Drug Interaction

325 drugs264,460 FAERS reportsMedDRA PT

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/api/v1/reaction/drug-interaction

Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.

DefinitionNLM MeSH D004347

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

Source: U.S. National Library of Medicine — MeSH (Drug Interactions)

Drugs reporting Drug Interaction (325)

Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.

1Octopamine1100%
2Amyl Nitrite1932%
3Fosamprenavir3728%
4Papaverine2323%
5Methylene Blue35721%
6Serotonin9020%
7Diethyltoluamide218%
8Pimozide7616%
9Rifapentine6513%
10Tranylcypromine14313%
11Atazanavir1,79212%
12Primaquine1012%
13Valproic Acid3,49111%
14Piperine111%
15Disulfiram12111%
16Tubocurarine110%
17Itraconazole1,14310.0%
18Lopinavir1,3349.9%
19Fluvoxamine2179.3%
20Rifabutin2538.9%
21Trimipramine1288.8%
22Clarithromycin2,9508.7%
23Ioflupane468.7%
24Air28.7%
25Galantamine2668.4%
26Voriconazole2,3407.9%
27Amisulpride4607.8%
28Hemp17.7%
29Acebutolol957.6%
30Benzyl Alcohol97.5%
31Verapamil3157.4%
32Nefazodone97.4%
33Rifampin1,0427.4%
34Raltegravir1,2077.4%
35Estazolam1387.2%
36Fluphenazine387.2%
37Propafenone3807.0%
38Flurazepam277.0%
39Perphenazine1436.9%
40Ibutilide26.9%
41Haloperidol1,8236.8%
42Efavirenz7576.8%
43Nitrogen76.7%
44Neostigmine1026.6%
45Benznidazole66.5%
46Podofilox76.4%
47Phenelzine1006.4%
48Etravirine2826.4%
49Pyrazinamide5866.4%
50Isoflurane1216.3%
51Manganese Sulfate56.3%
52Methamphetamine676.3%
53Trihexyphenidyl596.3%
54Clorazepate1186.3%
55Dipotassium1186.3%
56Fenoprofen36.3%
57Nitrous Oxide1336.2%
58Hetastarch106.2%
59Sevoflurane4806.1%
60Valproate1,2306.1%
61Lithium2,5346.1%
62Posaconazole9526.1%
63Ergotamine216.0%
64Repaglinide4225.8%
65Lithium Carbonate9975.8%
66Isoniazid9195.8%
67Desflurane975.8%
68Isradipine315.7%
69Droperidol895.7%
70Darunavir1,0685.6%
71Phenytoin2,2525.6%
72Succinylcholine2125.6%
73Oxazepam1,1625.6%
74Kaolin35.6%
75Cisatracurium1165.4%
76Ritonavir5,0625.4%
77Loxapine1995.4%
78Aminophylline1035.3%
79Letermovir1585.3%
80Hypromellose 220825.3%
81Calcium Hydroxide15.3%
82Carbamazepine3,4255.2%
83Nalmefene25.1%
84Pindolol405.1%
85Dipyridamole2015.1%
86Clomipramine2255.1%
87Atracurium355.0%
88Warfarin6,3535.0%
89Vecuronium765.0%
90Linezolid1,4204.9%
91Vadadustat124.9%
92Nitazoxanide164.8%
93Clobazam1,1474.8%
94Calcifediol1094.8%
95Ivabradine3144.7%
96Ethosuximide1154.7%
97Selegiline1634.7%
98Dronedarone4694.7%
99Chlorpromazine3244.6%
100Isoproterenol194.6%
101Perindopril2534.6%
102Benztropine3264.6%
103Methsuximide84.5%
104Lamivudine2,0764.4%
105Perampanel3234.4%
106Indapamide7624.4%
107Quetiapine8,2094.4%
108Fluconazole2,9864.3%
109Ethambutol1134.3%
110Trandolapril894.3%
111Vardenafil294.3%
112Colchicine1,1134.3%
113Propofol1,5454.3%
114Midazolam1,2384.3%
115Eplerenone5354.3%
116Fluvastatin3214.3%
117Aluminum Hydroxide3424.3%
118Phenobarbital6534.2%
119Amiodarone4584.2%
120Cocaine174.2%
121Terlipressin124.2%
122Isocarboxazid34.2%
123Pentazocine24.2%
124Tacrolimus6,3374.2%
125Cenobamate3344.1%
126Dexmedetomidine2564.1%
127Oxalate3,0814.1%
128Rocuronium4584.1%
129Nilutamide34.1%
130Felbamate714.1%
131Primidone4034.0%
132Etomidate874.0%
133Enalapril2,4454.0%
134Rufinamide1014.0%
135Mitotane694.0%
136Digoxin2,8094.0%
137Nicardipine1673.9%
138Aluminum3483.9%
139Nafcillin353.9%
140Amiloride353.9%
141Olanzapine4,1363.9%
142Fluoxetine4,9683.8%
143Oxacillin423.8%
144Imipramine273.8%
145Maraviroc863.8%
146Acarbose1433.8%
147Econazole343.8%
148Landiolol33.7%
149Stiripentol753.7%
150Fosphenytoin933.7%
151Mirtazapine3,2823.7%
152Tiagabine33.7%
153Flucytosine483.6%
154Methadone1,6453.6%
155Flumazenil303.6%
156Miconazole3013.6%
157Adenine23.6%
158Ramipril4,3223.6%
159Polystyrene Sulfonate563.6%
160Sodium Polystyrene Sulfonate563.6%
161Isosorbide Mononitrate7153.5%
162Diazepam4,1963.5%
163Dacomitinib263.5%
164Trifarotene63.5%
165Abacavir5523.5%
166Prazosin2463.4%
167Risperidone4,4903.4%
168Lamotrigine4,3663.4%
169Quinine3013.4%
170Donepezil1,2233.4%
171Glycopyrronium503.3%
172Adenosine533.3%
173Flecainide1693.3%
174Erythromycin6263.3%
175Ciprofloxacin3,1403.3%
176Oxcarbazepine1,0413.3%
177Sirolimus4233.3%
178Venlafaxine4,2363.3%
179Rasagiline3543.3%
180Theophylline3963.3%
181Zonisamide4703.2%
182Citalopram4,3663.2%
183Talc893.2%
184Cobicistat6603.2%
185Doxazosin1,1083.1%
186Remimazolam33.1%
187Dalteparin3233.1%
188Gemfibrozil4673.1%
189Doxepin3833.1%
190Sotalol5063.1%
191Silodosin1183.1%
192Anidulafungin483.1%
193Interleukin-10113.1%
194Interleukin-11113.1%
195Interleukin-3113.1%
196Interleukin-5113.1%
197Fosinopril1323.1%
198Cefuroxime4753.1%
199Lecithin33.1%
200Eptifibatide233.1%
201Dantrolene533.0%
202Captopril2923.0%
203Paroxetine2,7463.0%
204Flurbiprofen473.0%
205Ceftriaxone1,1343.0%
206Ticagrelor9473.0%
207Meropenem9383.0%
208Dopamine1133.0%
209Cabergoline1433.0%
210Sertraline6,4173.0%
211Torsemide9533.0%
212Terbinafine2573.0%
213Amoxapine143.0%
214Aripiprazole3,6502.9%
215Nimodipine322.9%
216Clonazepam4,6292.9%
217Sugammadex772.9%
218Triazolam2512.9%
219Tolcapone102.9%
220Sufentanil1882.9%
221Acetylcysteine2652.9%
222Diazoxide302.9%
223Isosorbide1,1322.9%
224Cetrorelix192.9%
225Dofetilide2982.9%
226Fondaparinux2292.9%
227Spironolactone3,9202.9%
228Simvastatin7,4482.8%
229Proguanil602.8%
230Mycophenolic Acid8792.8%
231Griseofulvin82.8%
232Miglitol262.8%
233Fentanyl3,1462.8%
234Chlorothiazide352.8%
235Escitalopram3,7662.8%
236Isavuconazonium932.7%
237Alfuzosin1532.7%
238Trazodone4152.7%
239Saxagliptin392.7%
240Cobaltous Chloride12.7%
241Vortioxetine4472.7%
242Lacosamide9702.7%
243Propranolol1,8652.7%
244Nifedipine1,2322.7%
245Gentamicin4122.7%
246Levofloxacin1,5652.7%
247Lonafarnib22.6%
248Exametazime12.6%
249Caspofungin1222.6%
250Levetiracetam3,4032.6%
251Clopidogrel5,4412.6%
252Meprobamate332.6%
253Tamsulosin5302.6%
254Dutasteride5662.6%
255Fenofibrate8942.6%
256Piperacillin8302.5%
257Furosemide9,9192.5%
258Disopyramide242.5%
259Clozapine3,0952.5%
260Tazobactam8432.5%
261Irbesartan1,2182.5%
262Cefotaxime1062.5%
263Daptomycin2202.5%
264Bromocriptine162.5%
265Mycophenolate3,2602.5%
266Mycophenolate Mofetil3,2602.5%
267Apixaban1,5832.5%
268Ranolazine2502.5%
269Lincomycin72.4%
270Ketoconazole4052.4%
271Nirmatrelvir1,2772.4%
272Nevirapine2132.4%
273Etrasimod372.4%
274Zidovudine4732.4%
275Nebivolol7812.4%
276Lactate1,7312.3%
277Cilostazol1422.3%
278Remifentanil542.3%
279Eslicarbazepine742.3%
280Cannabidiol5292.3%
281Cefazolin2732.3%
282Valganciclovir4242.3%
283Probenecid292.3%
284Amphotericin4632.3%
285Amphotericin B4632.3%
286Emtricitabine1,7732.3%
287Andexanet Alfa162.3%
288Memantine3152.3%
289Nalbuphine52.3%
290Tigecycline1352.3%
291Cariprazine1992.2%
292Edoxaban1402.2%
293Cilastatin912.2%
294Imipenem912.2%
295Allopurinol3,3762.2%
296Pyrantel12.2%
297Trypan Blue12.2%
298Brexpiprazole3492.2%
299Cefepime3372.1%
300Ofloxacin1492.1%
301Atovaquone2042.1%
302Dabigatran1,6242.1%
303Dabigatran Etexilate1,6242.1%
304Mebendazole162.1%
305Acetazolamide1202.0%
306Desmopressin662.0%
307Adagrasib202.0%
308Eliglustat302.0%
309Tedizolid152.0%
310Tecovirimat21.9%
311Leniolisib141.9%
312Apalutamide2031.8%
313Naldemedine281.8%
314Sebetralstat31.8%
315Mesylate3,0961.7%
316Remdesivir2221.7%
317Vinblastine321.7%
318Gallium71.7%
319Gozetotide71.7%
320Ethanol1301.6%
321Voxilaprevir161.5%
322Ledipasvir2691.4%
323Alprostadil491.4%
324Tapentadol3591.1%
325Bisoprolol5,707—

Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.

Literature

Recent PubMed references pinned to Drug Interactions as a MeSH major topic. About the reaction term itself — not about any specific drug.

Drug synergy prediction using heterogeneous stacking ensemble learning.
SAR and QSAR in environmental research · 2026 · Rani P, Dutta K, Kumar V, et al.
PMID 42169619DOI 10.1080/1062936X.2026.2666425
Flufenamic acid resensitizes MRSA to gentamicin through synergistic ion modulation.
The Journal of antimicrobial chemotherapy · 2026 · Ren X, Wu S, Rafique A, et al.
PMID 42130030DOI 10.1093/jac/dkag154
Effects of a High-Fat Meal on the Pharmacokinetics of Olverembatinib in Patients With Chronic Myeloid Leukemia.
Clinical and translational science · 2026 · Wang H, Yang Y, Chen Z, et al.
PMID 42105274DOI 10.1111/cts.70545
Learning drug synergy through environment-conditioned feature modulation.
Bioinformatics (Oxford, England) · 2026 · Jin S, Huang A, Meng Y, et al.
PMID 42085481DOI 10.1093/bioinformatics/btag256
Rethinking the role of synergy calculations in the next century of drug combination discovery.
Med (New York, N.Y.) · 2026 · Meyer CT, Dai Y, Pomeroy AE, et al.
PMID 42054999DOI 10.1016/j.medj.2026.101103
Evaluation of Relative Bioavailability and Food Effect of a Fixed-Dose Combination Tablet of Islatravir and Lenacapavir.
Journal of clinical pharmacology · 2026 · Niu J, Zhang H, Ling J, et al.
PMID 42053471DOI 10.1002/jcph.70193

What this is

Drug Interaction is a MedDRA Preferred Term reported on FAERS adverse-event submissions. Each entry below is one drug from the dataset whose FAERS reports mention this reaction.

MeSH descriptor

ID: D004347
Name: Drug Interactions
Synonyms: Drug Interaction, Interaction, Drug, Interactions, Drug
Tree: G07.690.773.968

Sits under

Pharmacological Phenomena

Full MeSH record

Try the API

cURLbash

curl https://pharmacopeia.dev/api/v1/reaction/drug-interaction

Source

Source: openFDA · FAERS
Coding: MedDRA Preferred Term
Aliases: —

open.fda.gov/data/faers/

Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.

Drug Interaction

DefinitionNLM MeSH D004347

Drugs reporting Drug Interaction (325)

Related reactions

Literature

Search pharmacopeia