pharmacopeia
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/api/v1/drug/oxymetazoline

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Adrenergic alpha-Agonists.

Indications

Sourced from openFDA
  • Uses temporarily relieves nasal congestion due to a cold, hay fever, or other upper respiratory allergies sinus congestion and pressure

Dosage & administration

Sourced from openFDA

Directions Remove protective cap. Before using for the first time, prime the pump by firmly depressing its rim several times. Hold container with thumb at base and nozzle between first and second fingers. Without tilting your head, insert nozzle into nostril. Fully depress rim with a firm, even stroke and inhale deeply. adults & children 6 yrs. & older (with adult supervision): 2 or 3 sprays in each nostril, not more often than every 10 to 12 hours. Do not exceed 2 doses in 24 hours. children 2 to under 6 yrs.: ask a doctor children under 2 yrs.: do not use

Warnings & precautions

Sourced from openFDA

For external use only; avoid contact with eyes. Do not use by mouth in nostrils on wounds or damaged skin with tight bandages Ask a doctor before use if you have heart disease high blood pressure thyroid disease diabetes trouble urinating due to enlarged prostate gland When using this product, do not do not exceed recommended dosage do not use this product for more than 3 days. Use only as directed. Frequent or prolonged use may cause nasal congestion to recur or worsen temporary discomfort such as burning, stinging, sneezing, or increased nasal discharge may occur use of this container by more than one person may spread infection Stop use and ask a doctor if symptoms persist. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Use in specific populations

Sourced from openFDA

If pregnant or breast-feeding, ask a health professional before use.

Approval history

Sourced from openFDA
  • Jan 18, 2017NDANDA208552Mayne Pharma
  • Jul 8, 2020NDANDA212520Rvl Pharms

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
7,600 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Drug Dependence1,13115%
  2. 2Drug Ineffective76110%
  3. 3Headache4015.3%
  4. 4Dyspnoea3264.3%
  5. 5Off Label Use3234.3%
  6. 6Vision Blurred2933.9%
  7. 7Anosmia2873.8%
  8. 8Nausea2533.3%
  9. 9Eye Irritation2463.2%
  10. 10Fatigue2453.2%
  11. 11Product Use Issue2383.1%
  12. 12Ocular Hyperaemia2283.0%
  13. 13Dizziness2242.9%
  14. 14Pain2172.9%
  15. 15Diarrhoea1942.6%

Literature

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Recent PubMed references pinned to Oxymetazoline as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 783 ClinicalTrials.gov registrations naming Oxymetazoline as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Frequently asked questions

How does Oxymetazoline work?
Mechanism-of-action class: Adrenergic alpha-Agonists.
What is Oxymetazoline used for?
According to FDA labeling, Oxymetazoline carries indications including: Uses temporarily relieves nasal congestion due to a cold, hay fever, or other upper respiratory allergies sinus congestion and pressure. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Oxymetazoline?
Oxymetazoline is classified as Other dermatologicals, Sympathomimetics, combinations excl. corticosteroids, Sympathomimetics, plain, Sympathomimetics used as decongestants, Vasoconstrictor, Adrenergic alpha-Agonists, Conjunctival Arterial Vasoconstriction, Decreased Nasal and Sinus Secretions, Increased Sympathetic Activity, Vasoconstriction.
What are the brand names for Oxymetazoline?
Oxymetazoline is marketed under brand names including Afrin, Allerest 12 Hour Nasal Spray, Dristan 12-Hour Nasal Spray, Duramist Plus, Four-Way, Kovanaze, Neo-Synephrine 12 Hour, Nostrilla.
Note. Data for oxymetazoline is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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