Leucine

• Take 15 minutes before meals

DIRECTIONS Adults and children 12 years and older 20 drops in a little water, 2 times per day Children between 12 years and 6 years of age 10 drops in a little water, 2 times per day Children under 6 years 5 drops in a glass of water, 2 times per day

Stop use and ask doctor if symptoms persist more than 5 days. If pregnant or breast-feeding ask a health professional before use. Keep out of reach of children . In case of overdose, get medical help or contact a Poison Control Center right away. Contains ethyl alcohol 30%

• Jul 20, 1984NDANDA019018B Braun
• Aug 23, 1984NDANDA018931Baxter Hlthcare
• Sep 6, 1985NDANDA019398Otsuka Icu Medcl
• Oct 17, 1986NDANDA019492Otsuka Icu Medcl
• Dec 19, 1991NDANDA020041Otsuka Icu Medcl
• Dec 19, 1991NDANDA020015Otsuka Icu Medcl
• Mar 26, 1997NDANDA020678Baxter Hlthcare
• Sep 29, 1997NDANDA020734Baxter Hlthcare

1. 1Parenteral Nutrition Associated Liver Disease507.1%
2. 2Nausea446.2%
3. 3Pyrexia405.6%
4. 4Vomiting385.4%
5. 5Chills354.9%
6. 6Death354.9%
7. 7Dyspnoea304.2%
8. 8No Adverse Event304.2%
9. 9Diarrhoea263.7%
10. 10Asthenia243.4%
11. 11Palpitations233.2%
12. 12Pneumonia213.0%
13. 13Pruritus213.0%
14. 14Chest Discomfort202.8%
15. 15General Physical Health Deterioration182.5%

Recent PubMed references pinned to Leucine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Leucine Promotes Mouse Primordial Follicle Activation Via the PI3K/Akt Signaling Pathway.
  Molecular reproduction and development · 2026 · Huang Y, Wei H, Zhang W, et al.
  PMID 42200771DOI 10.1002/mrd.70120
• APN Inhibitor Bestatin Induces MM Cell Differentiation Through the CD79B/BTK/STAT3 Pathway.
  Cells · 2026 · Wang X, Fang C, Li S, et al.
  PMID 42193957DOI 10.3390/cells15100949
• Synthesis of N-Acetyl-D- and -L-Leucine-(13)C(6) Tool Compounds in Neurodegenerative Disease.
  ChemMedChem · 2026 · Crepin D, McGown A, Shepherd D, et al.
  PMID 42140848DOI 10.1002/cmdc.70295
• Impact of leucine-rich diet on placenta's proteomic and metabolomic profiles of pregnant tumor-bearing rats.
  Cancer biology & therapy · 2026 · Dos Santos IF, Salgado CM, Carregari VC, et al.
  PMID 42135921DOI 10.1080/15384047.2026.2670792
• A bilayer carbohydrate hydrogel spatiotemporally modulates the leucine-mTORC1 axis in macrophages to orchestrate wound immunity and regeneration.
  Carbohydrate polymers · 2026 · Niu Z, Gong J, Xia X, et al.
  PMID 42067358DOI 10.1016/j.carbpol.2026.125336
• The olfactory receptor SNIF-1 mediates foraging for leucine-enriched diets in C. elegans.
  eLife · 2026 · Siddiqui R, Mehta N, Ranjith G, et al.
  PMID 42029136DOI 10.7554/eLife.101936
• Cav3.1 is a neuronal leucine sensor that mediates satiety and weight loss in response to dietary protein.
  Cell metabolism · 2026 · Tsang AH, Heeley N, Alcaino C, et al.
  PMID 42025169DOI 10.1016/j.cmet.2026.03.017
• Adding free leucine to a balanced essential amino acid mixture suppresses intracellular transamination of isoleucine and valine in healthy older adults.
  Clinical nutrition (Edinburgh, Scotland) · 2026 · Knezek SB, Engelen MPKJ, Coyle KS, et al.
  PMID 42013668DOI 10.1016/j.clnu.2026.106659

The 10 most recently updated of 308 ClinicalTrials.gov registrations naming Leucine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
  Recruiting · Phase 2 · Interventional · 150 enrolled · Neuron23 Inc.
  NCT06680830updated 2026-06-09
• A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis
  Recruiting · Phase 3 · Interventional · 120 enrolled · Hoffmann-La Roche
  NCT05503264updated 2026-06-08
• A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
  Recruiting · Phase 2 · Interventional · 520 enrolled · Janssen Research & Development, LLC
  NCT05498428updated 2026-06-05
• Pivotal Study of N-acetyl-L-leucine for CACNA1A
  Not yet recruiting · Phase 3 · Interventional · 60 enrolled · IntraBio Inc
  NCT07221292updated 2026-06-04
• Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD Patients
  Recruiting · Interventional · 120 enrolled · Taipei Medical University
  NCT07619560updated 2026-06-02
• Leucine-rich α2-glycoprotein Correlation With Clinical, Endoscopic and Histological Disease Activity of IBD in a EuRopean Context
  Recruiting · Observational · 100 enrolled · Imelda GI Clinical Research Center
  NCT07621783updated 2026-06-02
• SMART Diets for MASLD
  Recruiting · Phase 2 · Interventional · 102 enrolled · Michigan State University
  NCT07459504updated 2026-06-01
• Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors
  Recruiting · Phase 1 · Interventional · 180 enrolled · Zai Lab (Shanghai) Co., Ltd.
  NCT07374848updated 2026-05-28
• Leucine Enriched Essential Amino Acid Powder as an Add-on to a Classic Ketogenic Diet in Refractory Epilepsy
  Completed · Phase 1 · Interventional · 4 enrolled · Elizabeth Anne Thiele
  NCT06387186updated 2026-05-22
• RESvEraTrol in Parkinson's Disease (RESET)
  Not yet recruiting · Phase 2 · Interventional · 30 enrolled · Georgetown University
  NCT07592767updated 2026-05-18

Frequently asked questions

What is Leucine used for?

According to FDA labeling, Leucine carries indications including: Take 15 minutes before meals. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What are the brand names for Leucine?

Leucine is marketed under brand names including Aminosyn 10%, Sulfite-Free, Aminosyn 3.5 % M, Sulfite Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Aminosyn 8.5%, Sulfite-Free, Aminosyn II 10 %, Aminosyn II 15%, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, Aminosyn II 8.5 %, Sulfite-Free.