Miconazole

Mechanism-of-action classes: 14-alpha Demethylase Inhibitors; Ergosterol Synthesis Inhibitors.

• Uses for the treatment of most athlete's foot (tinea pedis), jock itch (tinea cruris), ringworm (tinea corporis) relieves most itching, scaling, cracking, burning, redness, soreness, irritation, discomfort and chafing associated with jock itchICD-10: B35.3

Directions Clean the affected area and dry thoroughly Apply a thin layer of powder over affected area twice daily (morning and night) or as directed by a doctor Supervise children in the use of this product For athlete's foot, pay special attention between spaces in toes; wear well-fitting, ventilated shoes, and change shoes and socks at least once daily For athlete's foot and ringworm, use daily for 4 weeks For jock itch, use daily for 2 weeks If condition persists longer, consult a doctor This product is not effective on the scalp or nails.

For external use only Do not use on children under 2 years of age unless directed by a doctor on scalp or nails When using this product avoid contact with the eyes Stop use and ask a doctor if irritation occurs there is no improvement within 4 weeks when used for the treatment of athlete's foot or ringworm there is no improvement within 2 weeks when used for the treatment of jock itch Keep out of reach of children If swallowed, get medical help or contact a Poison Control center right away.

• Jan 30, 1974NDANDA017450Medtech Products
• Nov 19, 1993ANDAANDA073508Actavis Pharma
• Apr 16, 1996NDANDA020670Medtech Products
• Mar 30, 1998NDANDA020827Medtech Products
• Feb 2, 2001NDANDA021261Medtech Products
• Jun 29, 2001NDANDA021308Medtech Products
• Feb 16, 2006NDANDA021026Mylan
• Apr 16, 2010NDANDA022404Galt Pharms

1. 1Vulvovaginal Burning Sensation1,67320%
2. 2Drug Ineffective1,14714%
3. 3Vulvovaginal Pain94911%
4. 4Vulvovaginal Pruritus5696.8%
5. 5Condition Aggravated5296.3%
6. 6Vaginal Haemorrhage4675.6%
7. 7Vulvovaginal Discomfort4225.0%
8. 8Vulvovaginal Swelling3043.6%
9. 9Drug Interaction3013.6%
10. 10Pain2723.2%
11. 11Off Label Use2523.0%
12. 12Diarrhoea2302.7%
13. 13Nausea2172.6%
14. 14Pruritus1992.4%
15. 15Dyspnoea1882.2%

Recent PubMed references pinned to Miconazole as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Medication Adherence and Patient-Reported Experience with Miconazole Mucoadhesive Buccal Tablets Compared with Oral Gel in the Treatment of Oral Candidiasis.
  Medical mycology journal · 2026 · Hiraga C, Sakai K, Minabe M, et al.
  PMID 42219354DOI 10.3314/mmj.25-00039
• New Miconazole Salts with Heterocyclic Carboxylic Acids with Improved Water Solubility and Enhanced Antifungal Activity.
  Molecules (Basel, Switzerland) · 2026 · Ben A, Felczak A, Gacki M, et al.
  PMID 42197241DOI 10.3390/molecules31101686
• In vitro evaluation of the antimicrobial activity of chlorhexidine alone or in combination with ketoconazole or miconazole against clinical isolates of Malassezia pachydermatis and multidrug-resistant Staphylococcus pseudintermedius.
  Microbiology (Reading, England) · 2026 · Goldman G, Santoro D
  PMID 42047687DOI 10.1099/mic.0.001701
• Cinnamon oil-driven lipid nanocarrier system for topical miconazole delivery: QbD-based development and characterization.
  Journal of pharmaceutical sciences · 2026 · Bukhari SI, Kharsa R, Otaibi MA, et al.
  PMID 41662955DOI 10.1016/j.xphs.2026.104195
• Therapeutic potential of intraperitoneal miconazole nitrate against Saprolegnia parasitica in Labeo rohita under feeding refusal conditions.
  Fish & shellfish immunology · 2026 · Singh M, Saha RK, Saha H, et al.
  PMID 41621551DOI 10.1016/j.fsi.2026.111167
• The Effect of Topical Ketoconazole and Topical Miconazole Nitrate in Modulating the Skin Microbiome and Mycobiome of Patients With Tinea Pedis.
  Mycoses · 2025 · Tan Y, Shao Y, Li T, et al.
  PMID 40964723DOI 10.1111/myc.70116
• Effect of a Spray Containing Occlusive Agents, Humectants and Physiological Lipids on Skin Hydration of Healthy Dogs When Applied After Bathing With a Chlorhexidine 2%/Miconazole 2% Shampoo.
  Veterinary dermatology · 2026 · Pseftogka A, Samuel Badulescu E, Chatzis MK, et al.
  PMID 40888083DOI 10.1111/vde.70025
• Long-term antifungal drug-delivery denture materials with plasma-initiated surface functionalization.
  Colloids and surfaces. B, Biointerfaces · 2025 · Wen J, Abdul-Azees PA, Matthew Lamb E, et al.
  PMID 40884851DOI 10.1016/j.colsurfb.2025.115077

The 10 most recently updated of 146 ClinicalTrials.gov registrations naming Miconazole as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Phase 2 EL219 Versus Liposomal Amphotericin B or Voriconazole for Early Antifungal Therapy
  Recruiting · Phase 2 · Interventional · 60 enrolled · Elion Therapeutics, Inc.
  NCT07215273updated 2026-06-09
• Vertebral Bone Marrow Clot for Spinal Surgery
  Active not recruiting · Interventional · 96 enrolled · Istituto Ortopedico Rizzoli
  NCT05947175updated 2026-05-27
• A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.
  Recruiting · Phase 3 · Interventional · 450 enrolled · Basilea Pharmaceutica
  NCT05421858updated 2026-05-20
• Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
  Recruiting · Phase 1 · Phase 2 · Interventional · 84 enrolled · AstraZeneca
  NCT07155226updated 2026-05-19
• Phase III Efficacy and Safety Study of Miconazole Oil for Otomycosis
  Completed · Phase 3 · Interventional · 112 enrolled · Hill Dermaceuticals, Inc.
  NCT05660382updated 2026-05-12
• Methods of T Cell Depletion Trial (MoTD)
  Recruiting · Phase 2 · Interventional · 400 enrolled · University of Birmingham
  NCT04888741updated 2026-05-05
• Improving the Care of Incontinence-Associated Dermatitis (IAD) Using a Beta-Glucan Cream as a Hydrating and Soothing Agent
  Not yet recruiting · Interventional · 60 enrolled · University of Alberta
  NCT07524439updated 2026-04-28
• Determining Elements of Anti-Fungal Immunity in BURN Patients
  Recruiting · Observational · 327 enrolled · Assistance Publique - Hôpitaux de Paris
  NCT06828458updated 2026-04-23
• Comparative Efficacy of Topical Clotrimazole Versus 2% Salicylic Acid in Otomycosis
  Completed · Interventional · 60 enrolled · Mayo Hospital Lahore
  NCT07535424updated 2026-04-17
• Geriatric Assessment & Genetic Profiling to Personalize Therapy in Older Adults With Acute Myeloid Leukemia
  Completed · Phase 2 · Interventional · 75 enrolled · University of Nebraska
  NCT03226418updated 2026-03-10

Frequently asked questions

How does Miconazole work?

Mechanism-of-action classes: 14-alpha Demethylase Inhibitors; Ergosterol Synthesis Inhibitors.

What is Miconazole used for?

According to FDA labeling, Miconazole carries indications including: Uses for the treatment of most athlete's foot (tinea pedis), jock itch (tinea cruris), ringworm (tinea corporis) relieves most itching, scaling, cracking, burning, redness, soreness, irritation, discomfort and chafing associated with jock itch. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Miconazole?

Miconazole is classified as Antiinfectives, Antiinfectives and antiseptics for local oral treatment, Imidazole and triazole derivatives, Imidazole derivatives, Azole Antifungal, 14-alpha Demethylase Inhibitors, Ergosterol Synthesis Inhibitors, Decreased Cell Membrane Integrity, Decreased Cell Wall Integrity.

What are the brand names for Miconazole?

Miconazole is marketed under brand names including Aloe Vesta Antifungal, Baza, Conazol Miconazole, Critic-Aid Clear, Cruex Prescription Strength, DermaFungal, Dermagran, Desenex.