Croton Oil
US-FDASourced from openFDA
GET
/api/v1/drug/croton-oilIndications
Sourced from openFDA- Pustular eruptions.
Dosage & administration
Sourced from openFDASUGGESTED DOSAGE One dropper under tongue two times daily. Acute symptoms ½ dropper under tongue every 30 minutes for two hours.
Warnings & precautions
Sourced from openFDAUse only if cap seal is unbroken. If pregnant or breastfeeding, ask a healthcare professional before use. Keep this and all medication out of the reach of children.
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
486 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Diarrhoea336.8%
- 2Pain336.8%
- 3Headache306.2%
- 4Fatigue296.0%
- 5Nausea275.6%
- 6Arthralgia265.3%
- 7Dizziness255.1%
- 8Pain In Extremity214.3%
- 9Asthenia183.7%
- 10Abdominal Pain Upper173.5%
- 11Eye Pain173.5%
- 12Fall173.5%
- 13Gait Disturbance173.5%
- 14Muscle Spasms173.5%
- 15Dyspnoea163.3%
Literature
Recent PubMed references pinned to Croton Oil as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Adjunct Perioral Phenol-Croton Oil Peel Shortens Philtrum Length in Patients Undergoing Primary Facelift.Aesthetic surgery journal · 2026 · Janssen PL, Darras O, Fraiman E, et al.PMID 41433344DOI 10.1093/asj/sjaf262
- Phenol-Croton Oil Application in the Treatment of Xanthelasma Palpebrarum.Journal of cosmetic dermatology · 2025 · Akoglu G, Tecik APMID 41252544DOI 10.1111/jocd.70551
- Characterization of the Effects of Dermal Tattoo Machine Delivery versus Conventional Topical Delivery of Croton Oil and Hetter Phenol-Croton Oil Formula.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026 · Ghanian S, Claudia Morais de Oliveira Capote A, da Silva Justo A, et al.PMID 41081308DOI 10.1097/DSS.0000000000004898
- Antioxidant and Anticancer Activity of Tamarix Indica Aerial Extracts against DMBA/croton Oil-Induced Skin Carcinogenesis in Mice.Asian Pacific journal of cancer prevention : APJCP · 2025 · Kadian JP, Kaushik ML, Singh AD, et al.PMID 40022720DOI 10.31557/APJCP.2025.26.2.701
- Co-administration of Ayurvedic medicines Arshogrit and Jatyadi Ghrit, attenuate croton oil-induced hemorrhoids in rat model of recto-anal inflammation by modulating TNF-α and IL-1β levels.Drug development and industrial pharmacy · 2024 · Balkrishna A, Tiwari A, Maity M, et al.PMID 39565131DOI 10.1080/03639045.2024.2432595
- Treatment of Acne Scars with Microneedling and Chemical Reconstruction of Scarred Skin Therapy (CROSS) Using Penol/Croton Oil Combination.Journal of drugs in dermatology : JDD · 2024 · Lopez QPMID 38834218DOI 10.36849/JDD.7657
- Comparative long-term efficacy of phenol-croton oil chemical peels for persistent melasma at varied Croton tiglium oil concentrations.Journal of the American Academy of Dermatology · 2024 · Maymone MBC, Mirza FN, Steiner D, et al.PMID 38574769DOI 10.1016/j.jaad.2024.03.034
- Updates on level of evidence of clinical efficacy of facial phenol-croton oil peels and comments on history and mechanisms of action.International journal of dermatology · 2023 · Wambier CG, Lin E, da Costa Filha ARC, et al.PMID 36325741DOI 10.1111/ijd.16485
Clinical trials
The 2 most recently updated of 2 ClinicalTrials.gov registrations naming Croton Oil as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Comparative Effects Of Trichloroacetic Chemical Peel And Fractional LaserActive not recruiting · Interventional · 120 enrolled · Jose Roberto CortelliNCT07036302updated 2026-05-19
- Histological Skin Changes of Different Peeling Agents in Surgically Subcutaneous Undermined SkinCompleted · Interventional · 9 enrolled · University Hospital TuebingenNCT02848209updated 2017-03-20
Frequently asked questions
- What is Croton Oil used for?
- According to FDA labeling, Croton Oil carries indications including: Pustular eruptions.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
Note. Data for
croton-oil is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.