Insomnia
458 drugs365,480 FAERS reportsMedDRA PT
GET
/api/v1/reaction/insomniaReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D007319
Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
Source: U.S. National Library of Medicine — MeSH (Sleep Initiation and Maintenance Disorders)
Drugs reporting Insomnia (458)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Niobium1100%
- 2Tantalum1100%
- 3Escherichia Coli20353%
- 4Triprolidine10738%
- 5Prussian Blue Insoluble125%
- 6Estriol37322%
- 7Mefloquine3321%
- 8Eszopiclone3,89116%
- 9Cobamamide114%
- 10Ferrous Cysteine Glycinate114%
- 11Folate114%
- 12Magnesium Ascorbate114%
- 13Nadh114%
- 14Pyridoxal114%
- 15Tarlatamab114%
- 16Threonate114%
- 17Zinc Ascorbate114%
- 18Nabilone26513%
- 19Niraparib2,83913%
- 20Vanadium613%
- 21Tasimelteon72813%
- 22Nefazodone1512%
- 23Potassium Iodide25412%
- 24Daridorexant29312%
- 25Isocarboxazid811%
- 26Chlorcyclizine311%
- 27Pitolisant21411%
- 28Trifluoperazine129.9%
- 29Viloxazine848.6%
- 30Bacillus Subtilis48.5%
- 31Amcinonide78.3%
- 32Aconite28.3%
- 33Pyrrole238.3%
- 34Pentoxifylline3428.1%
- 35Potassium Gluconate28.0%
- 36Iodoquinol37.9%
- 37Tyramine27.4%
- 38Arimoclomol37.3%
- 39Tranylcypromine817.3%
- 40Elbasvir3087.3%
- 41Grazoprevir3087.3%
- 42Flibanserin1427.2%
- 43Intrinsic Factor77.1%
- 44Adenine47.1%
- 45Magnesium Citrate4087.0%
- 46Calcium Citrate26.9%
- 47Nilutamide56.8%
- 48Varenicline5,6156.8%
- 49Fenbendazole66.7%
- 50Vilazodone6136.7%
- 51Phenelzine1046.7%
- 52Taletrectinib36.4%
- 53Lofexidine106.3%
- 54Atomoxetine1,5896.0%
- 55Iloperidone836.0%
- 56Manganese Chloride165.9%
- 57Desvenlafaxine1,5625.9%
- 58Selegiline2045.9%
- 59Chromic Chloride485.7%
- 60Peginterferon Alfa-2a3,0785.7%
- 61Vortioxetine9165.5%
- 62Sacrosidase95.5%
- 63Milnacipran3235.4%
- 64Ramelteon3955.4%
- 65Ribavirin3,4365.4%
- 66Serdexmethylphenidate385.4%
- 67Duloxetine9,7505.3%
- 68Suvorexant6765.3%
- 69Oxyquinoline25.3%
- 70Ammonia55.2%
- 71Oxybate3,3465.1%
- 72Zaleplon805.1%
- 73Levomilnacipran945.0%
- 74Doxepin6135.0%
- 75Aliskiren2955.0%
- 76Rutin44.9%
- 77Lurasidone1,0124.9%
- 78Quetiapine9,2004.9%
- 79Felodipine5364.8%
- 80Roflumilast3204.8%
- 81Vitamin D334.8%
- 82Zolpidem6,2914.7%
- 83Fluvastatin3534.7%
- 84Flurazepam184.7%
- 85Melatonin2,4874.7%
- 86Samidorphan704.7%
- 87Sofosbuvir2,4364.7%
- 88Dalfampridine3,3054.6%
- 89Armodafinil9674.6%
- 90Dexbrompheniramine114.6%
- 91Amitriptyline7824.6%
- 92Sertaconazole74.5%
- 93Ziprasidone9044.5%
- 94Lisdexamfetamine1,5344.5%
- 95Temazepam1,6804.5%
- 96Clonazepam7,0684.5%
- 97Fezolinetant874.5%
- 98Manganese174.5%
- 99Methyltestosterone234.5%
- 100Deutetrabenazine3034.5%
- 101Trazodone6764.4%
- 102Carisoprodol8304.4%
- 103Ledipasvir8354.4%
- 104Calamine194.3%
- 105Paroxetine3,8734.3%
- 106Lithium Carbonate7384.3%
- 107Fenfluramine1844.3%
- 108Solriamfetol1554.2%
- 109Lanolin194.2%
- 110Ferric Oxide214.2%
- 111Pramipexole7954.1%
- 112Caffeine1,9324.1%
- 113Ibandronate1244.1%
- 114Naltrexone1,6474.1%
- 115Liothyronine3534.1%
- 116Indomethacin5304.1%
- 117Fosaprepitant5494.1%
- 118Dextroamphetamine1,9304.0%
- 119Estazolam774.0%
- 120Vitamin A2804.0%
- 121Aspartate1,6404.0%
- 122Saccharate1,6404.0%
- 123Indole604.0%
- 124Skatole604.0%
- 125Tartaric Acid604.0%
- 126Barium Iodide604.0%
- 127Skim Milk604.0%
- 128Pine Tar604.0%
- 129Metyrosine33.9%
- 130Velpatasvir5393.9%
- 131Hydrofluoric Acid603.9%
- 132Ascorbic Acid1,1043.9%
- 133Lithium1,6273.9%
- 134Almotriptan373.9%
- 135Dichlorphenamide633.9%
- 136Helium23.8%
- 137Istradefylline2253.8%
- 138Iodine3053.8%
- 139Calcium Phosphate803.8%
- 140Tetrabenazine2763.8%
- 141Pitavastatin3813.8%
- 142Ferrosoferric Phosphate793.8%
- 143Entacapone1713.8%
- 144Magnesium Phosphate813.8%
- 145Mercuric Chloride753.8%
- 146Cariprazine3333.7%
- 147Selenium3683.7%
- 148Exemestane7873.7%
- 149Quercetin443.7%
- 150Ferrous Iodide753.7%
- 151Lachesis Muta Venom753.7%
- 152Venlafaxine4,8213.7%
- 153Dexmethylphenidate1803.7%
- 154Doxylamine2813.7%
- 155Cholesterol583.7%
- 156Phentermine4413.7%
- 157Zinc Chloride8793.7%
- 158Quazepam113.7%
- 159Tiagabine33.7%
- 160Clidinium713.6%
- 161Ropinirole6623.6%
- 162Calcium Sulfide763.6%
- 163Carnitine233.6%
- 164Lumateperone2253.6%
- 165Pregabalin9,6473.6%
- 166Chlordiazepoxide743.6%
- 167Corticotropin383.6%
- 168Naloxone1,2903.6%
- 169Zolmitriptan2533.6%
- 170Lorazepam6,3403.6%
- 171Elagolix1543.6%
- 172Fluvoxamine843.6%
- 173Modafinil1,1423.6%
- 174Phenol683.6%
- 175Amantadine7093.6%
- 176Anastrozole1,2813.6%
- 177Amphetamine1,7613.6%
- 178Alprazolam7,2283.6%
- 179Triazolam3053.6%
- 180Influenza A Virus1523.6%
- 181Dexpanthenol1,0803.6%
- 182Guanfacine2703.6%
- 183Riboflavin1,0843.5%
- 184Zuranolone473.5%
- 185Zinc Gluconate9123.5%
- 186Prasterone923.5%
- 187Silver Nitrate263.5%
- 188Niacinamide1,0973.5%
- 189Butalbital4063.5%
- 190Finasteride2,0563.5%
- 191Asenapine3003.5%
- 192Celecoxib4,4943.5%
- 193Progesterone7803.5%
- 194Vitamin E1,0703.5%
- 195Trofinetide2073.5%
- 196Cocaine143.4%
- 197Estrone53.4%
- 198Relugolix8263.4%
- 199Naproxen5,5743.4%
- 200Cocoa Butter63.4%
- 201Ichthammol183.4%
- 202Rasagiline3693.4%
- 203Creosote323.4%
- 204Balsalazide173.4%
- 205Amoxapine163.4%
- 206Taurine443.4%
- 207Suzetrigine323.4%
- 208Sertraline7,1663.3%
- 209Bazedoxifene313.3%
- 210Mitapivat243.3%
- 211Fluoxetine4,3093.3%
- 212Proguanil703.3%
- 213Psyllium3173.3%
- 214Methylphenidate2,4033.3%
- 215Mirtazapine2,9563.3%
- 216Levocetirizine7683.3%
- 217Pantothenic Acid323.3%
- 218Avapritinib3743.3%
- 219Barium813.3%
- 220Carbinoxamine63.3%
- 221Diazepam3,8943.3%
- 222Escitalopram4,4393.2%
- 223Barium Carbonate163.2%
- 224Hekla Lava163.2%
- 225Thiamine1,3813.2%
- 226Calcium Iodide163.2%
- 227Candida Albicans373.2%
- 228Eucalyptol613.2%
- 229Vandetanib573.2%
- 230Tryptophan683.2%
- 231Thiothixene73.2%
- 232Tartrate18,1363.2%
- 233Clorazepate603.2%
- 234Dipotassium603.2%
- 235Rotigotine4473.2%
- 236Aripiprazole3,9283.2%
- 237Apomorphine533.2%
- 238Cimetidine2963.2%
- 239Ropeginterferon Alfa-2b533.2%
- 240Propranolol2,2023.2%
- 241Guaifenesin6,3023.2%
- 242Clomiphene463.1%
- 243Sulfuric Acid163.1%
- 244Lead173.1%
- 245Mexiletine133.1%
- 246Topiramate3,0473.1%
- 247Ipecac483.1%
- 248Halcinonide63.1%
- 249Phenylephrine6,7873.1%
- 250Eucalyptus Oil123.1%
- 251Capsaicin1193.1%
- 252Baclofen2,7163.1%
- 253Imipramine223.1%
- 254Levothyroxine9,5573.1%
- 255Elinzanetant33.1%
- 256Ergocalciferol11,5623.1%
- 257Potassium Dichromate163.1%
- 258Ammonium Bromide153.1%
- 259Ammonium Phosphate153.1%
- 260Amoeba Proteus153.1%
- 261Antipyrine153.1%
- 262Arsenate153.1%
- 263Calcium Arsenate153.1%
- 264Calcium Hexafluorosilicate153.1%
- 265Calcium Hypophosphite153.1%
- 266Claviceps Purpurea Sclerotium153.1%
- 267Crataegus Laevigata Fruit153.1%
- 268Croton Oil153.1%
- 269Cupric Acetate153.1%
- 270Eutrochium Purpureum Root153.1%
- 271Ferrous Arsenate153.1%
- 272Gold Trichloride153.1%
- 273Hexafluorosilicate153.1%
- 274Lead Acetate153.1%
- 275Lead Iodide153.1%
- 276Mercuric Iodide153.1%
- 277Mercuric Oxide153.1%
- 278Mercuric Sulfate153.1%
- 279Mercuric Sulfide153.1%
- 280Molybdenum153.1%
- 281Moschus Moschiferus Musk Sac Resin153.1%
- 282Mycobacterium Tuberculosis153.1%
- 283Oxalic Acid153.1%
- 284Picrate153.1%
- 285Potassium Arsenite153.1%
- 286Quinine Arsenite153.1%
- 287Semecarpus Anacardium Juice153.1%
- 288Sodium Bromide153.1%
- 289Staphylococcus Epidermidis153.1%
- 290Staphylococcus Haemolyticus153.1%
- 291Staphylococcus Simulans153.1%
- 292Strontium Salicylate153.1%
- 293Sumbul153.1%
- 294Uranyl Nitrate153.1%
- 295Uranyl Nitrate Hexahydrate153.1%
- 296Vipera Berus Venom153.1%
- 297Virola Sebifera Resin153.1%
- 298Crotalus Horridus Horridus Venom153.1%
- 299Mercuric Cyanide153.1%
- 300Naja Naja Venom153.1%
- 301Zinc Valerate153.1%
- 302Tizanidine1,2433.1%
- 303Buspirone3263.1%
- 304Streptococcus Pyogenes153.1%
- 305Lemborexant793.1%
- 306Barium Chloride153.1%
- 307Ferric Chloride153.1%
- 308Hydrogen Cyanide153.1%
- 309Sulfur Iodide153.1%
- 310Calcium Fluoride163.1%
- 311Arsenic Triiodide153.1%
- 312Cyanide153.1%
- 313Brexpiprazole4943.1%
- 314Calomel153.1%
- 315Turpentine153.1%
- 316Serotonin143.1%
- 317Tin153.0%
- 318Nirogacestat243.0%
- 319Montelukast5,2053.0%
- 320Antimony Trisulfide153.0%
- 321Ammonium Carbonate153.0%
- 322Antimony Potassium Tartrate243.0%
- 323Potassium Tartrate243.0%
- 324Rilzabrutinib63.0%
- 325Kalmia Latifolia Leaf153.0%
- 326Camphor953.0%
- 327Antimony243.0%
- 328Chloride Hexahydrate153.0%
- 329Carbidopa1,5493.0%
- 330Tinidazole133.0%
- 331Dextromethorphan1,7133.0%
- 332Ziconotide723.0%
- 333Lamotrigine3,8143.0%
- 334Nickel183.0%
- 335Sepia Officinalis Juice152.9%
- 336Kerosene152.9%
- 337Aluminum Oxide152.9%
- 338Mercury152.9%
- 339Hydroxyzine1,4402.9%
- 340Zinc1,1402.9%
- 341Rizatriptan4622.9%
- 342Calcium Sulfate162.9%
- 343Palladium152.9%
- 344Sulfacetamide212.9%
- 345Oxalate2,1442.9%
- 346Loratadine3,2572.9%
- 347Eletriptan2002.9%
- 348Cysteine42.9%
- 349Succinate6,3152.9%
- 350Levodopa1,6672.8%
- 351Ensifentrine322.8%
- 352Tamsulosin5772.8%
- 353Tolnaftate392.8%
- 354Potassium Carbonate262.8%
- 355Donepezil1,0112.8%
- 356Methocarbamol6072.8%
- 357Nitric Acid152.8%
- 358Triamterene3642.8%
- 359Disulfiram302.7%
- 360Silicon292.7%
- 361Silicon Dioxide292.7%
- 362Voxilaprevir292.7%
- 363Chlorpromazine1892.7%
- 364Citalopram3,6222.7%
- 365Trimethobenzamide382.7%
- 366Olanzapine2,8822.7%
- 367Tamoxifen1512.7%
- 368Ibuprofen7,4462.7%
- 369Gabapentin9,5692.7%
- 370Dutasteride5812.7%
- 371Elexacaftor3212.6%
- 372Levacetylleucine52.6%
- 373Potassium Acetate502.6%
- 374Metaxalone872.6%
- 375Fexofenadine6102.6%
- 376Chlorpheniramine1,6792.6%
- 377Niacin3172.6%
- 378Pramoxine932.6%
- 379Methenamine552.6%
- 380Nafarelin72.6%
- 381Pimavanserin1,3552.6%
- 382Rezafungin22.6%
- 383Pirfenidone1,0252.6%
- 384Prazosin1822.5%
- 385Dibasic Potassium Phosphate162.5%
- 386Zonisamide3642.5%
- 387Fenofibrate8672.5%
- 388Hydrochlorothiazide5,1722.5%
- 389Clarithromycin8412.5%
- 390Lasmiditan282.5%
- 391Benztropine1772.5%
- 392Lovastatin6222.5%
- 393Pamabrom92.5%
- 394Estrogens1,7342.5%
- 395Luliconazole42.4%
- 396Oxcarbazepine7662.4%
- 397Tolterodine4692.4%
- 398Cenobamate1932.4%
- 399Norethindrone4282.4%
- 400Naratriptan322.4%
- 401Desloratadine2472.4%
- 402Glycine242.4%
- 403Hydrogen212.3%
- 404Enzalutamide1,3572.3%
- 405Aripiprazole Lauroxil1042.3%
- 406Nicotine1,3912.3%
- 407Apremilast3,3222.3%
- 408Valbenazine5652.3%
- 409Sumatriptan1,0382.3%
- 410Raloxifene3642.3%
- 411Arginine382.3%
- 412Pyrimethamine282.3%
- 413Arsenic Trioxide1142.3%
- 414Cromolyn782.2%
- 415Estetrol52.2%
- 416Maleate3,0962.2%
- 417Arsenic1152.2%
- 418Alfuzosin1242.2%
- 419Cannabidiol4992.2%
- 420Levorphanol82.2%
- 421Butorphanol72.2%
- 422Ospemifene562.2%
- 423Ezetimibe1,8902.2%
- 424Nizatidine322.1%
- 425Beclomethasone2102.1%
- 426Xanomeline372.1%
- 427Nerandomilast122.1%
- 428Quinidine802.1%
- 429Risperidone2,7482.1%
- 430Lysine462.1%
- 431Ferrous Fumarate1502.1%
- 432Trospium822.1%
- 433Sambucus Nigra Flowering Top202.1%
- 434Selenium Sulfide192.1%
- 435Deutivacaftor102.0%
- 436Vanzacaftor102.0%
- 437Tyrosine412.0%
- 438Tezacaftor3552.0%
- 439Palmitate6282.0%
- 440Paliperidone1,0091.9%
- 441Oxymetazoline1461.9%
- 442Tovorafenib51.9%
- 443Ubrogepant1061.9%
- 444Solifenacin4841.9%
- 445Testosterone9611.9%
- 446Glecaprevir2011.8%
- 447Pibrentasvir2011.8%
- 448Atogepant1101.8%
- 449Bremelanotide151.7%
- 450Vigabatrin2341.6%
- 451Nirmatrelvir8671.6%
- 452Apalutamide1811.6%
- 453Medroxyprogesterone8261.6%
- 454Leuprolide1,2261.6%
- 455Magnesium Salicylate131.5%
- 456Polistirex251.5%
- 457Brivaracetam217—
- 458Boron11—
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
Literature
Recent PubMed references pinned to Sleep Initiation and Maintenance Disorders as a MeSH major topic. About the reaction term itself — not about any specific drug.
- Psychobiological Correlates of Perceived Physical Activity Barriers: Insomnia, Chronotype, and Caffeine Consumption.International journal of environmental research and public health · 2026 · Eryücel ME, Akil MPMID 42196760DOI 10.3390/ijerph23050666
- Digital Cognitive Behavioral Therapy for Insomnia Versus Sleep Hygiene Education for Prevention of Perinatal Depression: Protocol for a Randomized Clinical Trial.JMIR research protocols · 2026 · Felder JN, Moran PJ, McClelland B, et al.PMID 42190644DOI 10.2196/90969
- Prevalence and associated factors of insomnia among adults in Anhui Province, China.Frontiers in public health · 2026 · Yan J, Liu Y, Xu X, et al.PMID 42180462DOI 10.3389/fpubh.2026.1794419
- Unraveling sleep dysfunction in progressive supranuclear palsy: a pilot study on the role of periodic limb movements in sleep and insomnia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026 · Tucci R, Urso D, Tamburrino L, et al.PMID 42178448DOI 10.1007/s10072-026-09138-6
- Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation.Metabolomics : Official journal of the Metabolomic Society · 2026 · Fan HY, Hsieh CC, Chen TP, et al.PMID 42177678DOI 10.1007/s11306-026-02450-4
- Could behaviour change interventions be incorporated into cardiac rehabilitation programmes for insomnia and poor sleep quality management? A scoping review.Sleep & breathing = Schlaf & Atmung · 2026 · White E, Atef HPMID 42176203DOI 10.1007/s11325-026-03707-x
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.