Magnesium Citrate
/api/v1/drug/magnesium-citrateMechanism of action
Sourced from openFDAMechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions; Stool Bulking Activity.
Indications
Sourced from openFDA- Uses: • For relief of occasional constipation (irregularity).ICD-10: K59.00
Dosage & administration
Sourced from openFDADirections: • shake well before using • drink a full glass (8 ounces) of liquid with each dose • may be taken as a single daily dose or in divided doses adults and children 12 years of age and over 6.5 to 10 fl oz maximum 10 fl oz in 24 hours children 6 to under 12 years of age 3 to 7 fl oz maximum 7 fl oz in 24 hours children 2 to under 6 years of age 2 to 3 fl oz maximum 3 fl oz in 24 hours children under 2 years of age ask a doctor
Warnings & precautions
Sourced from openFDAAsk a doctor before use if you have • Kidney disease • a magnesium restricted diet • Abdominal pain, nausea, or vomiting • Noticed a sudden change in bowel habits that persists over a period of 2 weeks • Already used a laxative for a period longer than 1 week Ask a doctor or pharmacist before use if you are • Taking any other drug. • Take this product 2 or more hours before or after other drugs. Laxatives may affect how other drugs work. Stop use and ask a doctor if you have rectal bleeding or failure to have a bowel movement after use. These could be signs of a serious condition. If pregnant or breast-feeding , ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
FAERS reports
- 1Nausea79914%
- 2Fatigue79614%
- 3Off Label Use74813%
- 4Pain74213%
- 5Drug Ineffective73313%
- 6Diarrhoea72012%
- 7Headache64711%
- 8Asthenia5579.5%
- 9Dyspnoea5549.5%
- 10Dizziness5429.3%
- 11Rash5389.2%
- 12Arthralgia5339.1%
- 13Vomiting5188.8%
- 14Abdominal Pain Upper4868.3%
- 15Gastrooesophageal Reflux Disease4627.9%
Literature
Recent PubMed references pinned to Magnesium Citrate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Magnesium supplementation did not reduce serum calciprotein crystallization and arterial stiffness in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.The American journal of clinical nutrition · 2026 · Meer R, Xu JY, Newsom SP, et al.PMID 41903889DOI 10.1016/j.ajcnut.2026.101299
- Single Center, Open-Label, Randomized Crossover Trial on Drug-Drug Interactions of Levothyroxine/Magnesium-Citrate and Levothyroxine/Magnesium-Aspartate in Healthy Subjects-The ThyroMag Trial.Clinical and translational science · 2025 · Attinger MC, von Felten S, Rodrigues CL, et al.PMID 41221788DOI 10.1111/cts.70409
- Preliminary non-comparative evaluation of an adapted colonoscopy preparation protocol for dogs using sodium picosulphate and magnesium citrate.The Veterinary record · 2026 · Elia da Silva Paranhos J, Guillen Gonçalves de Souza M, Araujo de Sousa D, et al.PMID 40856145DOI 10.1002/vetr.5432
- Evaluation of citrate-based nutraceutical combinations and their impact on chemolysis in the management of urinary diversion device: a randomised double-blind placebo-controlled study on improved quality of life and clinical outcomes.World journal of urology · 2025 · Ricapito A, Schiavone N, Finati M, et al.PMID 40715538DOI 10.1007/s00345-025-05788-x
- Novel method for autologous peripheral blood stem cell harvest using highly concentrated sodium citrate solution replacing acid citrate dextrose solution A.Transfusion · 2025 · Kitamura W, Fujii K, Abe M, et al.PMID 40708443DOI 10.1111/trf.18360
- Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways.Science advances · 2025 · Xu H, Tan X, Gerhard E, et al.PMID 40700481DOI 10.1126/sciadv.ady2862
- Self-healing and recyclable vitrimers enabled by dual-dynamic cross-linked networks with biomass citric acid-diaminodecane salt modified hydrotalcites.International journal of biological macromolecules · 2025 · Cui C, Zhang Y, Song W, et al.PMID 40403802DOI 10.1016/j.ijbiomac.2025.144431
- Type-dependent biostimulant-mediated induction of nutrients and phenolic compounds improved plant tolerance against canola aphids (Brevicoryne brassicae L.).Plant physiology and biochemistry : PPB · 2025 · Javed MW, Mansoor-Ul-Hasan, Sagheer M, et al.PMID 40327901DOI 10.1016/j.plaphy.2025.109930
Clinical trials
The 10 most recently updated of 172 ClinicalTrials.gov registrations naming Magnesium Citrate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Potential Therapeutic Role of Effervescent Calcium-Magnesium Citrate in Chronic Kidney Disease Stage VActive not recruiting · Phase 2 · Phase 3 · Interventional · 269 enrolled · University of Texas Southwestern Medical CenterNCT03565913updated 2026-06-03
- Immune-Mitochondrial Correction in Military RecruitsNot yet recruiting · Interventional · 200 enrolled · MIPO ClinicNCT07622147updated 2026-06-02
- The Clinical Trail to Evaluate the Efficacy and Safety of Anaprazole Sodium Enteric-coated Tablets Combined With Bismuth-containing Quadruple Therapy in Eradicating Helicobacter PyloriNot yet recruiting · Phase 3 · Interventional · 556 enrolled · Xuanzhu Biopharmaceutical Co., Ltd.NCT07606833updated 2026-05-26
- Assessment of Safety, Quality, and Acceptance of a Bowel Preparation Using a Food Kit With LaxativesCompleted · Phase 4 · Interventional · 57 enrolled · Joseph SpataroNCT07605897updated 2026-05-26
- Comparison of 1 Liter PEG With Ascorbate and Sodium Picosulfate / Magnesium Citrate for High Quality Colon CleansingCompleted · Phase 4 · Interventional · 1,180 enrolled · Parc de Salut MarNCT04598880updated 2026-05-14
- Magnesium Supplementation as a Nutritional Intervention in SarcopeniaNot yet recruiting · Interventional · 352 enrolled · Escola Superior de Saúde - Universidade do AlgarveNCT07567963updated 2026-05-08
- Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Serum Magnesium LevelsCompleted · Interventional · 54 enrolled · Universitaire Ziekenhuizen KU LeuvenNCT07565779updated 2026-05-04
- A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia MyelofibrosisActive not recruiting · Phase 3 · Interventional · 407 enrolled · Swedish Orphan BiovitrumNCT03165734updated 2026-04-30
- Preventive Nutritional Supplements for Preclinical PathologiesCompleted · Interventional · 21 enrolled · Centro de Edafología y Biología Aplicada del SeguraNCT07265115updated 2026-04-28
- Intestinal Microbiome Transplant in ALSRecruiting · Phase 1 · Phase 2 · Interventional · 20 enrolled · Duke UniversityNCT07017946updated 2026-04-13
Frequently asked questions
- How does Magnesium Citrate work?
- Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions; Stool Bulking Activity.
- What is Magnesium Citrate used for?
- According to FDA labeling, Magnesium Citrate carries indications including: Uses: • For relief of occasional constipation (irregularity).. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Magnesium Citrate?
- Magnesium Citrate is classified as Magnesium, Osmotically acting laxatives, Salt solutions, Acid-Base Activity, Electrolyte Activity, Enzyme Interactions, Stool Bulking Activity, Cellular Activity Alteration, Small Intestine Fluid/Electrolyte Absorption Alteration, Stimulation Large Intestine Fluid/Electrolyte Absorption.
- What are the brand names for Magnesium Citrate?
- Magnesium Citrate is marketed under brand names including Citroma.
magnesium-citrate is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.