Riboflavin
Other ophthalmologicalsOther plain vitamin preparationsEnzyme InteractionsCellular Activity AlterationUS-FDASourced from openFDA
GET
/api/v1/drug/riboflavinMechanism of action
Sourced from openFDAMechanism-of-action class: Enzyme Interactions.
Indications
Sourced from openFDA- Dialyvite with Zinc is a prescription folic acid supplement with Zinc and additional nutrients indicated for use in improving the nutritional status of renal dialysis patients.
Contraindications
Sourced from openFDA- This product is contraindicated in patients with known hypersensitivity to any of the ingredients.contraindicated
Dosage & administration
Sourced from openFDATake one tablet per day or as directed by your physician, orally.
Adverse reactions
Sourced from openFDAAllergic sensitizations have been reported following oral administration of folic acid. Consult your physician immediately if adverse side effects occur.
Approval history
Sourced from openFDA- Feb 21, 2001NDANDA021265Sandoz Canada Inc
- Apr 15, 2016NDANDA203324Glaukos
- Oct 17, 2025NDANDA219910Glaukos
- Apr 9, 2026ANDAANDA210273Apotex
- Apr 9, 2026ANDAANDA210672Apotex
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
30,560 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Fatigue3,37011%
- 2Nausea2,2847.5%
- 3Diarrhoea2,2577.4%
- 4Headache2,0986.9%
- 5Pain1,8175.9%
- 6Drug Ineffective1,6675.5%
- 7Dizziness1,6645.4%
- 8Dyspnoea1,5375.0%
- 9Arthralgia1,4634.8%
- 10Asthenia1,4034.6%
- 11Off Label Use1,3114.3%
- 12Fall1,2864.2%
- 13Weight Decreased1,1043.6%
- 14Vomiting1,0923.6%
- 15Insomnia1,0843.5%
Literature
Recent PubMed references pinned to Riboflavin as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- [Sleep disorders and chronic cerebral ischemia].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026 · Putilina MVPMID 42268271DOI 10.17116/jnevro202612605242
- Synergistic effects of plant growth regulators, riboflavin, and iron nanoparticles on secondary metabolites in micropropagated Ceratonia siliqua L.Scientific reports · 2026 · Taha LS, Youssef NM, Ibrahim EA, et al.PMID 42243242DOI 10.1038/s41598-026-55883-1
- Engineered rabbit monoclonal antibodies and core-gap-shell gold nanoparticles for dual-modal lateral flow detection of vitamin B(2) in serum.Biosensors & bioelectronics · 2026 · Chen K, Sun T, Zhang Y, et al.PMID 42190455DOI 10.1016/j.bios.2026.118822
- Riboflavin-responsive hyperprolinemia type I with a PRODH p.Thr466Met variant: Clinical and fibroblast-based evidence.Molecular genetics and metabolism · 2026 · Kido J, Sugawara K, Egashira I, et al.PMID 42150437DOI 10.1016/j.ymgme.2026.110143
- Characterization of pericardium collagen stiffening after riboflavin/UV- and low energy electron irradiation by IR spectroscopic imaging.International journal of biological macromolecules · 2026 · Dittfeld C, Welzel C, Jannasch A, et al.PMID 42142781DOI 10.1016/j.ijbiomac.2026.152574
- Clinical Outcomes and Safety of Customized Corneal Cross-linking for Keratoconus: A Systematic Review and Meta-analysis.Journal of refractive surgery (Thorofare, N.J. : 1995) · 2026 · Hsu JH, Tsai TH, Lin TW, et al.PMID 42113928DOI 10.3928/1081597X-20260216-01
- Fabrication and Surgical Application of Enriched Photo-crosslinked Gelatin-Riboflavin Hydrogels for Corneal Wound Repair in Rabbits.Journal of visualized experiments : JoVE · 2026 · Romo-Valera C, Etxebarria J, Rodriguez-Astigarraga M, et al.PMID 42113687DOI 10.3791/70579
- Heterologous expression as a tool to increase GABA and riboflavin production in fermented vegetable beverages.International journal of food microbiology · 2026 · Langa S, Flores JA, Peirotén Á, et al.PMID 42097055DOI 10.1016/j.ijfoodmicro.2026.111820
Clinical trials
The 10 most recently updated of 347 ClinicalTrials.gov registrations naming Riboflavin as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for KeratoconusRecruiting · Phase 4 · Interventional · 15 enrolled · Glaukos CorporationNCT07629557updated 2026-06-05
- Immune-Mitochondrial Correction in Military RecruitsNot yet recruiting · Interventional · 200 enrolled · MIPO ClinicNCT07622147updated 2026-06-02
- The Effect of Vitamin D on in Vitro Fertilization OutcomeCompleted · Observational · 688 enrolled · The First Affiliated Hospital of Zhengzhou UniversityNCT02361827updated 2026-05-27
- Vitamin B Complex for Inferior Alveolar Nerve Paresthesia RecoveryNot yet recruiting · Phase 4 · Interventional · 50 enrolled · University of Sao PauloNCT07592897updated 2026-05-20
- Impact of a Novel Functional Snack on Perimenopausal Symptoms and Well-beingRecruiting · Interventional · 20 enrolled · King's College LondonNCT07599930updated 2026-05-20
- Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood)Recruiting · Interventional · 84 enrolled · University of UlsterNCT07592975updated 2026-05-18
- Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical TrialActive not recruiting · Phase 3 · Interventional · 36 enrolled · Sahlgrenska University HospitalNCT01604135updated 2026-05-11
- Effectiveness of Riboflavin-Moxifloxacin Amniotic Membrane as an Adjuvant for PACK-CXL in Moderate to Severe Infectious KeratitisCompleted · Phase 2 · Interventional · 32 enrolled · Gadjah Mada UniversityNCT07559149updated 2026-04-30
- Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal MeltingRecruiting · Interventional · 40 enrolled · Centre hospitalier de l'Université de Montréal (CHUM)NCT03041883updated 2026-04-28
- Efficacy of Nutritional Supplements on Children With Autism Spectrum DisorderCompleted · Phase 2 · Interventional · 88 enrolled · Fei LiNCT06911905updated 2026-04-23
Frequently asked questions
- How does Riboflavin work?
- Mechanism-of-action class: Enzyme Interactions.
- What is Riboflavin used for?
- According to FDA labeling, Riboflavin carries indications including: Dialyvite with Zinc is a prescription folic acid supplement with Zinc and additional nutrients indicated for use in improving the nutritional status of renal dialysis patients.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Riboflavin?
- Riboflavin is classified as Other ophthalmologicals, Other plain vitamin preparations, Enzyme Interactions, Cellular Activity Alteration.
- What are the brand names for Riboflavin?
- Riboflavin is marketed under brand names including Concept OB, Dialyvite 800, Dialyvite 800 with Iron, Dialyvite 800 with Zinc, Eldertonic, Ellis Tonic, Hemocyte Plus, Infuvite.
- What are the contraindications for Riboflavin?
- Riboflavin labeling lists contraindications including: This product is contraindicated in patients with known hypersensitivity to any of the ingredients.. Always consult the full prescribing information and a clinician.
Note. Data for
riboflavin is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.