Eugenol
/api/v1/drug/eugenolMechanism of action
Sourced from openFDAMechanism-of-action classes: Immunologic Factor Interactions; Unknown Cellular or Molecular Interaction.
Indications
Sourced from openFDA- Uses temporarily relieves throbbing, persistent toothache due to a cavity until a dentist can be seen
Dosage & administration
Sourced from openFDADirections rinse tooth with water to remove any food particles from the cavity using tweezers, immerse cotton pellet in medication to prevent dripping , squeeze gently between fingers to remove excess liquid place pellet in tooth cavity for one minute without touching surrounding tissues , then remove supervise children using this product adults and children 12 years and over: use up to 4 times daily or as directed by a dentist or doctor children under 12 years: ask a dentist or doctor
Warnings & precautions
Sourced from openFDAFor external use only Allergy alert: do not use if you are allergic to eugenol (clove oil) When using this product use only in teeth with persistent, throbbing pain avoid touching tissues other than tooth cavity. Contact with lips or mucous membranes can cause burning, swelling, or irritation. DO NOT SWALLOW to avoid irritation do not use for more than 7 days do not exceed recommended dosage Stop use and ask a dentist or doctor if irritation persists, inflammation develops, or if fever and infection develop See a dentist as soon as possible whether or not the pain is relieved. Toothaches and open cavities indicate serious problems that need prompt attention by a dentist.
FAERS reports
- 1Chemical Burn416%
- 2Hypersensitivity312%
- 3Fatigue28.0%
- 4Hypoaesthesia28.0%
- 5Swelling28.0%
- 6Abdominal Discomfort14.0%
- 7Aphthous Ulcer14.0%
- 8Bipolar Disorder14.0%
- 9Bronchitis14.0%
- 10Cheilitis14.0%
- 11Condition Aggravated14.0%
- 12Dermatitis14.0%
- 13Diarrhoea14.0%
- 14Dizziness14.0%
- 15Drug Hypersensitivity14.0%
Literature
Recent PubMed references pinned to Eugenol as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Association of Nepeta cataria L. essential oil and eugenol: synergism and safe anesthesia in tambaqui Colossoma macropomum (Cuvier, 1818).Veterinary research communications · 2026 · Damasceno TV, de Sousa Reis T, Lins A, et al.PMID 42207337DOI 10.1007/s11259-026-11298-x
- Glutathione-Chitosan Modified Methyl Eugenol Liposomes Promote Spinal Cord Injury Repair by Alleviating Neuroinflammation.ACS applied materials & interfaces · 2026 · Liu J, Feng H, Liu Y, et al.PMID 42176032DOI 10.1021/acsami.6c05534
- Transcription-coupled nucleotide excision repair protects against genomic instability and cell death induced by the liver toxin methyleugenol.Cell death & disease · 2026 · Quarz C, Walter RS, Hens LE, et al.PMID 42156710DOI 10.1038/s41419-026-08853-4
- Eugenol from Syzygium aromaticum enhances longevity and proteostasis in aged yeast.Biogerontology · 2026 · Suesattayapirom S, Kanhachai T, Puttapong A, et al.PMID 42141132DOI 10.1007/s10522-026-10448-7
- Clinical efficacy and safety of a spray formulation containing carvacrol and eugenol against Rhipicephalus linnaei and Ctenocephalides felis felis in artificially infested dogs.Veterinary parasitology · 2026 · Miranda FR, Bonfim IV, Fernandes AJB, et al.PMID 42127510DOI 10.1016/j.vetpar.2026.110793
- Folic Acid-Conjugated PLGA Nanoparticles of Eugenol: Development, Characterization, and In Vitro Cytotoxicity Studies on Breast Cancer Cell Line.BioMed research international · 2026 · Kashyap B, Khan A, Malik T, et al.PMID 42037176DOI 10.1155/bmri/2898012
- Oral pH-responsive sodium alginate microspheres co-delivering Musca domestica cecropin and eugenol for anti-inflammatory therapy in sepsis.International journal of biological macromolecules · 2026 · Xu S, Liang J, Xu B, et al.PMID 41997316DOI 10.1016/j.ijbiomac.2026.152049
- Isoeugenol Inhibits Growth, Migration, and Invasion in Colorectal Cancer Cells With Distinct Molecular Characteristics.Molecular nutrition & food research · 2026 · Liou ZS, Kuo CC, Yeh CC, et al.PMID 41988864DOI 10.1002/mnfr.70466
Clinical trials
The 10 most recently updated of 106 ClinicalTrials.gov registrations naming Eugenol as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized TrialNot yet recruiting · Early phase 1 · Interventional · 110 enrolled · University of Sao PauloNCT07542639updated 2026-05-12
- Endodontic Post-operative Pain Evaluation of Patients After Using Endomethasone N or Endomethasone SP (EndoPOP)Completed · Interventional · 300 enrolled · SeptodontNCT04885686updated 2026-05-06
- Tooth Retention After Root Canal Treatment With Endomethasone NActive not recruiting · Observational · 179 enrolled · SeptodontNCT04945993updated 2026-05-06
- Comparative Evaluation of Three Different Pulpotomy Agents in Primary MolarsActive not recruiting · Phase 2 · Interventional · 165 enrolled · Al-Mustansiriyah UniversityNCT07541976updated 2026-04-24
- Nano Silver Effect in Rapid Wound HealingCompleted · Interventional · 12 enrolled · Damascus UniversityNCT07521176updated 2026-04-09
- Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)Recruiting · Phase 2 · Phase 3 · Interventional · 145 enrolled · Medical University of South CarolinaNCT05855369updated 2026-04-02
- Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp NecrosisNot yet recruiting · Phase 1 · Phase 2 · Interventional · 180 enrolled · University of FaisalabadNCT07475364updated 2026-03-19
- Counterpain PXM Versus Diclofenac Versus PiroxicamCompleted · Phase 3 · Interventional · 180 enrolled · Taisho Pharmaceutical IndonesiaNCT07475663updated 2026-03-16
- Evaluation of Lesion Sterilization and Tissue Repair Techniques Versus Pulpectomy in Primary Molars With Inflammed PulpCompleted · Interventional · 66 enrolled · Cairo UniversityNCT05336682updated 2026-02-27
- Clinical and Radiographic Assessment of Neo Putty MTA Versus Formocresol Used in Vital Pulpotomy of Mandibular Primary MolarsNot yet recruiting · Interventional · 68 enrolled · October University for Modern Sciences and ArtsNCT07437794updated 2026-02-27
Frequently asked questions
- How does Eugenol work?
- Mechanism-of-action classes: Immunologic Factor Interactions; Unknown Cellular or Molecular Interaction.
- What is Eugenol used for?
- According to FDA labeling, Eugenol carries indications including: Uses temporarily relieves throbbing, persistent toothache due to a cavity until a dentist can be seen. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Eugenol?
- Eugenol is classified as Standardized Chemical Allergen, Immunologic Factor Interactions, Unknown Cellular or Molecular Interaction, Cell-mediated Immunity, Increased Histamine Release, Unknown Physiological Effect.
eugenol is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.