Corticotropin

Mechanism-of-action class: Pituitary Hormone Receptor Agonists.

• USES TAKE 15 MINUTES BEFORE MEALS

DIRECTIONS Take 15 minutes before meals Adults : 20 drops in a little water, 2 times per day

Stop use and ask doctor if symptoms persist more than 5 days. If pregnant or breast-feeding ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Contains ethyl alcohol 30%

• Apr 29, 1952NDANDA008372Mallinckrodt Ireland
• Jun 16, 1954NDANDA008975Ani Pharms

1. 1Fatigue918.6%
2. 2Drug Ineffective767.2%
3. 3Multiple Sclerosis Relapse706.6%
4. 4Headache656.2%
5. 5Asthenia504.7%
6. 6Condition Aggravated474.5%
7. 7Malaise454.3%
8. 8Pain413.9%
9. 9Gait Disturbance403.8%
10. 10Nausea403.8%
11. 11Diarrhoea393.7%
12. 12Fall393.7%
13. 13Insomnia383.6%
14. 14Dizziness373.5%
15. 15Off Label Use373.5%

Recent PubMed references pinned to Corticotropin as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• ACTH independent Cushing's syndrome: Diagnosis and etiology.
  Vitamins and hormones · 2026 · Ortiz-Flores AE
  PMID 42236016DOI 10.1016/bs.vh.2026.02.001
• Differential diagnosis of ACTH-dependent Cushing's syndrome: Biochemical, imaging, and predictive approaches.
  Vitamins and hormones · 2026 · Rivera-Martínez WA, Builes-Montaño CE, Román-González A, et al.
  PMID 42236007DOI 10.1016/bs.vh.2026.03.002
• Avoiding false-positive adrenal insufficiency diagnoses in children: insights from cortisol kinetics during pediatric low-dose ACTH stimulation test.
  European journal of pediatrics · 2026 · Tepe D, Çetin SK, Gökdemir İ, et al.
  PMID 42228004DOI 10.1007/s00431-026-07129-5
• Adrenocorticotropin hormone regulates sphingosine-1-phosphate synthesis via cortisol in bovine adrenocortical cells.
  Biochemical and biophysical research communications · 2026 · Medina-Moctezuma ZB, Guzmán-Sánchez A, González-Aretia D, et al.
  PMID 42176386DOI 10.1016/j.bbrc.2026.153994
• Utility of the post-cosyntropin urinary metabolomic profile for the subtype diagnosis of primary aldosteronism.
  Journal of hypertension · 2026 · Araujo-Castro M, Hanzu FA, Goi J, et al.
  PMID 42160134DOI 10.1097/HJH.0000000000004329
• Daily administration of long-acting adrenocorticotropic hormone (ACTH) alters the developmental pattern of plasma fibrinogen in juvenile rats.
  Brain & development · 2026 · Takeda Y, Sakakibara T, Horiuchi K, et al.
  PMID 42114184DOI 10.1016/j.braindev.2026.104541
• Comparison of in vitro degradation of immunoreactive adrenocorticotropic hormone and insulin in equine blood measured by two immunoassay methods.
  Domestic animal endocrinology · 2026 · Durham AE, Gautam SS, Huber L, et al.
  PMID 42097040DOI 10.1016/j.domaniend.2026.107020
• Case report and literature review: isolated ACTH deficiency induced by combined nivolumab and trastuzumab therapy in gastric adenocarcinoma.
  Frontiers in endocrinology · 2026 · Shi L, Wang J, Xie X, et al.
  PMID 42087875DOI 10.3389/fendo.2026.1742701

The 10 most recently updated of 221 ClinicalTrials.gov registrations naming Corticotropin as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Imaging CRF X NOP Interactions in CUD
  Recruiting · Early phase 1 · Interventional · 80 enrolled · Rajesh Narendran
  NCT05008146updated 2026-06-09
• CRF2 Agonist for the Treatment of Worsening Heart Failure
  Active not recruiting · Phase 2 · Interventional · 300 enrolled · Corteria Pharmaceuticals
  NCT06815471updated 2026-06-08
• FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease
  Recruiting · Early phase 1 · Interventional · 50 enrolled · Mayo Clinic
  NCT07460232updated 2026-05-29
• Combination Osilodrostat and Cabergoline in Cushing's Disease
  Enrolling by invitation · Phase 4 · Interventional · 50 enrolled · University of Basrah
  NCT07603466updated 2026-05-22
• A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
  Recruiting · Phase 2 · Interventional · 218 enrolled · Astellas Pharma Global Development, Inc.
  NCT07005154updated 2026-05-01
• Use of CXCL9 as a Biomarker of Acthar Efficacy
  Terminated · Phase 4 · Interventional · 2 enrolled · University of California, San Francisco
  NCT02523092updated 2026-04-30
• Treatment of CNS Sarcoidosis With H.P. Acthar Gel
  Completed · Phase 4 · Interventional · 4 enrolled · University of Maryland, Baltimore
  NCT02298491updated 2026-04-17
• Cardiorespiratory Fitness Training in Patients With Incomplete Spinal Cord Injury
  Terminated · Interventional · 19 enrolled · Sint Maartenskliniek
  NCT06259227updated 2026-04-16
• Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Syndrome
  Recruiting · Phase 2 · Interventional · 12 enrolled · RECORDATI GROUP
  NCT03708900updated 2026-03-27
• Use of Acthar in Patients With FSGS That Will be Undergoing Renal Transplantation
  Completed · Phase 3 · Interventional · 15 enrolled · University of Colorado, Denver
  NCT02683889updated 2026-03-23

Frequently asked questions

How does Corticotropin work?

Mechanism-of-action class: Pituitary Hormone Receptor Agonists.

What is Corticotropin used for?

According to FDA labeling, Corticotropin carries indications including: USES TAKE 15 MINUTES BEFORE MEALS. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Corticotropin?

Corticotropin is classified as ACTH, Adrenocorticotropic Hormone, Pituitary Hormone Receptor Agonists, Increased Glucocorticoid Secretion, Increased Mineralocorticoid Secretion.

What are the brand names for Corticotropin?

Corticotropin is marketed under brand names including Acthar, Cortrophin.