Chromic Chloride

• Chromium 4 mcg/mL (Chromic Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for TPN. Administration helps to maintain chromium serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

• None known.contraindicated

Chromium 4 mcg/mL (Chromic Chloride Injection, USP) contains 4 mcg chromium/mL and is administered intravenously only after dilution. The additive should be administered in a volume of fluid not less than 100 mL. For the adult receiving TPN, the suggested additive dosage is 10 to 15 mcg chromium/day (2.5 to 3.75 mL/day). The metabolically stable adult with intestinal fluid loss may require 20 mcg chromium/day (5 mL/day), with frequent monitoring of blood levels as a guideline for subsequent administration. For pediatric patients, the suggested additive dosage is 0.14 to 0.20 mcg/kg/day (0.035 to 0.05 mL/kg/day). Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS .

Direct intramuscular or intravenous injection of Chromium 4 mcg/mL (Chromic Chloride Injection, USP) is contraindicated, as the acidic pH of the solution may cause considerable tissue irritation. Severe kidney disease may make it necessary to reduce or omit chromium and zinc doses because these elements are primarily eliminated in the urine. WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

None known.

Pregnancy Animal reproduction studies have not been conducted with chromic chloride. It is also not known whether chromic chloride can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Chromic chloride should be given to a pregnant woman only if clearly indicated.

Trivalent chromium administered intravenously to TPN patients has been shown to be nontoxic when given at dosage levels of up to 250 mcg/day for two consecutive weeks. Reported toxic reactions to chromium include nausea, vomiting, ulcers of the gastrointestinal tract, renal and hepatic damage, convulsions and coma. The acute LD 50 for intravenous trivalent chromium in rats was reported as 10 to 18 mg/kg.

• Jun 26, 1986NDANDA018961Hospira
• Nov 18, 2024ANDAANDA218538Somerset Theraps Llc

1. 1Fatigue10012%
2. 2Nausea8710%
3. 3Diarrhoea819.7%
4. 4Headache718.5%
5. 5Pain667.9%
6. 6Drug Ineffective627.4%
7. 7Dizziness556.6%
8. 8Asthenia526.2%
9. 9Arthralgia516.1%
10. 10Weight Decreased506.0%
11. 11Insomnia485.7%
12. 12Fall455.4%
13. 13Cough435.1%
14. 14Malaise435.1%
15. 15Vomiting414.9%

Recent PubMed references pinned to Chromic Chloride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Analysis of Density Changes of Selected Brain Receptors After a 14-Day Supply of Chromium(III) and Evaluation of Chromium(III) Affinity to Selected Receptors and Transporters.
  Biological trace element research · 2020 · Piotrowska A, Siwek A, Wolak M, et al.
  PMID 31732929DOI 10.1007/s12011-019-01924-y
• Pharmacokinetics and bioavailability of chromium malate and its influence on trace metals absorption after oral or intravenous administration.
  Indian journal of pharmacology · 2018 · Feng W, Li Q, Wang W, et al.
  PMID 30100655DOI 10.4103/ijp.IJP_505_17
• Interactions between chromium(III) and iron(III), molybdenum(III) or nickel(II): Cytotoxicity, genotoxicity and mutagenicity studies.
  Chemosphere · 2018 · Terpilowska S, Siwicki AK
  PMID 29550572DOI 10.1016/j.chemosphere.2018.03.062
• A Water-Stable Cl@Ag(14) Cluster Based Metal-Organic Open Framework for Dichromate Trapping and Bacterial Inhibition.
  Inorganic chemistry · 2017 · Zhang SS, Wang X, Su HF, et al.
  PMID 28933555DOI 10.1021/acs.inorgchem.7b01879
• Theoretical Insight into the Conversion Mechanism of Glucose to Fructose Catalyzed by CrCl(2) in Imidazolium Chlorine Ionic Liquids.
  The journal of physical chemistry. B · 2017 · Jing Y, Gao J, Liu C, et al.
  PMID 28195725DOI 10.1021/acs.jpcb.6b11820
• Effects of Excess Cr(3+) on Trace Element Contents in the Brain and Serum in Chicken.
  Biological trace element research · 2017 · Liu Y, Hao P, Zhang X, et al.
  PMID 27761845DOI 10.1007/s12011-016-0875-0
• Comparison of chromium III and VI toxicities in water using sulfur-oxidizing bacterial bioassays.
  Chemosphere · 2016 · Qambrani NA, Hwang JH, Oh SE, et al.
  PMID 27393970DOI 10.1016/j.chemosphere.2016.06.090
• Anti-atherogenic effect of trivalent chromium-loaded CPMV nanoparticles in human aortic smooth muscle cells under hyperglycemic conditions in vitro.
  Nanoscale · 2016 · Ganguly R, Wen AM, Myer AB, et al.
  PMID 26935414DOI 10.1039/c6nr00398b

The 1 most recently updated of 1 ClinicalTrials.gov registrations naming Chromic Chloride as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Effects of Chromium on Insulin Resistance in Alzheimer Disease Patients
  Unknown · Interventional · 100 enrolled · Metabolic Therapy Inc.
  NCT03038282updated 2017-01-31

Frequently asked questions

What is Chromic Chloride used for?

According to FDA labeling, Chromic Chloride carries indications including: Chromium 4 mcg/mL (Chromic Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for TPN. Administration helps to maintain chromium serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What are the brand names for Chromic Chloride?

Chromic Chloride is marketed under brand names including Multitrace-4, Multitrace-5.

What are the contraindications for Chromic Chloride?

Chromic Chloride labeling lists contraindications including: None known.. Always consult the full prescribing information and a clinician.