Cholecalciferol

Mechanism-of-action class: Enzyme Interactions.

• PNV-DHA is a multivitamin/multimineral nutritional supplement indicated for use in the dietary management of patients with nutritional deficiencies or are in need of nutritional supplementation.

• This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.contraindicated

Before, during and/or after pregnancy, one softgel daily or as directed by a physician.

Ingestion of more than 3 grams of omega-3 fatty acids (such as DHA) per day has been shown to have potential antithrombotic effects, including an increased bleeding time and International Normalized Ratio (INR). Administration of omega-3 fatty acids should be avoided in patients taking anticoagulants and in those known to have an inherited or acquired predisposition to bleeding.

Allergic sensitization has been reported following both oral and parenteral administration of folic acid.

• Feb 21, 2001NDANDA021265Sandoz Canada Inc
• Apr 7, 2005NDANDA021762Organon Llc
• Apr 9, 2026ANDAANDA210273Apotex
• Apr 9, 2026ANDAANDA210672Apotex

1. 1Femur Fracture1,40744%
2. 2Fall82126%
3. 3Osteoarthritis65421%
4. 4Low Turnover Osteopathy61819%
5. 5Hypertension55918%
6. 6Arthralgia48015%
7. 7Gastrooesophageal Reflux Disease44214%
8. 8Osteoporosis43414%
9. 9Intramedullary Rod Insertion42914%
10. 10Anxiety41413%
11. 11Depression41413%
12. 12Pain In Extremity40313%
13. 13Back Pain40113%
14. 14Stress Fracture31910%
15. 15Hyperlipidaemia3069.6%

Recent PubMed references pinned to Cholecalciferol as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Intravital Monitoring of Psoriasis Treatment Response and Drug Delivery Using Multiphoton Fluorescence Lifetime Imaging.
  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026 · Nguyen L, Mess C, Herberger K, et al.
  PMID 42277626DOI 10.1111/srt.70367
• OPN1SW Modulates UVB-Associated DHCR7 Reduction and Associated 25(OH)D3 and Sterol-Pool Responses in Keratinocytes.
  Experimental dermatology · 2026 · Yang Y, Zeng W, Chen G, et al.
  PMID 42223015DOI 10.1111/exd.70285
• Unveiling the Anti-tumor Actions and Therapeutic Potential of Calcitriol in Colorectal Cancer.
  Anticancer research · 2026 · Rafique A, Koh YS
  PMID 42203331DOI 10.21873/anticanres.18175
• Associations Between Concentrations of Vitamin D3, Vitamin B12, and Folate and the Well-Being of Medical Students.
  Nutrients · 2026 · Cieślikiewicz B, Bieńkowska A, Maksymowicz S, et al.
  PMID 42197019DOI 10.3390/nu18101559
• Targeting dysregulated glycolysis in type 2 diabetic osteoporosis: Identification of a diagnostic gene signature and therapeutic validation of calcifediol.
  Life sciences · 2026 · Li M, Li W, Mai G, et al.
  PMID 42184924DOI 10.1016/j.lfs.2026.124473
• 1,25(OH)₂D₃ mitigates bronchopulmonary dysplasia via modulation of the TXNIP-NLRP3-GSDMD signaling pathway.
  Molecular biology reports · 2026 · Chen D, Lin S, Yang L, et al.
  PMID 42183898DOI 10.1007/s11033-026-12016-1
• Potential modulation of ED-71 in regulating H3K18 histone lactylation to suppress osteoclast differentiation and alleviate postmenopausal osteoporosis.
  Biochemical pharmacology · 2026 · Ji Y, Cao T, Rong X, et al.
  PMID 42167450DOI 10.1016/j.bcp.2026.118088
• High-Dose Vitamin D3 Supplementation During Pregnancy and Test-Based Cognitive Performance at Age 10 Years: A Post Hoc Secondary Analysis of a Randomized Clinical Trial.
  JAMA network open · 2026 · Frederiksen OF, Jepsen JRM, Brustad N, et al.
  PMID 42149595DOI 10.1001/jamanetworkopen.2026.11464

The 10 most recently updated of 3,242 ClinicalTrials.gov registrations naming Cholecalciferol as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Host-Diet-Gut Interaction Post Vegan Diet in Pediatric Autoimmune Hepatitis.
  Recruiting · Interventional · 40 enrolled · Institute of Liver and Biliary Sciences, India
  NCT07118657updated 2026-06-12
• Influence of Dermocorticoids on Bone Mineral Density in Patients With Bullous Pemphigoid
  Completed · Phase 4 · Interventional · 47 enrolled · Centre Hospitalier Universitaire, Amiens
  NCT03926377updated 2026-06-12
• Vitamin D in Diabetic Neuropathy
  Not yet recruiting · Phase 2 · Phase 3 · Interventional · 150 enrolled · Tanta University
  NCT07644520updated 2026-06-12
• Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
  Active not recruiting · Phase 3 · Interventional · 67 enrolled · Calcilytix Therapeutics, Inc., a BridgeBio company
  NCT05680818updated 2026-06-11
• Randomized Trial of Enteral Vitamin D Supplementation in Infants < 28 Weeks Gestational Age or <1000 Grams Birth Weight
  Active not recruiting · Interventional · 60 enrolled · The University of Texas Health Science Center, Houston
  NCT05694689updated 2026-06-11
• Effects of High-Dose Vitamin D on Hormones, Neuromuscular Function, Cognition, and Body Composition in Athletes
  Recruiting · Interventional · 200 enrolled · The Jerzy Kukuczka Academy of Physical Education in Katowice
  NCT07641075updated 2026-06-11
• ViDES Trial (Vitamin D Extra Supplementation)
  Active not recruiting · Interventional · 180 enrolled · The University of Texas Health Science Center, Houston
  NCT05459298updated 2026-06-11
• The Effect of Vitamin D Supplementation on the Anti-inflammatory Response in Periodontal Diseases
  Recruiting · Interventional · 120 enrolled · Recep Tayyip Erdogan University Training and Research Hospital
  NCT07636733updated 2026-06-10
• Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome
  Recruiting · Interventional · 56 enrolled · University of Maryland, Baltimore
  NCT05977179updated 2026-06-10
• The Investigation of Vitamin D and Menstrual Cycles Trial, the inVitD Trial: A Phase II Clinical Trial
  Completed · Phase 2 · Interventional · 57 enrolled · National Institute of Environmental Health Sciences (NIEHS)
  NCT05050916updated 2026-06-09

Frequently asked questions

How does Cholecalciferol work?

Mechanism-of-action class: Enzyme Interactions.

What is Cholecalciferol used for?

According to FDA labeling, Cholecalciferol carries indications including: PNV-DHA is a multivitamin/multimineral nutritional supplement indicated for use in the dietary management of patients with nutritional deficiencies or are in need of nutritional supplementation.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Cholecalciferol?

Cholecalciferol is classified as Vitamin D and analogues, Vitamin D, Enzyme Interactions, Decreased Renal Ca++ Excretion, Stimulation Small Intestine Fluid/Electrolyte Absorption.

What are the brand names for Cholecalciferol?

Cholecalciferol is marketed under brand names including Animi-3 with Vitamin D, Cal-Quick, Calcet, Caltrate Gummy Bites, Caltrate Plus D, D-Vi-Sol, D3 Dots, Decalcitrol.

What are the contraindications for Cholecalciferol?

Cholecalciferol labeling lists contraindications including: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.. Always consult the full prescribing information and a clinician.