporary relief of symptoms associated with cracking of joints and minor joint pain. Directions Tip bottle slightly allowing for tablets to fall into the cap.
Dosage & administration
Sourced from openFDADirections Tip bottle slightly allowing for tablets to fall into the cap. Use cap to drop tablets into mouth and allow them to dissolve under the tongue. Adults and adolescents (12 years and older) Take 1 to 4 tablets, one to four times daily, or as recommended by your healthcare practitioner. Children (under 12 years) Take under the direction of your healthcare practitioner.
Warnings & precautions
Sourced from openFDADo not use if you ever had an allergic reaction to this product or any of its ingredients. Stop use and ask a doctor if symptoms persist or worsen. If pregnant or breastfeeding, ask a healthcare practitioner before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
Overdosage
Sourced from openFDAIn case of overdose, get medical help or contact a Poison Control Center right away.
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
522 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Diarrhoea366.9%
- 2Pain346.5%
- 3Headache305.7%
- 4Fatigue295.6%
- 5Nausea285.4%
- 6Arthralgia265.0%
- 7Dizziness254.8%
- 8Pain In Extremity214.0%
- 9Asthenia203.8%
- 10Dyspnoea183.4%
- 11Fall183.4%
- 12Muscle Spasms183.4%
- 13Abdominal Pain Upper173.3%
- 14Eye Pain173.3%
- 15Gait Disturbance173.3%
Literature
Recent PubMed references pinned to Calcium Fluoride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- One-step vs. two-step deposition of CaF(2) nanoparticles: From the perspective of confined water release and bonding effectiveness improvement.Dental materials : official publication of the Academy of Dental Materials · 2026 · Xu J, Lu Y, Zhang K, et al.PMID 41102104DOI 10.1016/j.dental.2025.10.006
- Dual-Band Emissive CaF₂: Eu(2+), Eu(3+) Nanoparticles and Their Composite Films: Synthesis and Properties.Luminescence : the journal of biological and chemical luminescence · 2025 · Song L, Xue Y, Luo L, et al.PMID 40955823DOI 10.1002/bio.70313
- EFFICACY OF A REMINERALIZATION AGENT CONTAINING AMMONIUM FLUORIDE SOLUTION AND NANO SOL CALCIUM FLUORIDE FOR TREATMENT OF INITIAL BUCCAL CARIES LESIONS: A SPLIT-MOUTH RANDOMIZED CONTROLLED CLINICAL TRIAL.The journal of evidence-based dental practice · 2025 · Gözetici-Çil B, Köymen SS, Taş A, et al.PMID 40335196DOI 10.1016/j.jebdp.2025.102093
- Impacts of fluorite dissolution in semiarid endemic soil and ecotoxic effect estimated in Allium cepa.Environmental geochemistry and health · 2025 · Díaz-Duarte ÁR, Anguiano-Vega GA, Ponce-Peña P, et al.PMID 40299117DOI 10.1007/s10653-025-02492-y
- Effect of calcium and calcium-fluoride phytate as active fillers in dental resin-based composites on chemical and physical properties.Dental materials : official publication of the Academy of Dental Materials · 2025 · Buchwald Z, Domke A, Jakubowski M, et al.PMID 40155227DOI 10.1016/j.dental.2025.03.010
- A molecularly imprinted ratio fluorescence sensor based on metal-enhanced fluorescence of core-shell structure CaF(2)-silver nanoparticle for visual detection of dicamba.Analytical and bioanalytical chemistry · 2025 · Xu J, Wu J, Li S, et al.PMID 39786496DOI 10.1007/s00216-024-05715-w
- Efficient recovery of highly pure CaF(2) from fluorine-containing wastewater using an icy lime solution.Water science and technology : a journal of the International Association on Water Pollution Research · 2024 · Cao S, Li Y, Wu X, et al.PMID 39007305DOI 10.2166/wst.2024.211
- Process Intensification for Enhanced Fluoride Removal and Recovery as Calcium Fluoride Using a Fluidized Bed Reactor.International journal of molecular sciences · 2024 · Sinharoy A, Lee GY, Chung CM, et al.PMID 38731865DOI 10.3390/ijms25094646
Clinical trials
The 10 most recently updated of 139 ClinicalTrials.gov registrations naming Calcium Fluoride as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Effect of Bioactive Restorative Materials on Secondary Caries PreventionCompleted · Interventional · 120 enrolled · Jouf UniversityNCT07619378updated 2026-06-02
- Desensitizing Effect and Tooth Color Change After Using Giomer-based Varnish Versus Bioactive Glass Air Polishing in Treating Cervical Hypersensitive LesionsCompleted · Interventional · 30 enrolled · Cairo UniversityNCT05981625updated 2026-05-28
- Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)Recruiting · Interventional · 164 enrolled · Dr. Joachim EnaxNCT07068204updated 2026-04-13
- Effect of CPP-ACP Associated With NaF or SnF₂ on Post-Bleaching Tooth SensitivityCompleted · Interventional · 64 enrolled · Universidade Federal do ParaNCT07506850updated 2026-04-02
- Clinical Evaluation of an Experimental Remineralization ProductCompleted · Interventional · 43 enrolled · Ivoclar Vivadent AGNCT06166849updated 2026-03-27
- Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed OrthodonticsRecruiting · Interventional · 200 enrolled · Cardenal Herrera UniversityNCT07244991updated 2026-03-27
- Assessment of Alkasite Restorative Material Versus Resin Modified Glass Ionomer in Class V Cavities: A Clinical TrialCompleted · Interventional · 50 enrolled · Cairo UniversityNCT06673888updated 2026-03-19
- Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin HypersensitivityNot yet recruiting · Interventional · 70 enrolled · Cairo UniversityNCT07449169updated 2026-03-04
- Polymeric Nano Calcium Fluoride Varnish, Diode Laser, and Their Combination for Dentin HypersensitivityActive not recruiting · Interventional · 30 enrolled · Faculty of Dental Medicine for GirlsNCT07418788updated 2026-02-18
- Effect of Gluma and Bioactive Glass Desensitizers in Treatment of Dentin Hypersensitivity in Cervical Non-Carious LesionsCompleted · Interventional · 40 enrolled · British University In EgyptNCT07063433updated 2026-02-06
Frequently asked questions
- What is Calcium Fluoride used for?
- According to FDA labeling, Calcium Fluoride carries indications including: Uses For the temporary relief of symptoms associated with cracking of joints and minor joint pain. Directions Tip bottle slightly allowing for tablets to fall into the cap.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
Note. Data for
calcium-fluoride is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.