Cholesterol
GET
/api/v1/drug/cholesterolMechanism of action
Sourced from openFDAMechanism-of-action class: Biological Macromolecular Activity.
Indications
Sourced from openFDA- RX only*
Dosage & administration
Sourced from openFDAAdults and children: At the onset of symptoms, dissolve 5 pellets under the tongue 3 times a day until symptoms are relieved or as directed by a doctor.
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
1,577 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Drug Ineffective1449.1%
- 2Fatigue1127.1%
- 3Nausea966.1%
- 4Diarrhoea935.9%
- 5Pain795.0%
- 6Headache764.8%
- 7Dyspnoea744.7%
- 8Off Label Use734.6%
- 9Arthralgia674.2%
- 10Dizziness674.2%
- 11Pruritus634.0%
- 12Malaise603.8%
- 13Weight Decreased593.7%
- 14Fall583.7%
- 15Insomnia583.7%
Literature
Recent PubMed references pinned to Cholesterol as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Comparative discriminative performance of triglyceride-glucose derived composite indices and cholesterol-high-density lipoprotein cholesterol-glucose derived composite indices for identifying frailty: A cross-sectional study.Science progress · 2026 · Zhang Z, Lei X, Lin X, et al.PMID 42265931DOI 10.1177/00368504261459771
- Discordance between remnant cholesterol and LDL-C associated with the risk of new-onset cardiometabolic multimorbidity: A prospective cohort study.Medicine · 2026 · Rong L, Fan H, Fang Q, et al.PMID 42260855DOI 10.1097/MD.0000000000049157
- LDL-cholesterol targets and lipid-lowering therapies - a plea to medical schemes and the Council for Medical Schemes.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2026 · Marais AD, Blom DJ, Blackhurst DM, et al.PMID 42246860DOI 10.7196/SAMJ.2026.v116i5.4971
- Assessing the Accuracy of LDL-Cholesterol Estimation Formulas in the Tunisian Population.La Tunisie medicale · 2026 · Zarrouk O, Elfekih H, Mrad S, et al.PMID 42246719DOI 10.62438/tunismed.v104i03.6631
- Peroxisomal ABCD1 deficiency in mice drives Th1 bias through 25-HC-LXR signaling in CD4(+) T cells.Frontiers in immunology · 2026 · Maeda R, Oishi M, Nagamori R, et al.PMID 42245638DOI 10.3389/fimmu.2026.1722647
- Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and osteoporosis in type 2 diabetes with MASLD.Asia Pacific journal of clinical nutrition · 2026 · Li S, Yang Y, Tian G, et al.PMID 42242850DOI 10.6133/apjcn.202606_35(3).0006
- Association Between the Cholesterol-HDL-Glucose (CHG) Index and 90-Day Functional Outcomes in Patients with Acute Ischemic Stroke.Brain and behavior · 2026 · Yuan X, Kong X, Zhao M, et al.PMID 42237485DOI 10.1002/brb3.71505
- HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis.eLife · 2026 · Shen Y, Wang Z, Wang X, et al.PMID 42233258DOI 10.7554/eLife.108108
Clinical trials
The 10 most recently updated of 1,818 ClinicalTrials.gov registrations naming Cholesterol as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and ColchicineActive not recruiting · Phase 4 · Interventional · 200 enrolled · Massachusetts General HospitalNCT05850091updated 2026-06-12
- Impact of Transferrin Saturation Guided Maintenance Treatment on Quality of Life in HFE HaemochromatosisActive not recruiting · Interventional · 239 enrolled · Rennes University HospitalNCT04779593updated 2026-06-12
- Sleep Quality and Biomarkers in Adolescent Girls With Anorexia NervosaNot yet recruiting · Observational · 25 enrolled · University of Split, School of MedicineNCT07644728updated 2026-06-12
- A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)Recruiting · Phase 3 · Interventional · 975 enrolled · Merck Sharp & Dohme LLCNCT07216482updated 2026-06-12
- Statins to Prevent Cancer Associated Blood ClotsRecruiting · Phase 4 · Interventional · 4,000 enrolled · Brigham and Women's HospitalNCT07303816updated 2026-06-12
- Extreme Lipids RepositoryActive not recruiting · Observational · 250 enrolled · University of Texas Southwestern Medical CenterNCT04156997updated 2026-06-11
- A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.Active not recruiting · Phase 3 · Interventional · 14,012 enrolled · Novartis PharmaceuticalsNCT05739383updated 2026-06-11
- Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular DiseaseActive not recruiting · Phase 3 · Interventional · 17,004 enrolled · Novartis PharmaceuticalsNCT05030428updated 2026-06-11
- Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated HypertensionCompleted · Interventional · 180 enrolled · Beth Israel Deaconess Medical CenterNCT05121337updated 2026-06-11
- Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular AtherostenosisActive not recruiting · Phase 3 · Interventional · 1,683 enrolled · University of FloridaNCT05047172updated 2026-06-11
Frequently asked questions
- How does Cholesterol work?
- Mechanism-of-action class: Biological Macromolecular Activity.
- What is Cholesterol used for?
- According to FDA labeling, Cholesterol carries indications including: RX only*. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Cholesterol?
- Cholesterol is classified as Biological Macromolecular Activity, Metabolic Activity Alteration.
Note. Data for
cholesterol is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.