Glucosamine

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

Direction Take 2-3 capsules daily, preferably with a meal.

Other Ingredients Maize starch, Microcrystalline Cellulose, Magnesium Stearate.

1. 1Drug Hypersensitivity217%
2. 2Hospitalisation217%
3. 3Surgery217%
4. 4Acute Respiratory Failure18.3%
5. 5Arthralgia18.3%
6. 6Bacterial Infection18.3%
7. 7Blood Pressure Increased18.3%
8. 8Chronic Disease18.3%
9. 9Complication Associated With Device18.3%
10. 10Death18.3%
11. 11Dermatitis Atopic18.3%
12. 12Device Use Issue18.3%
13. 13Diabetes Mellitus18.3%
14. 14Dust Allergy18.3%
15. 15Fatigue18.3%

Recent PubMed references pinned to Glucosamine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Genetic Rescue of Pathogenic O-GlcNAc Dyshomeostasis Associated with Microcephaly and Motor Deficits.
  eNeuro · 2026 · Authier F, Esperon-Abril I, Coquelin KS, et al.
  PMID 42209020DOI 10.1523/ENEURO.0453-25.2026
• Molecular Modeling of N-Acetylglucosamine Binding to the I154R Mutant of NAGLU: Pathogenic Insights into Sanfilippo Syndrome Type B.
  International journal of molecular sciences · 2026 · Kannan P, Priya Nanda Kumar M, Kumar Nanda Kumar S, et al.
  PMID 42196382DOI 10.3390/ijms27104404
• O-GlcNAc modification regulates autophagy and apoptosis in endometriosis.
  Functional & integrative genomics · 2026 · Jin X, Feng Y, Xu L, et al.
  PMID 42183899DOI 10.1007/s10142-026-01888-y
• Glucosamine links hyperglycemia to mTORC1 activation and glucose toxicity in diabetes.
  JCI insight · 2026 · Riahi Y, Kogot-Levin A, Teselpapa Z, et al.
  PMID 42171606DOI 10.1172/jci.insight.197331
• Systematic Quantification of Protein O-GlcNAcylation Reveals Common and Cell-Type-Specific Responses to N-Glycosylation Inhibition in Human Cells.
  Analytical chemistry · 2026 · Fu L, Yin K, Xu X, et al.
  PMID 42153620DOI 10.1021/acs.analchem.6c00972
• Bifunctional Monosaccharides Preferentially Localize to Nuclear Subcompartments.
  Chembiochem : a European journal of chemical biology · 2026 · Barahtjan P, Iglesias-Artola JM, Böhlig K, et al.
  PMID 42144895DOI 10.1002/cbic.70373
• High glucose impairs cognitive function through Creb3 O-GlcNAcylation and increased lactate production.
  Science signaling · 2026 · Xu J, Yang X, Cao J, et al.
  PMID 41980069DOI 10.1126/scisignal.adx4313
• O-GlcNAc modification orchestrates HUWE1-mediated ubiquitination of TfR1 to regulate ferroptosis and trophoblast syncytialization in preeclampsia.
  Free radical biology & medicine · 2026 · Zhang H, Li M, Zhang J, et al.
  PMID 41962599DOI 10.1016/j.freeradbiomed.2026.04.018

The 10 most recently updated of 144 ClinicalTrials.gov registrations naming Glucosamine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Long-Term Effects of Mobithron Advance on Knee Osteoarthritis Aims to Investigate the Effects of Mobithron Advance on OA Progression
  Recruiting · Early phase 1 · Interventional · 84 enrolled · Universiti Sains Malaysia
  NCT07323745updated 2026-06-12
• A Clinical Study to Evaluate the Efficacy of Native CT-II® in Individuals With Knee Osteoarthritis
  Active not recruiting · Interventional · 114 enrolled · Vedic Lifesciences Pvt. Ltd.
  NCT06917287updated 2026-06-02
• Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free.
  Recruiting · Phase 3 · Interventional · 129 enrolled · Fundación GECP
  NCT06431633updated 2026-05-18
• NT-II™ Collagen for Joint Discomfort and Function
  Recruiting · Interventional · 120 enrolled · Hofseth Biocare ASA
  NCT07119645updated 2026-05-14
• Oral N-acetylglucosamine in Crohn's Disease
  Not yet recruiting · Phase 2 · Interventional · 40 enrolled · Johns Hopkins University
  NCT07225998updated 2026-05-12
• A Trial of a Multi-Component Nutritional Supplement in Hydrogen-Dominant Small Intestinal Bacterial Overgrowth
  Completed · Interventional · 9 enrolled · National University of Natural Medicine
  NCT07215676updated 2026-05-12
• Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian Syndrome
  Recruiting · Phase 3 · Interventional · 276 enrolled · University Hospital, Lille
  NCT03059173updated 2026-04-22
• Combination Gerotherapeutic Interventions for Healthspan Improvement
  Active not recruiting · Phase 3 · Interventional · 30 enrolled · AgelessRx
  NCT07475546updated 2026-03-16
• Kinesiological / Dietary Supplement Intervention in Knee Osteoarthritis
  Active not recruiting · Interventional · 93 enrolled · University of Primorska
  NCT06269549updated 2026-02-23
• Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation.
  Completed · Interventional · 32 enrolled · Taipei Medical University
  NCT06581094updated 2026-01-07

Frequently asked questions

How does Glucosamine work?

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

What class of drug is Glucosamine?

Glucosamine is classified as Other antiinflammatory and antirheumatic agents, non-steroids, Unknown Cellular or Molecular Interaction, Analgesia, Bone Alteration.

What are the brand names for Glucosamine?

Glucosamine is marketed under brand names including Cidaflex, Cosamin, Novipet Joint Support, Novipet Magic Bites, Optiflex-G, Osteo Bi-Flex, Schiff.