Drug Dependence
36 drugs276,051 FAERS reportsMedDRA PT
GET
/api/v1/reaction/drug-dependenceReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D019966
Disorders related to substance use or abuse.
Source: U.S. National Library of Medicine — MeSH (Substance-Related Disorders)
Drugs reporting Drug Dependence (36)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Hydrocodone39,92841%
- 2Hydromorphone35,09039%
- 3Oxycodone102,95427%
- 4Tubocurarine220%
- 5Propylhexedrine1119%
- 6Morphine33,88818%
- 7Oxymetazoline1,13115%
- 8Naloxone4,70713%
- 9Methadone5,93413%
- 10Carbachol1711%
- 11Narsoplimab17.1%
- 12Flumazenil576.9%
- 13Streptozocin146.3%
- 14Xylometazoline336.2%
- 15Acetaminophen39,1595.9%
- 16Tramadol2,1795.8%
- 17Fentanyl6,4105.7%
- 18Meperidine5105.6%
- 19Lutein25.4%
- 20Nalmefene25.1%
- 21Oxymorphone5835.0%
- 22Pantothenate25.0%
- 23Cocaine194.7%
- 24Carisoprodol7964.2%
- 25Pentazocine24.2%
- 26Serotonin183.9%
- 27Naltrexone1,3843.5%
- 28Amyl Nitrite23.3%
- 29Ephedrine213.3%
- 30Tapentadol1,0653.2%
- 31Meprobamate383.0%
- 32Nitrogen32.9%
- 33Ergotamine92.6%
- 34Levorphanol92.5%
- 35Nitrous Oxide482.2%
- 36Methamphetamine232.2%
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
- Drug Abuse19 shared · 0.26
- Dependence7 shared · 0.18
- Drug Withdrawal Syndrome8 shared · 0.17
- Drug Withdrawal Syndrome Neonatal6 shared · 0.17
- Overdose19 shared · 0.16
- Toxicity To Various Agents21 shared · 0.13
- Intentional Product Misuse7 shared · 0.11
- Cardiac Arrest12 shared · 0.10
- Emotional Distress9 shared · 0.09
- Respiratory Arrest4 shared · 0.09
Literature
Recent PubMed references pinned to Substance-Related Disorders as a MeSH major topic. About the reaction term itself — not about any specific drug.
- High-Deductible Health Plan Enrollment and Buprenorphine Dispensing.JAMA network open · 2026 · Chua KP, Bohnert AS, Conti RM, et al.PMID 42207512DOI 10.1001/jamanetworkopen.2026.15550
- Integrated Serum Pharmacochemistry, Network Pharmacology, and Experimental Validation to Explore the Active Components and Potential Mechanisms of Jujube Against Alcoholic Liver Disease.Biomedical chromatography : BMC · 2026 · Xu W, Han J, Weng Z, et al.PMID 42207218DOI 10.1002/bmc.70503
- Recreational Drug Use Amongst Children and Adolescents Presenting to Australian Emergency Departments With Acute Behavioural Disturbance: A Secondary Analysis of a Randomised Controlled Trial.Emergency medicine Australasia : EMA · 2026 · Bourke EM, Klein K, Selman CJ, et al.PMID 42206869DOI 10.1111/1742-6723.70279
- Barriers to addiction-related care during pregnancy in Nigeria: a scoping review and health system policy analysis.African journal of reproductive health · 2026 · Albert OM, Arthur A, Orukpe IO, et al.PMID 42202870DOI 10.29063/ajrh2026/v30i10.10
- Local availability of cannabis retail outlets on parents' cannabis use, acceptability, and perceived addictiveness: A longitudinal study in Washington State.PloS one · 2026 · Le VT, Bailey JA, Epstein M, et al.PMID 42201904DOI 10.1371/journal.pone.0348182
- P38γ drives aerobic glycolysis in liver sinusoidal endothelial cells and regulates alcoholic liver disease via the PFKFB3 signaling pathway.Molecular biology reports · 2026 · Zhang Q, Yang M, Zhang Y, et al.PMID 42201586DOI 10.1007/s11033-026-11853-4
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.