pharmacopeia
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/api/v1/drug/flurbiprofen

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Cyclooxygenase Inhibitors.

Cyclooxygenase

Indications

Sourced from openFDA
  • Flurbiprofen sodium ophthalmic solution is indicated for the inhibition of intraoperative miosis.

Contraindications

Sourced from openFDA
  • Flurbiprofen sodium ophthalmic solution is contraindicated in individuals who are hypersensitive to any components of the medication.contraindicated

Dosage & administration

Sourced from openFDA

A total of four (4) drops of flurbiprofen sodium ophthalmic solution should be administered by instilling one (1) drop approximately every 1/2 hour beginning 2 hours before surgery.

Warnings & precautions

Sourced from openFDA

With some nonsteroidal anti-inflammatory drugs, there exists the potential for increased bleeding time due to interference with thrombocyte aggregation. There have been reports that flurbiprofen sodium ophthalmic solution may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery. There is the potential for cross-sensitivity to acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs. Therefore, caution should be used when treating individuals who have previously exhibited sensitivities to these drugs.

Adverse reactions

Sourced from openFDA

Transient burning and stinging upon instillation and other minor symptoms of ocular irritation have been reported with the use of flurbiprofen sodium ophthalmic solution. Other adverse reactions reported with the use of flurbiprofen sodium ophthalmic solution include: fibrosis, hyphema, miosis, mydriasis, and ocular hyperemia. Increased bleeding tendency of ocular tissues in conjunction with ocular surgery has also been reported [see Warnings ]. To report SUSPECTED ADVERSE REACTIONS, contact Bausch & Lomb Incorporated at 1-800-553-5340 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Use in specific populations

Sourced from openFDA

Pregnancy Flurbiprofen has been shown to be embryocidal, delay parturition, prolong gestation, reduce weight, and/or slightly retard growth of fetuses when given to rats in daily oral doses of 0.4 mg/kg (approximately 300 times the human daily topical dose) and above. There are no adequate and well-controlled studies in pregnant women. Flurbiprofen sodium ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Overdosage

Sourced from openFDA

Overdosage will not ordinarily cause acute problems. If accidentally ingested, drink fluids to dilute.

Approval history

Sourced from openFDA
  • Jan 4, 1995ANDAANDA074447Bausch And Lomb
  • May 31, 1995ANDAANDA074431New Heightsrx

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
1,547 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Drug Ineffective1026.6%
  2. 2Off Label Use976.3%
  3. 3Angioedema895.8%
  4. 4Urticaria704.5%
  5. 5Nausea694.5%
  6. 6Arthralgia644.1%
  7. 7Dyspnoea624.0%
  8. 8Pain603.9%
  9. 9Pneumonia573.7%
  10. 10Vomiting573.7%
  11. 11Acute Kidney Injury553.6%
  12. 12Pyrexia553.6%
  13. 13Diarrhoea523.4%
  14. 14Fatigue503.2%
  15. 15Drug Hypersensitivity483.1%

Literature

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Recent PubMed references pinned to Flurbiprofen as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 119 ClinicalTrials.gov registrations naming Flurbiprofen as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Pharmacogenomics

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CPIC-curated drug–gene pairs for Flurbiprofen. Levels describe the strength of curated evidence and guideline status — never a recommendation to test or to adjust therapy.

Frequently asked questions

How does Flurbiprofen work?
Mechanism-of-action class: Cyclooxygenase Inhibitors.
What is Flurbiprofen used for?
According to FDA labeling, Flurbiprofen carries indications including: Flurbiprofen sodium ophthalmic solution is indicated for the inhibition of intraoperative miosis.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Flurbiprofen?
Flurbiprofen is classified as Antiinflammatory agents, non-steroids, Antiinflammatory preparations, non-steroids for topical use, Other throat preparations, Propionic acid derivatives, Nonsteroidal Anti-inflammatory Drug, Cyclooxygenase Inhibitors, Decreased Prostaglandin Production.
What are the brand names for Flurbiprofen?
Flurbiprofen is marketed under brand names including Ansaid, Lurbipr, Lurbiro, Ocufen.
What are the contraindications for Flurbiprofen?
Flurbiprofen labeling lists contraindications including: Flurbiprofen sodium ophthalmic solution is contraindicated in individuals who are hypersensitive to any components of the medication.. Always consult the full prescribing information and a clinician.
Note. Data for flurbiprofen is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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