Pyridoxine

Mechanism-of-action class: Enzyme Interactions.

• PNV-DHA is a multivitamin/multimineral nutritional supplement indicated for use in the dietary management of patients with nutritional deficiencies or are in need of nutritional supplementation.

• This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.contraindicated

Before, during and/or after pregnancy, one softgel daily or as directed by a physician.

Ingestion of more than 3 grams of omega-3 fatty acids (such as DHA) per day has been shown to have potential antithrombotic effects, including an increased bleeding time and International Normalized Ratio (INR). Administration of omega-3 fatty acids should be avoided in patients taking anticoagulants and in those known to have an inherited or acquired predisposition to bleeding.

Allergic sensitization has been reported following both oral and parenteral administration of folic acid.

• Aug 14, 1972ANDAANDA080618Fresenius Kabi Usa
• Feb 21, 2001NDANDA021265Sandoz Canada Inc
• Apr 8, 2013NDANDA021876Duchesnay
• Aug 19, 2016ANDAANDA205811Actavis Labs Fl Inc
• Nov 7, 2016NDANDA209661Duchesnay
• Dec 6, 2017ANDAANDA208518Ph Health
• Aug 4, 2023ANDAANDA217000Bionpharma
• Apr 9, 2026ANDAANDA210273Apotex

1. 1Nausea54212%
2. 2Off Label Use48910%
3. 3Vomiting47610%
4. 4Pain4309.2%
5. 5Fatigue3738.0%
6. 6Diarrhoea3717.9%
7. 7Headache3537.5%
8. 8Drug Ineffective3427.3%
9. 9General Physical Health Deterioration3236.9%
10. 10Abdominal Pain3206.8%
11. 11Somnolence3146.7%
12. 12Condition Aggravated3106.6%
13. 13Constipation3056.5%
14. 14Abdominal Distension2896.2%
15. 15Dyspnoea2816.0%

Recent PubMed references pinned to Pyridoxine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Adolescent diagnosis of pyridoxine-dependent epilepsy.
  BMJ case reports · 2026 · Osman AA, Heva L, Kamal A, et al.
  PMID 42248600DOI 10.1136/bcr-2026-272010
• Potential of Antioxidant and Cardioprotective Activity of a New Pyridoxine and Fumaric Acid Derivative as an Inductor of Transcription Factor Nrf2.
  Bulletin of experimental biology and medicine · 2026 · Balakina AA, Podgurskaya AD, Mumyatova VA, et al.
  PMID 42043707DOI 10.1007/s10517-026-06667-0
• Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men.
  Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · Højfeldt G, Michaud J, Damgaard A, et al.
  PMID 41874466DOI 10.1002/advs.202518471
• Hydroxocobalamin, thiamine, and pyridoxine as an adjunct to standard treatment in chronic low back pain: a randomized clinical trial.
  Medicina clinica · 2026 · Reyes-Alvarez MT, Chávez Miñano V, Garro-Barrera B, et al.
  PMID 41604864DOI 10.1016/j.medcli.2025.107307
• In vitro biological properties of pyridoxine and ketorolac conjugates.
  Biomeditsinskaia khimiia · 2025 · Agafonova MN, Vasileva OS, Fafanova EM, et al.
  PMID 41556074DOI 10.18097/PBMCR1620
• Pyridoxine-Dependent Epilepsy in Newborn - A Rare and Challenging Diagnosis.
  Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) · 2025 · Pal M, Soltirovska-Šalamon A
  PMID 41363922DOI 10.2478/prilozi-2025-0027
• Development of novel lamellar nanoparticle formulation using arginine-β-branched hexyldecyl phosphate for dermal delivery of pyridoxine dicaprylate.
  Journal of pharmaceutical sciences · 2026 · Suzuki I, Uchino T, Hatta I, et al.
  PMID 41271037DOI 10.1016/j.xphs.2025.104074
• Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events in pediatric and adolescent epilepsy: a prospective, double-blind, randomized, placebo-controlled trial.
  Epilepsy & behavior : E&B · 2025 · Thananowan P, Simasathien T, Kitvorametha N, et al.
  PMID 40913882DOI 10.1016/j.yebeh.2025.110691

The 10 most recently updated of 378 ClinicalTrials.gov registrations naming Pyridoxine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis
  Recruiting · Phase 3 · Interventional · 150 enrolled · National University Hospital, Singapore
  NCT05473520updated 2026-06-09
• Composition for Treating Uterine Fibroid (SB-UF)
  Completed · Phase 4 · Interventional · 66 enrolled · Trieu, Nguyen Thi, M.D.
  NCT04762316updated 2026-06-08
• Immune-Mitochondrial Correction in Military Recruits
  Not yet recruiting · Interventional · 200 enrolled · MIPO Clinic
  NCT07622147updated 2026-06-02
• Adjunctive Doxycycline for Central Nervous System Tuberculosis
  Recruiting · Phase 2 · Interventional · 200 enrolled · National University Hospital, Singapore
  NCT06446245updated 2026-06-01
• Study of Limited Versus Continuous Isoniazid Tuberculosis Preventive Therapy in HIV-infected Persons in Botswana
  Completed · Phase 4 · Interventional · 1,995 enrolled · Centers for Disease Control and Prevention
  NCT00164281updated 2026-05-27
• Vitamin B Complex for Inferior Alveolar Nerve Paresthesia Recovery
  Not yet recruiting · Phase 4 · Interventional · 50 enrolled · University of Sao Paulo
  NCT07592897updated 2026-05-20
• Impact of a Novel Functional Snack on Perimenopausal Symptoms and Well-being
  Recruiting · Interventional · 20 enrolled · King's College London
  NCT07599930updated 2026-05-20
• The Danish Warfarin-Dialysis Study - Safety and Efficacy of Warfarin in Patients With Atrial Fibrillation on Dialysis
  Recruiting · Phase 4 · Interventional · 718 enrolled · Nicholas Carlson
  NCT03862859updated 2026-05-19
• Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood)
  Recruiting · Interventional · 84 enrolled · University of Ulster
  NCT07592975updated 2026-05-18
• Effects of Vitamin D, Epigallocatechin Gallate, Vitamin B6, and D-Chiro-inositol Combination on Uterine Fibroids
  Completed · Interventional · 108 enrolled · Universita di Verona
  NCT05409872updated 2026-05-05

Frequently asked questions

How does Pyridoxine work?

Mechanism-of-action class: Enzyme Interactions.

What is Pyridoxine used for?

According to FDA labeling, Pyridoxine carries indications including: PNV-DHA is a multivitamin/multimineral nutritional supplement indicated for use in the dietary management of patients with nutritional deficiencies or are in need of nutritional supplementation.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Pyridoxine?

Pyridoxine is classified as Other plain vitamin preparations, Vitamin B6 Analog, Enzyme Interactions, Cellular Activity Alteration.

What are the brand names for Pyridoxine?

Pyridoxine is marketed under brand names including Animi-3 with Vitamin D, Beelith, Bonjesta, Concept OB, Dialyvite 800, Dialyvite 800 with Iron, Dialyvite 800 with Zinc, Diclegis.

What are the contraindications for Pyridoxine?

Pyridoxine labeling lists contraindications including: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.. Always consult the full prescribing information and a clinician.