Calcium Hydroxide

• Pain in the back and heels*

Adults and children: At the onset of symptoms, dissolve 5 pellets under the tongue 3 times a day until symptoms are relieved or as directed by a doctor.

1. 1Eczema Infected421%
2. 2Eczema Nummular421%
3. 3Skin Weeping421%
4. 4Drug Ineffective211%
5. 5Headache211%
6. 6Off Label Use211%
7. 7Product Dose Omission211%
8. 8Acute Kidney Injury15.3%
9. 9Adverse Drug Reaction15.3%
10. 10Anaphylactic Reaction15.3%
11. 11Angioedema15.3%
12. 12Blood Pressure Increased15.3%
13. 13Cardiac Death15.3%
14. 14Cardiac Failure15.3%
15. 15Chemical Burn15.3%

Recent PubMed references pinned to Calcium Hydroxide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Clinical Evaluation of Three Direct Pulp Capping Materials in Caries-Induced Pulpitis of Mature Permanent Teeth: A Randomized Controlled Trial.
  Clinical and experimental dental research · 2026 · Li Y, Zeng K, Chen B, et al.
  PMID 42188992DOI 10.1002/cre2.70367
• Comparative Evaluation of Polymeric and Metal Ultrasonic Tips for the Removal of Calcium Hydroxide From Root Canals.
  Medical science monitor : international medical journal of experimental and clinical research · 2026 · Akay A, Erkan Akay S, Doğan ME, et al.
  PMID 42186206DOI 10.12659/MSM.952774
• Effect of low-level laser therapy versus calcium hydroxide intra-canal medication on postoperative pain and inflammatory mediator reduction in symptomatic apical periodontitis: a randomized clinical trial.
  BMC oral health · 2026 · Otaify RR, Abouelenien SS, Ghoneim AG, et al.
  PMID 42186077DOI 10.1186/s12903-026-08642-7
• The effect of nano chitosan and calcium hydroxide intracanal medications on sealer penetration & bond strength in radicular dentin.
  BMC oral health · 2026 · Nasr M, El-Banna A, Elmesellawy MY, et al.
  PMID 42169026DOI 10.1186/s12903-026-08558-2
• Effect of calcium hydroxide removal protocols on push-out bond strength of hydraulic calcium silicate sealers: an in vitro study.
  PeerJ · 2026 · Sivas Yılmaz Ö, Keskin C, Güven Kömürcü A, et al.
  PMID 42153143DOI 10.7717/peerj.21236
• A Comparative Study of Caerin 1.1/1.9 and Calcium Hydroxide in the Treatment of Apical Periodontitis in Rats.
  International dental journal · 2026 · Qin L, You H, Zhang Z, et al.
  PMID 42019205DOI 10.1016/j.identj.2026.109583
• Cytocompatibility and bioactive potential of Pentaclethra macroloba extract and Ca(OH)2 as intracanal medication.
  Brazilian oral research · 2026 · Gioster-Ramos ML, Maquera-Huacho PM, Leguizamon NDP, et al.
  PMID 41880447DOI 10.1590/1807-3107bor-2026.vol40.008
• Comparison of Nanosurface Evaluation and Antimicrobial Efficacy of Calcium Hydroxide-Coated Stainless Steel and Zirconia Crowns in Pediatric Dentistry: An Atomic Force Microscopic Study.
  The journal of contemporary dental practice · 2026 · Seth S, Ravikumar R
  PMID 41820302DOI 10.5005/jp-journals-10024-4011

The 10 most recently updated of 246 ClinicalTrials.gov registrations naming Calcium Hydroxide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
  Recruiting · Phase 1 · Interventional · 60 enrolled · Ain Shams University
  NCT07641933updated 2026-06-12
• Bacterial Profiles in Primary Apical Periodontitis Using 16S rRNA PCR
  Completed · Interventional · 24 enrolled · Hasanuddin University
  NCT07637305updated 2026-06-09
• The Effect of Different Intracanal Medicaments on Periapical Lesion Healing
  Recruiting · Interventional · 60 enrolled · Mustafa Kemal University
  NCT07237620updated 2026-06-08
• Bacterial Profile Changes During Different Sodium Hypochlorite Irrigation Regimens and Calcium Hydroxide Medicament in Root Canal Treatment
  Completed · Interventional · 24 enrolled · Hasanuddin University
  NCT07623278updated 2026-06-05
• Effect of Bioactive Restorative Materials on Secondary Caries Prevention
  Completed · Interventional · 120 enrolled · Jouf University
  NCT07619378updated 2026-06-02
• Comparison of LSTR and Pulpectomy in Primary Molars of Pediatric Patients (LSTR-PULP)
  Completed · Interventional · 110 enrolled · taymour abuawwad
  NCT07026435updated 2026-05-29
• The Effect of Different Intra-canal Medications on Postoperative Pain
  Recruiting · Early phase 1 · Interventional · 111 enrolled · Cairo University
  NCT07603934updated 2026-05-22
• Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis
  Not yet recruiting · Interventional · 28 enrolled · Future University in Egypt
  NCT07585721updated 2026-05-14
• Effect of a Herbal Intracanal Medication On Postoperative Pain And Flare up Incidence In Non Surgical Root Canal Retreatment
  Not yet recruiting · Interventional · 40 enrolled · Minia University
  NCT07578311updated 2026-05-11
• Modulation of Periapical Inflammation Following Nano-sized Intracanal Medication. A Randomized Controlled Clinical Trial
  Recruiting · Interventional · 63 enrolled · Al-Azhar University
  NCT07571837updated 2026-05-06

Frequently asked questions

What is Calcium Hydroxide used for?

According to FDA labeling, Calcium Hydroxide carries indications including: Pain in the back and heels*. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.