Salicylic Acid
GET
/api/v1/drug/salicylic-acidMechanism of action
Sourced from openFDAMechanism-of-action class: Unknown Cellular or Molecular Interaction.
Indications
Sourced from openFDA- Use for the treatment of acneICD-10: L70.0
Dosage & administration
Sourced from openFDADirections wet face, apply to hand, massage face gently. Rinse well. Use up to twice daily. avoid contact with eyes. If contact occurs, flush thoroughly with water.
Warnings & precautions
Sourced from openFDAFor external use only
Adverse reactions
Sourced from openFDAADVERSE REACTION Information: 1-888-287-1915 or Walmart.com/help DISTRIBUTED BY: Walmart Inc., Bentonville, AR 72716 PLASTIC TUBE Do Not Recycle how2recycle.info Made in the USA with domestic and imported ingredients. Factory Certified
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
52,498 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Drug Ineffective13,78426%
- 2Dry Skin12,76524%
- 3Erythema12,31723%
- 4Acne11,76122%
- 5Skin Burning Sensation11,55522%
- 6Skin Irritation7,72915%
- 7Skin Exfoliation5,75711%
- 8Inappropriate Schedule Of Product Administration4,8089.2%
- 9Rash4,7549.1%
- 10Overdose3,7777.2%
- 11Pain Of Skin3,4986.7%
- 12Pruritus3,4626.6%
- 13Hypersensitivity2,9805.7%
- 14Condition Aggravated1,6573.2%
- 15Underdose1,4812.8%
Literature
Recent PubMed references pinned to Salicylic Acid as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- The Protective Role of Salicylic Acid-Conjugated Chitosan Nanoparticles Against Cryodamage in Buffalo Semen.Reproduction in domestic animals = Zuchthygiene · 2026 · Khalil WA, Ismail AA, Hassan MAE, et al.PMID 42257507DOI 10.1111/rda.70247
- A Novel Retinoid and Salicylic Acid Topical Treatment for Moderate-Severe Acne.Journal of drugs in dermatology : JDD · 2026 · Hornby SB, Ly YH, Obagi ZA, et al.PMID 42235053DOI 10.36849/JDD.9390
- Randomized Controlled Study of Bacteriophages in Acne Reveals Efficacy and Novel Mechanism for Promoting Long-Term Skin Health.Journal of drugs in dermatology : JDD · 2026 · Prooyen NV, Cho M, Jiang L, et al.PMID 42235049DOI 10.36849/JDD.9346
- From signalling to resistance; delineating the multifaceted role of salicylic acid as the key modulator of biotic stress tolerance.Functional plant biology : FPB · 2026 · Bhar A, Gupta S, Banerjee DB, et al.PMID 42225082DOI 10.1071/FP25406
- Excess nitric oxide alters cellular pH to restrict salicylic acid movement and systemic immunity.Science advances · 2026 · Xia F, Liu H, Yu K, et al.PMID 42213848DOI 10.1126/sciadv.adz4776
- Massilia strains facilitate root growth and reshape root microbiota through diverse salicylic acid hydrolysis pathways.The ISME journal · 2026 · Han Q, Zhu G, Li C, et al.PMID 42189906DOI 10.1093/ismejo/wrag082
- Innovative silver-salicylic acid nanoparticle coatings based on CMC and chitosan for mango (Mangifera indica L. cv. "Fajri Klan") fruit preservation.Scientific reports · 2026 · Hmmam I, Abdallatif A, Mamdouh BM, et al.PMID 42156462DOI 10.1038/s41598-026-52586-5
- Drought stress induces salicylic acid accumulation, altering monoterpene profile and suppressing resin duct formation in Engelmann spruce.PloS one · 2026 · Davis TS, Khedive E, Hill E, et al.PMID 42133747DOI 10.1371/journal.pone.0349209
Clinical trials
The 10 most recently updated of 212 ClinicalTrials.gov registrations naming Salicylic Acid as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Chronic Hypertension and Acetyl Salicylic Acid in PregnancyRecruiting · Phase 3 · Interventional · 500 enrolled · Centre Hospitalier Intercommunal CreteilNCT04356326updated 2026-06-12
- Botulinum Toxin-A for Bruxism Using Digital Occlusal AnalysisNot yet recruiting · Early phase 1 · Interventional · 36 enrolled · Bilecik Seyh Edebali UniversitesiNCT07640035updated 2026-06-10
- A Comparative Clinical Assessment of Adjunctive Hyaluronic Acid With 3D Printed Versus Milled CAD CAM Provisional Dental Restorations on Active Periodontal Status and Surface Roughness and BiocompatibilityNot yet recruiting · Interventional · 60 enrolled · Cairo UniversityNCT07625839updated 2026-06-04
- Autonomic Control of the Circulation and VDRRecruiting · Early phase 1 · Interventional · 18 enrolled · Milton S. Hershey Medical CenterNCT03513770updated 2026-06-02
- ASPIRED-XT: ASPirin Intervention for the REDuction of Colorectal Cancer Risk -EXTensionActive not recruiting · Early phase 1 · Interventional · 161 enrolled · Massachusetts General HospitalNCT05056896updated 2026-05-15
- Can Flowable Bulk Fill Composites be Used in Proximal Area of Class II RestorationsCompleted · Interventional · 38 enrolled · Universidade Federal FluminenseNCT06183320updated 2026-05-15
- Non-Randomized Trial of Bruxism-Related TMD TreatmentsCompleted · Phase 4 · Interventional · 60 enrolled · Recep Tayyip Erdogan UniversityNCT07586072updated 2026-05-14
- Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by SurgeryCompleted · Phase 2 · Phase 3 · Interventional · 612 enrolled · NRG OncologyNCT03070886updated 2026-05-07
- Fenofibrate in Ulcerative ColitisCompleted · Phase 2 · Phase 3 · Interventional · 60 enrolled · Tanta UniversityNCT05753267updated 2026-05-04
- Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance TrialActive not recruiting · Phase 3 · Interventional · 2,050 enrolled · NRG OncologyNCT05050084updated 2026-05-04
Frequently asked questions
- How does Salicylic Acid work?
- Mechanism-of-action class: Unknown Cellular or Molecular Interaction.
- What is Salicylic Acid used for?
- According to FDA labeling, Salicylic Acid carries indications including: Use for the treatment of acne. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Salicylic Acid?
- Salicylic Acid is classified as Antiinflammatory agents, non-steroids, Other antifungals for topical use, Unknown Cellular or Molecular Interaction, Increased Skin Keratinization.
- What are the brand names for Salicylic Acid?
- Salicylic Acid is marketed under brand names including AcneWorx, Acneclir, Acnevir, Ala Seb T, Azo Urinary Tract Defense, Bensal, Broda Acne Spa, Clear Proof Acne Medication.
Note. Data for
salicylic-acid is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.