Sulfacetamide

Mechanism-of-action class: Para-Aminobenzoic Acid Inhibitors.

• This product is intended for topical application in the following scaling dermatoses: seborrheic dermatitis and seborrhea sicca (dandruff). It also is indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides.

• This product is contraindicated in persons with known or suspected hypersensitivity to any of the ingredients of the product. This product is not to be used by patients with kidney disease.contraindicated

Seborrheic dermatitis including seborrhea sicca - Shake well before using. Apply to affected areas twice daily (morning and evening), or as directed by your physician. Avoid contact with eyes or mucous membranes. Repeat application as described for eight to ten days. As the condition subsides, the interval between applications may be lengthened. Applications once or twice weekly or every other week may prevent recurrence. Should the condition recur after stopping therapy, the application of this product should be reinitiated as at the beginning of treatment. Secondary cutaneous bacterial infections - Shake well before using. Apply to affected areas twice daily for eight to ten days.

Sulfonamides are known to cause Stevens-Johnson syndrome in hypersensitive individuals. Stevens-Johnson syndrome also has been reported following the use of sodium sulfacetamide topically. Cases of drug-induced systemic lupus erythematosus from topical sulfacetamide also have been reported. In one of these cases, there was a fatal outcome. KEEP OUT OF THE REACH OF CHILDREN.

Reports of irritation and hypersensitivity to sodium sulfacetamide are uncommon. The following adverse reactions, reported after administration of sterile ophthalmic sodium sulfacetamide, are noteworthy: instances of Stevens-Johnson syndrome and instances of local hypersensitivity which progressed to a syndrome resembling systemic lupus erythematosus; in one case a fatal outcome was reported (see WARNINGS).

The oral LD 50 of sulfacetamide in mice is 16.5 g/kg. In the event of overdosage, emergency treatment should be started immediately. Manifestations: Overdosage may cause nausea and vomiting. Large oral overdosage may cause hematuria, crystalluria and renal shutdown due to the precipitation of sulfa crystals in the renal tubules and the urinary tract. For treatment, contact your local Poison Control Center or your doctor.

• Dec 28, 1994ANDAANDA040066Bausch And Lomb
• Dec 29, 1995ANDAANDA074449Bausch And Lomb
• Dec 23, 1996NDANDA019931Bausch
• Mar 23, 2009ANDAANDA078649Padagis Us

1. 1Drug Ineffective679.3%
2. 2Drug Hypersensitivity669.1%
3. 3Nausea466.4%
4. 4Pain435.9%
5. 5Headache375.1%
6. 6Off Label Use375.1%
7. 7Dyspnoea365.0%
8. 8Rash354.8%
9. 9Fatigue304.1%
10. 10Weight Decreased263.6%
11. 11Erythema253.5%
12. 12Dizziness233.2%
13. 13Pruritus233.2%
14. 14Vomiting233.2%
15. 15Back Pain223.0%

Recent PubMed references pinned to Sulfacetamide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Transcriptomics unveiled metabolic perturbations in Desmodesmus quadricauda by sulfacetamide: Key functional genes involved in the tolerance and biodegradation process.
  The Science of the total environment · 2022 · Xiong JQ, Qi X, Qin JY, et al.
  PMID 35276146DOI 10.1016/j.scitotenv.2022.154436
• Spectroscopic investigation of π-acceptors in the determination and photoinduced degradation of Sulfacetamide.
  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2020 · Shehab OR, Soliman FA, Abdel-Ghani NT, et al.
  PMID 31791911DOI 10.1016/j.saa.2019.117821
• Solubility advantage of sulfanilamide and sulfacetamide in natural deep eutectic systems: experimental and theoretical investigations.
  Drug development and industrial pharmacy · 2019 · Jeliński T, Przybyłek M, Cysewski P, et al.
  PMID 30883240DOI 10.1080/03639045.2019.1597104
• Reply re: "The Bleph and the Brain: The Effect of Upper Eyelid Surgery on Chronic Headaches".
  Ophthalmic plastic and reconstructive surgery · 2018 · Mokhtarzadeh A, McClelland C, Lee MS, et al.
  PMID 29517598DOI 10.1097/IOP.0000000000001066
• Re: "The Bleph and the Brain: The Effect of Upper Eyelid Surgery on Chronic Headaches".
  Ophthalmic plastic and reconstructive surgery · 2018 · Mandal P, Ghosh Y
  PMID 29517597DOI 10.1097/IOP.0000000000001020
• Validated Chromatographic Methods for the Simultaneous Determination of Sulfacetamide Sodium and Prednisolone Acetate in their Ophthalmic Suspension.
  Journal of chromatographic science · 2017 · El-Ragehy NA, Hegazy MA, AbdElHamid G, et al.
  PMID 28985412DOI 10.1093/chromsci/bmx064
• Transport of sulfacetamide and levofloxacin in granular porous media under various conditions: Experimental observations and model simulations.
  The Science of the total environment · 2016 · Dong S, Gao B, Sun Y, et al.
  PMID 27692941DOI 10.1016/j.scitotenv.2016.09.164
• Synthesis, characterization, theoretical prediction of activities and evaluation of biological activities of some sulfacetamide based hydroxytriazenes.
  Bioorganic & medicinal chemistry letters · 2016 · Agarwal S, Baroliya PK, Bhargava A, et al.
  PMID 27136718DOI 10.1016/j.bmcl.2016.04.051

The 2 most recently updated of 2 ClinicalTrials.gov registrations naming Sulfacetamide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Patients Response to Early Switch To Oral:Osteomyelitis Study
  Terminated · Early phase 1 · Interventional · 11 enrolled · Julio Ramirez
  NCT02099240updated 2021-04-06
• Intraductal Meibomian Gland Probing Trial
  Completed · Phase 4 · Interventional · 45 enrolled · Joseph B. Ciolino, MD
  NCT02256969updated 2017-06-19

CPIC-curated drug–gene pairs for Sulfacetamide. Levels describe the strength of curated evidence and guideline status — never a recommendation to test or to adjust therapy.

• G6PDCPIC C
  G6PD

Frequently asked questions

How does Sulfacetamide work?

Mechanism-of-action class: Para-Aminobenzoic Acid Inhibitors.

What is Sulfacetamide used for?

According to FDA labeling, Sulfacetamide carries indications including: This product is intended for topical application in the following scaling dermatoses: seborrheic dermatitis and seborrhea sicca (dandruff). It also is indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Sulfacetamide?

Sulfacetamide is classified as Antiinfectives for treatment of acne, Sulfonamides, Sulfonamide Antibacterial, Para-Aminobenzoic Acid Inhibitors, Cellular Growth Phase Arrest, Cellular Synthetic Activity Alteration, Decreased Folic Acid Modification.

What are the brand names for Sulfacetamide?

Sulfacetamide is marketed under brand names including Avar, BP 10-Wash, BP Cleansing Wash, Bleph-10, Blephamide, Carmol Scalp, Clenia, Klaron.

What are the contraindications for Sulfacetamide?

Sulfacetamide labeling lists contraindications including: This product is contraindicated in persons with known or suspected hypersensitivity to any of the ingredients of the product. This product is not to be used by patients with kidney disease.. Always consult the full prescribing information and a clinician.