Estriol
Estrogens, combinations with other drugsNatural and semisynthetic estrogens, plainUS-FDASourced from openFDA
GET
/api/v1/drug/estriolIndications
Sourced from openFDA- Helps improve skin tone and texture associated with estrogen decline Supports hydration, firmness, and elasticity in aging skin Helps relieve menopausal discomfortsICD-10: N95.1
Dosage & administration
Sourced from openFDAapply 1 pump daily to the face, neck, chest, inner thighs or arms message gently until fully absorbed
Warnings & precautions
Sourced from openFDAFor external use only on broken or irritated skin keep out of eyes. if rash or irritation occurs If pregnant, nursing, or undergoing hormone-related treatment, consult a qualified healthcare professional before use. Keep out of reach of children
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
1,688 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Nausea48929%
- 2Fatigue45127%
- 3Diarrhoea44226%
- 4Headache44226%
- 5Dyspnoea41825%
- 6Vomiting40724%
- 7Dizziness40624%
- 8Pain40024%
- 9Malaise39623%
- 10Arthralgia38623%
- 11Feeling Abnormal37522%
- 12Palpitations37422%
- 13Pyrexia37422%
- 14Insomnia37322%
- 15Alopecia37022%
Literature
Recent PubMed references pinned to Estriol as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Estetrol (E4) for the treatment of moderate to severe vasomotor symptoms in postmenopausal women - Efficacy and safety results from the phase 3 E4COMFORT I multicenter, placebo-controlled study.Maturitas · 2026 · Simoncini T, Bouchard C, Cloes M, et al.PMID 42068869DOI 10.1016/j.maturitas.2026.108965
- Continuous estetrol/drospirenone regimen for the treatment of endometriosis-related pain: preliminary results.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2026 · Dell'Aquila M, Della Corte L, Kafetzis D, et al.PMID 42018156DOI 10.1080/09513590.2026.2662694
- Estetrol-based combined oral contraceptives: A systematic review of clinical outcomes.Acta obstetricia et gynecologica Scandinavica · 2026 · Råberg M, Vad IR, Axelsdóttir KH, et al.PMID 41988925DOI 10.1111/aogs.70203
- Prenatal Screening for Fetal X-Linked Ichthyosis: A Large Cohort Study Combining Non-Invasive Prenatal Testing and Maternal Serum Unconjugated Estriol Analysis.Prenatal diagnosis · 2026 · Han M, Chen M, Du Y, et al.PMID 41888405DOI 10.1002/pd.70139
- Estetrol Enhances Mitochondrial Bioenergetics and Neurite Outgrowth in Cellular Models of Alzheimer's Disease.Cells · 2026 · Grimm A, Riou A, Gaillard C, et al.PMID 41827885DOI 10.3390/cells15050452
- A concept for a new approach to combined oral contraception from adolescence to perimenopause: Continuous use of the oral GnRH antagonist Relugolix and the fetal estrogen Estetrol.Acta obstetricia et gynecologica Scandinavica · 2026 · Coelingh Bennink HJT, Afors K, Bahamondes L, et al.PMID 41793206DOI 10.1111/aogs.70182
- Randomized clinical trial of vaginal microbiota in menopausal genitourinary syndrome using radiofrequency and topical estriol.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025 · Zunino AX, Torre PA, Cristina Aidé Viviani S, et al.PMID 41415710DOI 10.61622/rbgo/2025rbgo85
- Delayed start of estetrol drospirenone versus ethinyl estradiol gestodene for ovulation inhibition in a noninferiority randomized controlled trial.Scientific reports · 2025 · Ittipuripat S, Phutrakool P, Uaamnuichai S, et al.PMID 41388035DOI 10.1038/s41598-025-27467-y
Clinical trials
The 10 most recently updated of 78 ClinicalTrials.gov registrations naming Estriol as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy.Active not recruiting · Phase 4 · Interventional · 160 enrolled · University Hospital, GhentNCT05562518updated 2026-04-30
- Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of MenopauseRecruiting · Interventional · 60 enrolled · University of Nove de JulhoNCT06873971updated 2026-04-23
- The Effects of Adjunctive Therapy With Vaginal Tablets Lactobacillus Acidophilus and a Low Dose Estriol (Gynoflor®) to Prolong Pregnancy Time in Preterm Labor, A Randomized Controlled TrialNot yet recruiting · Interventional · 80 enrolled · Queen Savang Vadhana Memorial Hospital, ThailandNCT07344064updated 2026-01-15
- Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort II)Completed · Phase 3 · Interventional · 1,015 enrolled · EstetraNCT04090957updated 2025-12-26
- Microbiome-Modulating Prophylaxis RCT: Antibiotic vs Gynoflor in Postmenopausal Women With Recurrent CystitisRecruiting · Phase 4 · Interventional · 100 enrolled · Mahidol UniversityNCT07186465updated 2025-09-25
- Comparing the Effects of Sublingual Estradiol Treatment Versus Oral Estradiol With Cyproterone Acetate (CPA) Treatment on The Coagulation System in Transgender Women: A Prospective, Controlled Cohort StudyCompleted · Interventional · 30 enrolled · Tel-Aviv Sourasky Medical CenterNCT07145281updated 2025-08-28
- Reducing Pregnancy Risks: The Mastery Lifestyle InterventionRecruiting · Interventional · 238 enrolled · Microgen LLCNCT05012072updated 2025-07-17
- "Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation InhibitionCompleted · Interventional · 36 enrolled · Chulalongkorn UniversityNCT06396221updated 2025-05-20
- LASER and Radiofrequency for Treatment of Vaginal Vulvar Atrophy (VVA) in Women Treated for Breast Cancer (EPMLARF-arm2)Active not recruiting · Interventional · 195 enrolled · Federal University of São PauloNCT04081805updated 2025-04-24
- LASER and Radiofrequency and Genitourinary Syndrome of MenopauseActive not recruiting · Interventional · 195 enrolled · Federal University of São PauloNCT04045379updated 2025-04-22
Frequently asked questions
- What is Estriol used for?
- According to FDA labeling, Estriol carries indications including: Helps improve skin tone and texture associated with estrogen decline Supports hydration, firmness, and elasticity in aging skin Helps relieve menopausal discomforts. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Estriol?
- Estriol is classified as Estrogens, combinations with other drugs, Natural and semisynthetic estrogens, plain.
- What are the brand names for Estriol?
- Estriol is marketed under brand names including Incurin.
Note. Data for
estriol is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.