Cobamamide

Vitamin B 12 [ TREATMENT ]; FOLATE [ PREVENTION ]; OTHER [ SUPPLEMENTATION ];

• EnBrace HR ® is indicated in the TREATMENT of vitamin deficiency - specifically vitamin B 12 deficiency, and the PREVENTION of vitamin B 12 -cofactor deficiency, l-methylfolate. Requirements of vitamin B 9 and/or vitamin B 12 in excess of normal due to pregnancy can usually be met with oral supplementation.

​: The recommended dosage is one (1) capsule daily, preferably on an empty stomach. Dosage may be adjusted by a healthcare provider based on individual patient needs. As a general rule reticulocyte plasma count, folate and vitamin B 12 status must be obtained prior to treatment. Do not exceed the recommended dose. Call your medical practitioner about side effects. You may report side effects by calling (866) 280-5961.

Mild transient diarrhea, polycythemia vera, itching, transitory exanthema, feeling of swelling of entire body may occur with administration of vitamin B 12 . Allergic sensitization has been reported following both oral and parenteral administration of folic acid.

1. 1Abnormal Dreams114%
2. 2Agranulocytosis114%
3. 3Anxiety Disorder114%
4. 4Catheter Site Erythema114%
5. 5Catheter Site Irritation114%
6. 6Clostridium Difficile Infection114%
7. 7Cognitive Disorder114%
8. 8Drug Ineffective114%
9. 9Dysarthria114%
10. 10Foot Operation114%
11. 11Hallucination114%
12. 12Infusion Site Pain114%
13. 13Infusion Site Urticaria114%
14. 14Injection Site Pain114%
15. 15Insomnia114%

The 3 most recently updated of 3 ClinicalTrials.gov registrations naming Cobamamide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.
  Recruiting · Interventional · 111 enrolled · S.LAB (SOLOWAYS)
  NCT06264570updated 2025-06-08
• Phase 2 Study of HL-009 Liposomal Gel to Treat Mild to Moderate Atopic Dermatitis
  Completed · Phase 2 · Interventional · 120 enrolled · HanAll BioPharma Co., Ltd.
  NCT01568489updated 2025-04-22
• The Role of Cobamamide Supplements in Malnourished Patients
  Unknown · Interventional · 124 enrolled · Fakultas Kedokteran Universitas Indonesia
  NCT05944744updated 2023-07-13

Frequently asked questions

How does Cobamamide work?

Vitamin B 12 [ TREATMENT ]; FOLATE [ PREVENTION ]; OTHER [ SUPPLEMENTATION ];

What is Cobamamide used for?

According to FDA labeling, Cobamamide carries indications including: EnBrace HR ® is indicated in the TREATMENT of vitamin deficiency - specifically vitamin B 12 deficiency, and the PREVENTION of vitamin B 12 -cofactor deficiency, l-methylfolate. Requirements of vitamin B 9 and/or vitamin B 12 in excess of normal due to pregnancy can usually be met with oral supplementation.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Cobamamide?

Cobamamide is classified as Vitamin B12 (cyanocobalamin and analogues).