Folate
/api/v1/drug/folateBoxed warning
Tell your doctor if you have: kidney problems, thyroid disease. This medication should be used as directed during pregnancy or while breast-feeding. Consult your doctor. Administration of folate alone is improper therapy for pernicious anemia and other megaloblastic anemias in which vitamin B12 is deficient. Precautions Folate in doses above 0.1 mg daily may obscure pernicious anemia, in that hematologic remission can occur while neurological manifestations remain progressive. There is a potential danger in administering folate to patients with undiagnosed anemia, since folate may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress. This may result in severe nervous system damage before the correct diagnosis is made. The patient’s medical conditions and consumption of other drugs, herbs, and/or supplements should be considered.
Indications
Sourced from openFDA- For the dietary management of menopausal symptoms and the support of overall health during the menopausal phase.ICD-10: N95.1
Contraindications
Sourced from openFDA- This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Menatrol™ Capsules are contraindicated in patients with hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of vitamin D, and hypervitaminosis D.contraindicated
Dosage & administration
Sourced from openFDATake one (1) capsule daily or as directed by a licensed healthcare practitioner.
Adverse reactions
Sourced from openFDAPossible side effects may include gastrointestinal upset. If any side effects persist or worsen, discontinue use and consult a physician.
Use in specific populations
Sourced from openFDAPregnancy and Lactation: Not recommended for use during pregnancy or lactation without consulting with a licensed healthcare practitioner.
Overdosage
Sourced from openFDAIn case of overdose, seek medical attention immediately. Symptoms may include nausea, vomiting, or diarrhea.
FAERS reports
- 1Abasia114%
- 2Acute Kidney Injury114%
- 3Adenocarcinoma Of Colon114%
- 4Anaemia114%
- 5Arrhythmia114%
- 6Asthenia114%
- 7Benign Prostatic Hyperplasia114%
- 8Chest Discomfort114%
- 9Cystitis114%
- 10Decreased Appetite114%
- 11Discomfort114%
- 12Dizziness114%
- 13Headache114%
- 14Insomnia114%
- 15Iron Deficiency114%
Literature
Recent PubMed references pinned to Folate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Expression of Concern on "Myo-inositol, D-chiro-inositol, folic acid and manganese in second trimester of pregnancy: a preliminary investigation".European review for medical and pharmacological sciences · 2026 · No Authors listedPMID 42237956DOI 10.26355/eurrev_202605_37818
- Association between dietary and circulating folate markers and kidney stones in American adults: A cross-sectional NHANES analysis.Medicine · 2026 · Safargar M, Basiri A, Kord-Varkaneh H, et al.PMID 42216366DOI 10.1097/MD.0000000000048951
- Genetic Susceptibility to Autism Spectrum Disorders: Folate Pathway Polymorphisms, Mediterranean Diet and Evolutionary Insights.Journal of molecular neuroscience : MN · 2026 · Bonifacio MA, Vinella A, Pafundi M, et al.PMID 42213268DOI 10.1007/s12031-026-02552-7
- A Global Update on the Status of Prevention of Folic Acid-Preventable Spina Bifida and Anencephaly in Year 2024.Birth defects research · 2026 · Kancherla V, Wagh K, Pachón H, et al.PMID 42204373DOI 10.1002/bdr2.70065
- Effect of iron dose in maternal multiple micronutrient supplement on perceived side effects, adherence, acceptability and preferences: protocol for a randomised crossover trial.BMJ open · 2026 · Sudfeld CR, Muhihi A, Sylvetsky AC, et al.PMID 42203269DOI 10.1136/bmjopen-2026-118725
- Long-Term Health and Economic Impact of a Community-Based, Gene-Guided, Nutrition Program: The Sakado Folate Project in Japan.Nutrients · 2026 · Kagawa Y, Sakamoto K, Shoji K, et al.PMID 42197090DOI 10.3390/nu18101630
- Associations Between Concentrations of Vitamin D3, Vitamin B12, and Folate and the Well-Being of Medical Students.Nutrients · 2026 · Cieślikiewicz B, Bieńkowska A, Maksymowicz S, et al.PMID 42197019DOI 10.3390/nu18101559
- Zinc Ferrite-Integrated Halloysite Nanotubes as a Platform for Folate-Mediated Targeted Cisplatin Delivery.International journal of molecular sciences · 2026 · Almofty S, Ravinayagam V, Dafalla H, et al.PMID 42196267DOI 10.3390/ijms27104284
Clinical trials
The 10 most recently updated of 2,662 ClinicalTrials.gov registrations naming Folate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha ExpressionRecruiting · Phase 2 · Interventional · 100 enrolled · AbbVieNCT06365853updated 2026-06-12
- Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)Recruiting · Phase 1 · Phase 2 · Interventional · 298 enrolled · Merck Sharp & Dohme LLCNCT06780111updated 2026-06-12
- Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening TrialRecruiting · Phase 2 · Interventional · 2,900 enrolled · National Cancer Institute (NCI)NCT05564377updated 2026-06-12
- A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal AdenocarcinomaRecruiting · Phase 2 · Phase 3 · Interventional · 900 enrolled · AbbVieNCT07490301updated 2026-06-12
- Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal CancerActive not recruiting · Phase 2 · Interventional · 8 enrolled · H. Lee Moffitt Cancer Center and Research InstituteNCT06109467updated 2026-06-12
- A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal CancerRecruiting · Phase 2 · Interventional · 390 enrolled · AbbVieNCT06820463updated 2026-06-12
- A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)Recruiting · Phase 2 · Interventional · 60 enrolled · SCRI Development Innovations, LLCNCT07011576updated 2026-06-12
- Personalize (Signature Driven) Neoadjuvant Chemotherapy Trial for Patients With Resectable Borderline Pancreatic Ductal Adenocarcinoma.Not yet recruiting · Phase 2 · Interventional · 110 enrolled · Federation Francophone de Cancerologie DigestiveNCT07616362updated 2026-06-11
- A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal CancerActive not recruiting · Phase 3 · Interventional · 841 enrolled · PfizerNCT04607421updated 2026-06-11
- Different Efficacy of IFA Supplementation Among Obese and Non-obese WomenCompleted · Interventional · 165 enrolled · Griffith UniversityNCT06622551updated 2026-06-11
Frequently asked questions
- What is Folate used for?
- According to FDA labeling, Folate carries indications including: For the dietary management of menopausal symptoms and the support of overall health during the menopausal phase.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What are the contraindications for Folate?
- Folate labeling lists contraindications including: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Menatrol™ Capsules are contraindicated in patients with hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of vitamin D, and hypervitaminosis D.. Always consult the full prescribing information and a clinician.
folate is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.