Eucalyptol
/api/v1/drug/eucalyptolIndications
Sourced from openFDA- Use helps control plaque that leads to gingivitis
Dosage & administration
Sourced from openFDADirections adults and children 12 years of age and older - vigorously swish 20 mL (2.3 FL OZ or 4 teaspoonfuls) between teeth for 30 seconds then spit out; do not swallow children under 12 years of age - consult a dentist or doctor this rinse is not intended to replace brushing or flossing
Warnings & precautions
Sourced from openFDAfor this product Do not use if you have painful or swollen gums, pus from the gum line, loose teeth or increased spacing between the teeth. See your dentist immediately. these may be signs of periodontitis, a serious form of gum disease. Stop use and ask a dentist if gingivitis, bleeding or redness persists for more than 2 weeks. Keep out of reach of children. If more than used for rinsing is accidentally swallowed, get medical help or contact a Poison Control Center right away.
Adverse reactions
Sourced from openFDAAdverse Reaction *This product is not manufactured or distributed by Kenvue, Inc., distributor of FreshBurst ® Listerine ® Antiseptic Mouthwash. OUR PROMISE: Gluten Free** **While this product has no added gluten, there is no guarantee that this product's ingredients have not been exposed to gluten. DISTRIBUTED BY: RITE AID 200 NEWBERRY COMMONS ETTERS, PA 17319 www.riteaid.com SATISFACTION GUARANTEE If you're not satisfied, we'll happily refund your money. DSP-TN-21091 DSP-MO-20087
FAERS reports
- 1Fatigue1467.7%
- 2Nausea1467.7%
- 3Diarrhoea1236.5%
- 4Dizziness1146.0%
- 5Pain1146.0%
- 6Headache1095.8%
- 7Dyspnoea965.1%
- 8Arthralgia914.8%
- 9Drug Ineffective914.8%
- 10Vomiting834.4%
- 11Pain In Extremity774.1%
- 12Asthenia733.9%
- 13Pruritus713.7%
- 14Rash643.4%
- 15Insomnia613.2%
Literature
Recent PubMed references pinned to Eucalyptol as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- 1,8-cineole as a multi-target anticancer candidate integrating molecular mechanisms, pharmacokinetics and translational perspectives.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026 · Lu D, Zhang L, Akdaş EY, et al.PMID 42070456DOI 10.1016/j.biopha.2026.119467
- Anti-inflammatory effects of 1,8-cineol via NF-κB/COX-2 pathway in BEAS-2B cells and alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice.Frontiers in immunology · 2026 · Wang Y, Zhu J, Zhang X, et al.PMID 41972189DOI 10.3389/fimmu.2026.1714915
- Magnoliae flos (Shin-i) Essential Oil and Its Principal Component Eucalyptol Inhibit JAK1 to Counteract the LPS-Induced RAW264.7 Inflammation.Chemistry & biodiversity · 2026 · Wang W, Zhang X, Ou P, et al.PMID 41779444DOI 10.1002/cbdv.202501983
- Rational Enzyme Modification and Expression Enhancement Strategies for 1,8-cineole Production in Serratia marcescens Cell Factories.Applied biochemistry and biotechnology · 2026 · Wang C, Gou L, Liu D, et al.PMID 41484735DOI 10.1007/s12010-025-05544-2
- Direct loading versus chitosan nanoparticles encapsulation of 1,8-cineole and eucalyptus oil in PVA-based nanofibers: Box-Behnken optimization, sustained delivery, antibacterial, and wound healing activities.International journal of biological macromolecules · 2026 · Shetta A, Husien S, Khalil EA, et al.PMID 41478483DOI 10.1016/j.ijbiomac.2025.149988
- Odorant receptor CaspOR39 underpinned cineole-mediated oviposition repellency in the rape stem weevil Ceutorhynchus asper.Insect biochemistry and molecular biology · 2026 · Rao F, Yang J, Peng D, et al.PMID 41468975DOI 10.1016/j.ibmb.2025.104473
- Unraveling the antibacterial mechanism of eucalyptol against Escherichia coli O157:H7 through transcriptomics and its application in beef broth.International journal of food microbiology · 2026 · He Y, Wang Y, He Y, et al.PMID 41406565DOI 10.1016/j.ijfoodmicro.2025.111580
- Eucalyptol-based dispersive liquid-liquid microextraction in conjunction with GC-MS for phthalate esters determination in bottled water samples.Analytica chimica acta · 2025 · Bałdowska A, Makoś-Chełstowska P, Płotka-Wasylka J, et al.PMID 40983437DOI 10.1016/j.aca.2025.344491
Clinical trials
The 10 most recently updated of 29 ClinicalTrials.gov registrations naming Eucalyptol as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Antibacterial Mouthwash for Pharyngeal Gonorrhea PreventionCompleted · Phase 2 · Interventional · 89 enrolled · University of California, Los AngelesNCT04966507updated 2026-02-13
- The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth WashesRecruiting · Interventional · 44 enrolled · King Abdullah University HospitalNCT07364565updated 2026-01-23
- Study of Gum Tissue Proteins in Smokers vs. Non-smokers After CleaningCompleted · Interventional · 36 enrolled · Al-Azhar UniversityNCT07339670updated 2026-01-14
- Comparison Of Clinical Effects Of Listerine And Chlorhexidine Mouth Wash In Patients Undergoing Fixed Orthodontic TreatmentRecruiting · Interventional · 60 enrolled · Khyber Medical University PeshawarNCT07119840updated 2025-11-26
- Topical Versus Injection PRP for Olfactory DysfunctionNot yet recruiting · Phase 3 · Interventional · 60 enrolled · Taipei Veterans General Hospital, TaiwanNCT07151703updated 2025-09-03
- Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19)Withdrawn · Phase 4 · Interventional · 0 enrolled · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sNCT04374474updated 2025-08-01
- Olfactory Function and Delayed Neurocognitive RecoveryCompleted · Interventional · 131 enrolled · Shanghai 10th People's HospitalNCT03441074updated 2025-07-31
- Carbohydrates and Running PerformanceCompleted · Interventional · 36 enrolled · University of GeorgiaNCT06742398updated 2025-07-24
- The Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory DysfunctionRecruiting · Interventional · 150 enrolled · Peking University Third HospitalNCT06829706updated 2025-02-17
- Minimally Invasive Non-surgical Therapy for the Treatment of Splinted Stage IV PeriodontitisCompleted · Interventional · 40 enrolled · Minia UniversityNCT06772506updated 2025-01-14
Frequently asked questions
- What is Eucalyptol used for?
- According to FDA labeling, Eucalyptol carries indications including: Use helps control plaque that leads to gingivitis. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Eucalyptol?
- Eucalyptol is classified as Expectorants.
- What are the brand names for Eucalyptol?
- Eucalyptol is marketed under brand names including Listerine Antiseptic, Listerine Ultraclean.
eucalyptol is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.