Nonoxynol-9

Mechanism-of-action class: Surfactant Activity.

• Use for the prevention of pregnancy with condom or aloneICD-10: Z30.9

Directions For maximum protection against unwanted pregnancy, follow the enclosed directions exactly. Insert one applicatorful into the vagina prior to intercourse (see complete, illustrated directions on package insert). Each applicatorful is effective immediately and up to one hour after application. An additional applicatorful is required prior to each act of intercourse, regardless of time since last application.

For Vaginal Use Only Not for rectal (anal) use. Sexually Transmitted Disease (STDs) alert This product does not protect against HIV (AIDS) or other STDs and may increase the risk of getting HIV from an infected partner. Do not use if you or your sex partner has HIV/AIDS. If you do not know if you or your sex partner is infected, choose another form of birth control Stop use and ask a doctor if you or your partner get burning, itching, a rash, or other irritation of the vagina or penis. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

1. 1Dysuria429%
2. 2Burning Sensation214%
3. 3Dyspareunia214%
4. 4Vaginal Haemorrhage214%
5. 5Vulvovaginal Discomfort214%
6. 6Vulvovaginal Pain214%
7. 7Vulvovaginal Swelling214%
8. 8Chemical Burn Of Genitalia17.1%
9. 9Diarrhoea17.1%
10. 10Drug Ineffective17.1%
11. 11Dysmenorrhoea17.1%
12. 12Flushing17.1%
13. 13Hot Flush17.1%
14. 14Hypersensitivity17.1%
15. 15Medical Device Complication17.1%

Recent PubMed references pinned to Nonoxynol-9 as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Bayesian two-stage modeling of longitudinal and time-to-event data with an integrated fractional Brownian motion covariance structure.
  Biometrics · 2024 · Palipana A, Song S, Gupta N, et al.
  PMID 38483283DOI 10.1093/biomtc/ujae011
• The Association between Food Security Status and the Home Food Environment among a Sample of Rural South Carolina Residents.
  Nutrients · 2023 · Hossfeld C, Rennert L, Baxter SLK, et al.
  PMID 37764701DOI 10.3390/nu15183918
• Single-step SNPBLUP evaluation in six German beef cattle breeds.
  Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2023 · Adekale D, Alkhoder H, Liu Z, et al.
  PMID 37061869DOI 10.1111/jbg.12774
• A roadmap of craniofacial growth modification for children with sleep-disordered breathing: a multidisciplinary proposal.
  Sleep · 2023 · Yoon A, Gozal D, Kushida C, et al.
  PMID 37014012DOI 10.1093/sleep/zsad095
• Performance analysis of improved path loss models for millimeter-wave wireless network channels at 28 GHz and 38 GHz.
  PloS one · 2023 · Oladimeji TT, Kumar P, Elmezughi MK, et al.
  PMID 36943847DOI 10.1371/journal.pone.0283005
• Theoretical Examination Seeking Tangible Physical Meanings of Slopes and Intercepts of Plasma Concentration-Time Relationships in Minimal Physiologically Based Pharmacokinetic Models.
  The AAPS journal · 2023 · Jeong YS, Jusko WJ
  PMID 36702940DOI 10.1208/s12248-022-00779-x
• The relation between complement understanding and computational skills: A random intercept cross-lagged panel model.
  Developmental psychology · 2023 · Yip SE, Wong TT, Kwan KT, et al.
  PMID 36342436DOI 10.1037/dev0001481
• Effects of nonoxynol-9 (N-9) on sperm functions: systematic review and meta-analysis.
  Reproduction & fertility · 2022 · Xu M, Zhao M, Li RHW, et al.
  PMID 35350652DOI 10.1530/RAF-21-0024

The 10 most recently updated of 21 ClinicalTrials.gov registrations naming Nonoxynol-9 as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• AI-Assisted Acute Myeloid Leukemia Evaluation With the Leukemia End-to-End Analysis Platform (LEAP) Versus Clinician-Only Assessment
  Completed · Interventional · 10 enrolled · Harvard Medical School (HMS and HSDM)
  NCT07203885updated 2025-10-31
• The K-Map Study, Global Prevalence of KC
  Recruiting · Observational · 20,000 enrolled · University Hospital, Geneva
  NCT03115710updated 2025-08-11
• Effectiveness of SNAPPS in Family Medicine Residency Program
  Completed · Interventional · 36 enrolled · Hawler Medical University
  NCT06484010updated 2024-07-03
• Ovulation Double Check (Proov) Verification and Usability Testing
  Completed · Observational · 100 enrolled · MFB Fertility
  NCT03924440updated 2024-03-19
• The Contraceptive Efficacy and Safety of an Intravaginal Acetic Acid Thermoreversible Gel on Chinese Women.
  Not yet recruiting · Phase 2 · Interventional · 240 enrolled · National Research Institute for Family Planning, China
  NCT06203080updated 2024-01-12
• Study of Contraceptive Efficacy & Safety of Phexxi™ (Previously Known as Amphora) Gel Compared to Conceptrol Vaginal Gel
  Completed · Phase 3 · Interventional · 3,389 enrolled · Evofem Inc.
  NCT01306331updated 2022-07-12
• Enhanced Perioperative Care for the Prevention of Colorectal Anastomotic Leakage
  Unknown · Interventional · 1,600 enrolled · Amsterdam UMC, location VUmc
  NCT05250882updated 2022-02-22
• A Study of Nonoxynol-9 (N-9) and HIV Infection
  Completed · Phase 3 · Interventional · 4,400 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT00000926updated 2021-10-29
• A Study of the Effects of Advantage 24 on the Rectum
  Completed · Phase 1 · Interventional · 70 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT00000929updated 2021-10-29
• Investigating Wrong-Patient Computerized Physician Order Entry (CPOE) Errors
  Completed · Interventional · 4,028 enrolled · Montefiore Medical Center
  NCT01262053updated 2018-09-11

Frequently asked questions

How does Nonoxynol-9 work?

Mechanism-of-action class: Surfactant Activity.

What is Nonoxynol-9 used for?

According to FDA labeling, Nonoxynol-9 carries indications including: Use for the prevention of pregnancy with condom or alone. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Nonoxynol-9?

Nonoxynol-9 is classified as Surfactant Activity, Sperm Motility Alteration.

What are the brand names for Nonoxynol-9?

Nonoxynol-9 is marketed under brand names including Conceptrol, Gynol II, VCF Contraceptive.