Simethicone

Mechanism-of-action class: Surfactant Activity.

• Uses For the relief of pressure and bloating commonly referred to as gas

Directions adults: swallow with water 1 or 2 softgels as needed after meals and at bedtime do not exceed 2 softgels in 24 hours except under the advice and supervision of a physician

If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.

• Sep 6, 2006ANDAANDA077500Sun Pharm Inds Ltd
• Sep 5, 2018ANDAANDA209837Perrigo R And D
• Dec 14, 2020ANDAANDA211059Aurobindo Pharma Ltd
• May 27, 2021ANDAANDA214541Guardian Drug
• Jun 17, 2021ANDAANDA211438Hetero Labs Ltd V
• Sep 10, 2021ANDAANDA213484Bionpharma
• Aug 29, 2022ANDAANDA215981Granules

1. 1Chronic Kidney Disease1,15714%
2. 2Nausea7018.7%
3. 3Diarrhoea6498.0%
4. 4Acute Kidney Injury6317.8%
5. 5Fatigue6157.6%
6. 6Renal Failure5827.2%
7. 7Pain4095.1%
8. 8Gastrooesophageal Reflux Disease4025.0%
9. 9Vomiting3944.9%
10. 10Dyspnoea3934.9%
11. 11Headache3904.8%
12. 12Drug Ineffective3664.5%
13. 13Constipation3524.4%
14. 14End Stage Renal Disease3384.2%
15. 15Asthenia3294.1%

Recent PubMed references pinned to Simethicone as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Efficacy and Safety of Pre-Endoscopy Regimens for Mucosal Visualization During Sedated Esophagogastro-duodenoscopy: A Randomized Controlled Trial.
  Acta medica Indonesiana · 2026 · Yusuf F, Abubakar A, Maghfirah D, et al.
  PMID 41978298
• Impact of Timing of Premedication on Mucosal Visibility During Endoscopy: A Randomized Controlled Trial.
  Journal of gastroenterology and hepatology · 2026 · Nabi Z, Dasireddy PS, Sayyed M, et al.
  PMID 41960652DOI 10.1111/jgh.70392
• Pre-endoscopy drink of small doses of simethicone and pronase solution improves visualization in upper gastrointestinal endoscopy: Randomised double-blind experiment.
  Medicine · 2025 · Li Y, Jiang J, Sheng J, et al.
  PMID 41327659DOI 10.1097/MD.0000000000046271
• Simethicone dosages with minimal normal saline solution volume to enhance mucosal visualization in upper endoscopy: a multicenter, randomized, double-blind, placebo-controlled trial.
  Scientific reports · 2025 · Saeung S, Morasert T, Wannawong P, et al.
  PMID 41318875DOI 10.1038/s41598-025-30192-1
• Efficacy and Safety of Bowel Cleansing with Mini S-Oral Sulfate Tablet versus the Conventional Oral Sulfate Tablet: A Prospective, Randomized, Investigator-Blinded, Multicenter, Noninferior, Phase 3 Trial.
  Gut and liver · 2026 · Park SK, Jeon SR, Yang DH, et al.
  PMID 41306094DOI 10.5009/gnl250291
• Efficacy of a mixture of simethicone and tyndallized bacillus coagulans in infant colic: a pilot study on behalf of Italian Society of Pediatrics (SIP).
  Italian journal of pediatrics · 2025 · Saviano M, Russo M, Buono P, et al.
  PMID 41225617DOI 10.1186/s13052-025-02140-2
• Comparative efficacy of 200 mg versus 1200 mg of simethicone with 3 L polyethylene glycol electrolyte solution for afternoon colonoscopy: a randomized controlled trial.
  BMC gastroenterology · 2025 · Cai X, Xue P, Li Y, et al.
  PMID 41073931DOI 10.1186/s12876-025-04215-0
• The efficacy and safety of simethicone for gastrointestinal preparation prior to pediatric endoscopy: a systematic review and meta-analysis.
  European journal of pediatrics · 2025 · Li S, Geng T, Li Z, et al.
  PMID 40906278DOI 10.1007/s00431-025-06438-5

The 10 most recently updated of 111 ClinicalTrials.gov registrations naming Simethicone as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Famotidine and Antacids for Treatment of Dyspepsia
  Recruiting · Phase 4 · Interventional · 80 enrolled · Stony Brook University
  NCT06241183updated 2026-06-02
• Effects of Pre-procedure and Intra-procedure Simethicone and Dicyclomine Administration in Improving Quality of Endoscopic Reterograde Cholangipancreaticography (ERCP)
  Completed · Phase 4 · Interventional · 90 enrolled · CMH Lahore Medical College and Institute of Dentistry
  NCT07461389updated 2026-04-13
• Effect of Intraluminal Administration of Menthol Solution During Colonoscopy on Colonic Spasm and Adenoma Detection Rate
  Not yet recruiting · Interventional · 440 enrolled · The First Affiliated Hospital of Zhengzhou University
  NCT07501962updated 2026-03-30
• Effect of a Novel Colonoscopic Lavage Solution on Colonoscopy Quality
  Not yet recruiting · Interventional · 498 enrolled · The First Affiliated Hospital of Zhengzhou University
  NCT07501975updated 2026-03-30
• Robot-controlled Magnet-Assisted Capsule Endoscopy
  Completed · Interventional · 15 enrolled · Sheffield Children's NHS Foundation Trust
  NCT06030518updated 2026-03-10
• 4-L Split-dose Polyethylene Glycol and Bisacodyl and Docusate Sodium Regimen Versus 2-L Split-dose Polyethylene Glycol Plus Oral Simethicone Regimen for Bowel Preparation Before Colonoscopy
  Recruiting · Interventional · 450 enrolled · Tanta University
  NCT07328880updated 2026-01-09
• Effect of Simethicone on Helicobacter Pylori Detection in Routine Endoscopy
  Not yet recruiting · Interventional · 100 enrolled · Asian Institute of Gastroenterology, India
  NCT07293234updated 2026-01-02
• Effect of Non-invasive Neuromodulation on the Quality of Intestinal Cleansing
  Not yet recruiting · Interventional · 270 enrolled · Shanghai East Hospital
  NCT07290816updated 2025-12-18
• Hot Water Foot Bath for Pain and Gas Relief After Laparoscopic Cholecystectomy
  Not yet recruiting · Interventional · 62 enrolled · Cansu Mert
  NCT07126223updated 2025-12-05
• Double-blind, Randomized, Placebo-controlled Trial of Ganaxolone in CDKL5 Deficiency Patients 6 Months to Less Than 2 Years Old
  Not yet recruiting · Phase 3 · Interventional · 20 enrolled · Immedica Pharma AB
  NCT05249556updated 2025-11-28

Frequently asked questions

How does Simethicone work?

Mechanism-of-action class: Surfactant Activity.

What is Simethicone used for?

According to FDA labeling, Simethicone carries indications including: Uses For the relief of pressure and bloating commonly referred to as gas. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Simethicone?

Simethicone is classified as Surfactant Activity, Digestive Alteration.

What are the brand names for Simethicone?

Simethicone is marketed under brand names including Almacone, Bicarsim, Comfort Gel, E-Z-Gas II, Gas Aide, Gas-X, Gas-X Total Relief, Gas-X with Maalox.