pharmacopeia
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/api/v1/drug/manganese-chloride

Mechanism of action

Sourced from openFDA

Mechanism-of-action classes: Electrolyte Activity; Physiochemical Activity; Radiopharmaceutical Activity.

Indications

Sourced from openFDA
  • Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) is indicated for use in adult patients as a supplement to intravenous solutions given for TPN. Administration helps to maintain manganese serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

Contraindications

Sourced from openFDA
  • None known.contraindicated

Dosage & administration

Sourced from openFDA

Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) contains 0.1 mg manganese/mL and is administered intravenously only after dilution. The additive should be administered in a volume of fluid at least 100 mL. For the adult receiving TPN, the suggested additive dosage for manganese is 55 mcg/day (0.55 mL/day). Periodic monitoring of manganese plasma levels is suggested as a guideline for subsequent administration. (See WARNINGS .) Parenteral products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (See PRECAUTIONS .)

Warnings & precautions

Sourced from openFDA

Direct intramuscular or intravenous injection of Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) is contraindicated as the acidic pH of the solution (pH 2.0) may cause considerable tissue irritation. Neurologic Toxicity with Manganese Manganese accumulation in the basal ganglia has been reported in adult and pediatric patients on long‑term parenteral nutrition receiving manganese at higher than recommended dosages and in association with cholestatic liver disease. Brain MRI findings and clinical symptoms have also been observed in patients who received manganese at or below the recommended dosage and with normal blood manganese concentrations. Some adult patients with brain MRI findings reportedly experienced neuropsychiatric symptoms, including changes in mood or memory, seizures and/or parkinsonian‑like tremors, dysarthria, mask-face, and halting gait. Some pediatric patients experienced dystonic movements or seizures. Regression of symptoms and MRI findings have occurred over weeks to months following discontinuation of manganese in most patients but have not always completely resolved. Monitor patients receiving parenteral nutrition solutions containing manganese for neurologic signs and symptoms and routinely measure whole blood manganese concentrations and liver tests. In case of suspected manganese toxicity or new neuropsychiatric manifestations, temporarily discontinue manganese, check manganese whole blood concentrations, and consider brain MRI evaluation.

Adverse reactions

Sourced from openFDA

None known.

Use in specific populations

Sourced from openFDA

Pregnancy Animal reproduction studies have not been conducted with manganese chloride. It is also not known whether manganese chloride can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Manganese chloride should be given to a pregnant woman only if clearly indicated.

Overdosage

Sourced from openFDA

Acute manganese toxicity was reported in adult patients following infusion of manganese more than 10,000-fold the recommended dosage and after use of dialysis fluid contaminated with manganese. Signs and symptoms included skin flushing, acute pancreatitis, elevated whole blood manganese concentrations, and MRI evidence of brain accumulation of manganese. Chronic infusion and oral intake of manganese above recommended dosage have resulted in neuropsychiatric symptoms and MRI evidence of brain accumulation of manganese (see WARNINGS ).

Approval history

Sourced from openFDA
  • Jun 26, 1986NDANDA018962Hospira

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
271 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Fatigue3513%
  2. 2Headache2710.0%
  3. 3Nausea248.9%
  4. 4Dizziness217.7%
  5. 5Feeling Abnormal207.4%
  6. 6Pain197.0%
  7. 7Anxiety186.6%
  8. 8Diarrhoea186.6%
  9. 9Weight Decreased176.3%
  10. 10Asthenia165.9%
  11. 11Insomnia165.9%
  12. 12Drug Ineffective155.5%
  13. 13Dyspnoea155.5%
  14. 14Malaise134.8%
  15. 15Vomiting134.8%

Literature

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Recent PubMed references pinned to Manganese Chloride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 32 ClinicalTrials.gov registrations naming Manganese Chloride as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Frequently asked questions

How does Manganese Chloride work?
Mechanism-of-action classes: Electrolyte Activity; Physiochemical Activity; Radiopharmaceutical Activity.
What is Manganese Chloride used for?
According to FDA labeling, Manganese Chloride carries indications including: Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) is indicated for use in adult patients as a supplement to intravenous solutions given for TPN. Administration helps to maintain manganese serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Manganese Chloride?
Manganese Chloride is classified as Electrolyte Activity, Physiochemical Activity, Radiopharmaceutical Activity, Cellular Activity Alteration, Increased Cholesterol Synthesis, Increased Gluconeogenesis.
What are the contraindications for Manganese Chloride?
Manganese Chloride labeling lists contraindications including: None known.. Always consult the full prescribing information and a clinician.
Note. Data for manganese-chloride is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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