Isoleucine

• Take 15 minutes before meals

DIRECTIONS Adults and children 12 years and older 20 drops in a little water, 2 times per day Children between 12 years and 6 years of age 10 drops in a little water, 2 times per day Children under 6 years 5 drops in a glass of water, 2 times per day

Stop use and ask doctor if symptoms persist more than 5 days. If pregnant or breast-feeding ask a health professional before use. Keep out of reach of children . In case of overdose, get medical help or contact a Poison Control Center right away. Contains ethyl alcohol 30%

• Jul 20, 1984NDANDA019018B Braun
• Aug 23, 1984NDANDA018931Baxter Hlthcare
• Sep 6, 1985NDANDA019398Otsuka Icu Medcl
• Oct 17, 1986NDANDA019492Otsuka Icu Medcl
• Dec 19, 1991NDANDA020041Otsuka Icu Medcl
• Dec 19, 1991NDANDA020015Otsuka Icu Medcl
• Mar 26, 1997NDANDA020678Baxter Hlthcare
• Sep 29, 1997NDANDA020734Baxter Hlthcare

1. 1Parenteral Nutrition Associated Liver Disease507.1%
2. 2Nausea446.2%
3. 3Pyrexia405.7%
4. 4Vomiting375.2%
5. 5Chills355.0%
6. 6Death355.0%
7. 7Dyspnoea304.2%
8. 8No Adverse Event304.2%
9. 9Diarrhoea263.7%
10. 10Asthenia243.4%
11. 11Palpitations233.3%
12. 12Pneumonia213.0%
13. 13Pruritus213.0%
14. 14Chest Discomfort202.8%
15. 15General Physical Health Deterioration182.5%

Recent PubMed references pinned to Isoleucine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Inhibition of jasmonic acid-isoleucine conjugating enzyme JAR1 shifts the local and systemic leaf signals and metabolic profiles in Arabidopsis.
  The New phytologist · 2026 · Zeng M, Mithöfer A
  PMID 42076909DOI 10.1111/nph.71192
• Toward life with a 19-amino acid alphabet through generative artificial intelligence design.
  Science (New York, N.Y.) · 2026 · Liu L, Rochereau C, Kozlov S, et al.
  PMID 42060756DOI 10.1126/science.aeb5171
• Adding free leucine to a balanced essential amino acid mixture suppresses intracellular transamination of isoleucine and valine in healthy older adults.
  Clinical nutrition (Edinburgh, Scotland) · 2026 · Knezek SB, Engelen MPKJ, Coyle KS, et al.
  PMID 42013668DOI 10.1016/j.clnu.2026.106659
• Val109 and Ile170 contribute to channel function in Guillardia theta-derived anion channelrhodopsins.
  Scientific reports · 2026 · Yokoyama T, Sugano E, Tabata K, et al.
  PMID 41963388DOI 10.1038/s41598-026-46487-w
• Urinary metabolomics identifies isoleucine as a prognostic biomarker for progression of diabetic kidney disease.
  Frontiers in endocrinology · 2026 · Li Y, Yun D, Kwak SH, et al.
  PMID 41948556DOI 10.3389/fendo.2026.1787886
• Marundihomalkins A-J and Marundisphingalkin A: Triglyceride-Lowering Marine Fungal Alkaloids Featuring Non-amide C-N Linkages between Polyketide and Homoisoleucine or Phytosphingosine.
  Organic letters · 2026 · Li L, Fan RZ, Xu XX, et al.
  PMID 41940971DOI 10.1021/acs.orglett.6c00895
• Substrate l-isoleucine facilitates the hyper inhibition of reveromycin A on human cytoplasmic isoleucyl-tRNA synthetase.
  Archives of biochemistry and biophysics · 2026 · Chen B, Yi F, Qi H, et al.
  PMID 41839287DOI 10.1016/j.abb.2026.110789
• Precursor balancing by reprogramming pyruvate synthesis for high-yield l-isoleucine production in engineered Escherichia coli.
  Bioresource technology · 2026 · Huo X, Xia X, Xue N, et al.
  PMID 41740936DOI 10.1016/j.biortech.2026.134270

The 10 most recently updated of 64 ClinicalTrials.gov registrations naming Isoleucine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD Patients
  Recruiting · Interventional · 120 enrolled · Taipei Medical University
  NCT07619560updated 2026-06-02
• SMART Diets for MASLD
  Recruiting · Phase 2 · Interventional · 102 enrolled · Michigan State University
  NCT07459504updated 2026-06-01
• Effect of Branched-Chain Amino Acid Supplementation on Myopia Progression
  Active not recruiting · Interventional · 108 enrolled · Zhongda Hospital
  NCT07585877updated 2026-05-14
• Isoleucine Addition Treatment Effects in a Controlled Diet Study
  Withdrawn · Interventional · 0 enrolled · Jean L. Fry
  NCT07329088updated 2026-04-15
• Evaluation of the Effect of Kefir Consumption
  Active not recruiting · Observational · 66 enrolled · Sys2Diag
  NCT07522372updated 2026-04-13
• Isoleucine, Leucine, Valine and Tryptophan Requirements in TPN Fed Neonates
  Recruiting · Interventional · 80 enrolled · The Hospital for Sick Children
  NCT06372314updated 2026-04-02
• Pre-Surgical Immunonutrition's Effect on Colorectal Surgery
  Recruiting · Interventional · 126 enrolled · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
  NCT06883422updated 2026-03-27
• Essential Amino Acids and Parkinsons Disease
  Withdrawn · Phase 1 · Interventional · 0 enrolled · University of Arkansas
  NCT06604065updated 2026-03-12
• SmART-TBI: Supplementation With Amino Acid Rehabilitative Therapy in TBI
  Completed · Interventional · 160 enrolled · VA Office of Research and Development
  NCT04603443updated 2026-01-06
• Prandial Metabolic Phenotype in Adults
  Recruiting · Interventional · 50 enrolled · Texas A&M University
  NCT05400733updated 2025-10-01

Frequently asked questions

What is Isoleucine used for?

According to FDA labeling, Isoleucine carries indications including: Take 15 minutes before meals. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What are the brand names for Isoleucine?

Isoleucine is marketed under brand names including Aminosyn 10%, Sulfite-Free, Aminosyn 3.5 % M, Sulfite Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Aminosyn 8.5%, Sulfite-Free, Aminosyn II 10 %, Aminosyn II 15%, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, Aminosyn II 8.5 %, Sulfite-Free.